{"title":"Shop All","description":"","products":[{"product_id":"calm-mind-60ct","title":"Calm Mind 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports emotional well-being\u003cbr\u003e* Supports a positive mood and emotional outlook\u003cbr\u003e* Promotes a calm state of mind\u003cbr\u003e* Supports sleep with continued use\u003cbr\u003e* Clinically studied saffron (affron®)\u003cbr\u003e* Clinically studied curcumin (Theracurmin®) with 27x enhanced bioavailability\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Patients seeking support for mood and emotional well-being\u003cbr\u003e* Patients experiencing occasional stress and\/or sleeplessness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eCalm Mind combines two clinically studied botanical extracts, saffron (affron®) and curcumin (Theracurmin®), to support a positive mood, a calm state of mind and emotional well being. In a double-blind trial involving 128 adults self-reporting low mood, saffron (affron®, 28 mg\/day) resulted in a significant decrease in negative mood and symptoms related to stress after 4 weeks compared to placebo.1 Other studies indicate that saffron also supports sleep with continued use.2-4 The regulation of mood and emotional state is influenced by the immune system, and emerging research points to an impactful role of immune mediators known as cytokines.5 Lower plasma levels of certain cytokines, such as IL-6 and TNF-α, are associated with positive mood and emotional well-being.5, 6 In preclinical models, curcumin moderates the production of the cytokines IL-1β, IL-6, and TNF-α5, 6 and moderates pro-inflammatory cytokine pathways in the brain.7, 8 However, the low oral bioavailability of curcumin may limit its ability to support brain function. Theracurmin® is 27 times more bioavailable than standard curcumin.9 In a study of 40 adults (51--84 years of age) Theracurmin® containing 90 mg curcumin twice daily for 18 months significantly improved short-term, verbal and visual memory and attention.10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kell G, et al. *Complement Ther Med*. 2017 Aug;33:58-64.\u003cbr\u003e2. Nishide A, et al. *Jpn Pharmacol Ther*. 2018;46:8.\u003cbr\u003e3. Lopresti AL, et al. *Sleep Med*. 2021 Oct;86:7-18.\u003cbr\u003e4. Lopresti AL et al. *J Clin Sleep Med*. 2020 Jun 15;16(6):937-947.\u003cbr\u003e5. Hassamal S. *Front Psychiatry*. 2023 May 11;14:1130989.\u003cbr\u003e6. Fan N, et al. *Hum Psychopharmacol*. 2017 Jul;32(4).\u003cbr\u003e7. Fan C, et al. *Neuroscience*. 2018 Nov 10;392:92-106.\u003cbr\u003e8. Wang Z, et al. *Behav Brain Res*. 2014 Nov 1;274:282-90.\u003cbr\u003e9. Sasaki H, et al. *Biol Pharm Bull*. 2011;34(5):660-5.\u003cbr\u003e10. Small GW, et. al. *Am J Geriatr Psychiatry*. 2018 Mar;26(3):266-277\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or taking any medication, consult your healthcare professional before use. Keep out of the reach of children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Turmeric extract is derived from *Curcuma longa L*. rhizome and standardized for curcumin\u003cbr\u003e* Saffron extract is derived from *Crocus sativus* stigma and standardized for Lepticrosalides™\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275299868868,"sku":null,"price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/clm6_rgb_1.avif?v=1781887263"},{"product_id":"lipid-support-complex-60ct","title":"Lipid Support Complex 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports hepatic fat metabolism\u003cbr\u003e* Reduces oxidative stress\u003cbr\u003e* Supports vascular health\u003cbr\u003e* Promotes healthy uric acid levels\u003cbr\u003e* Clinically studied BergacynFF®\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily with meals, or as directed by a health care professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Patients seeking support for healthy liver fat metabolism\u003cbr\u003e* Patients seeking support for healthy uric acid levels or oxidative stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLipid Support Complex supports hepatic fat metabolism with a combination of berberine and clinically studied BergacynFF®, a patented extract blend of bergamot citrus and *Cynara cardunculus* . BergacynFF® supports lipid metabolism in the liver, with the added benefits of promoting healthy uric acid levels, decreasing oxidative stress and supporting vascular endothelial health.1-4 In a randomized, double blind, placebo-controlled clinical study involving 102 subjects, BergacynFF® (600 mg\/day) for 12 weeks resulted in significant support for liver fat metabolism, assessed by CAP scores.2 In a randomized, double blind, placebo-controlled clinical study involving 80 subjects, BergacynFF® (600 mg\/day) significantly improved serum markers of oxidative stress, with a reduction in circulating malondialdehyde (MDA) coupled with an increase in glutathione peroxidase (GPx) and superoxide disumutase (SOD) levels after 16 weeks. Supplementation also supported vascular endothelial function.^4^ This formula also provides berberine, an alkaloid that moderates lipid accumulation in liver cells in vitro.5-8 In preclinical models, berberine activates hepatic AMP kinase (AMPK) and sirutin 1 (SIRT1), which play important roles in supporting fat utilization in moderating fat synthesis in the liver.7, 8-10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. **Ferro** Y, et al. *Medicina (Kaunas)*. 2022 Nov 26;58(12):1728.\u003cbr\u003e2. **Ferro** Y, et al. *Front Endocrinol (Lausanne)*. 2020 Aug 11;11:494.\u003cbr\u003e3. **Parafati** M, et al. *J Nutr Biochem*. (2015) 26:938-- 48.\u003cbr\u003e4. **Musolino** V, et al. *J Tradit Complement Med*. 2020 Feb 8;10(3):268-274.\u003cbr\u003e5. **Xu** X, et al. *FASEB J*. 2019 Jun;33(6):7289-7300.\u003cbr\u003e6. **Ionita-Radu** F, et al. *Int J Mol Sci*. 2024 Apr 10;25(8):4201.\u003cbr\u003e7. **Yu** M, et al. *Int J Biol Sci*. 2021 Apr 12;17(7):1693-1707.\u003cbr\u003e8. **Zhu** X, et al. *Free Radic Biol Med*. 2019 Sep;141:192-204.\u003cbr\u003e9. **Smith** BK, et al. *Am J Physiol Endocrinol Metab*. 2016 Oct 1;311(4):E730-E740.\u003cbr\u003e10. **Tian** C, et al. *Pharmacol Res*. 2024 May;203:107155.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Bergamot orange extract is derived from *Citrus bergamia* fruit\u003cbr\u003e* Cardoon artichoke extract is derived from *Cynara cardunculus* leaf\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003cbr\u003e* Tri-magnesium citrate is derived from elemental ore and non-GMO glucose fermentation from non-GMO maize, molasses, and sugar beet or sugar cane\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275299901636,"sku":null,"price":60.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/lsc6_rgb.avif?v=1781887474"},{"product_id":"creatine-11-1oz","title":"Creatine 11.1oz","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports muscle strength, performance and recovery\u003cbr\u003e* Promotes growth factor signaling and glycogen storage to support gains in muscle strength\u003cbr\u003e* Supports quick conversion of ADP to ATP energy\u003cbr\u003e* Helps reduce recovery time\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eTake this product with an adequate daily fluid intake. Mix 1 ½ tsp daily with 8 oz of water or beverage of choice. For best results, take this product with a carbohydrate-containing beverage or food 30 minutes before exercise, or immediately following exercise. On rest days, take 1 serving daily with a meal or as directed.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* For athletes and active adults engaged in strength training programs, strenuous exercise, or sports requiring repeated bursts of speed, power or strength\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eCreatine is clincally studied to increase body strength, build muscle mass, and support recovery from strenuous exercise. Creatine may increase fat free mass and muscle morphology with concurrent heavy resistance training more than resistance training alone. It also may be of benefit in other modes of exercise such as high-intensity sprints or dynamic movements for improved performance.1-8\u003c\/p\u003e\n\u003cp\u003eCreatine is an energy carrier that is naturally present in muscles, brain and other organs. In muscles, creatine in the form of phosphorylcreatine acts as a reserve of high-energy phosphate to provide energy during anaerobic exercise by regenerating ADP to ATP. By increasing the rate of creatine phosphorylation, ammonia and lactate levels in the blood are lowered resulting in faster recovery from exercise. Creatine also promotes growth factor signaling and glycogen storage to support gains in muscle strength, size and other adaptive responses to training.\u003c\/p\u003e\n\u003cp\u003eSince creatine plays other vital roles within the musculoskeletal and nervous systems, it is essential for many aspects of health. Animal muscle -- such as fresh meat and fish -- contains significant amounts of creatine. Dairy products contain only small amounts. Since vegetables, grains, nuts and pulses do not contain creatine, vegetarians are more likely to have suboptimal levels than meat eaters.\u003c\/p\u003e\n\u003cp\u003eThe recommended dose for creatine monohydrate is 3 - 5 grams per day. At this dosage, creatine levels in the body will typically rise for three or four weeks before leveling off. With this approach, a loading phase is not needed.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Buford et al. Scand J Med Sci Sports. 2007;4(6).\u003cbr\u003e2. Skare et al. Scand J Med Sci Sports. 2001;11(2).\u003cbr\u003e3. Cooper R, Naclerio F, Allgrove J, Jimenez A. J Int Soc Sports Nutr. 2012; 9: 33.\u003cbr\u003e4. Becque MD, Lochmann JD, Melrose DR. Med Sci Sports Exerc. 2000 Mar;32(3):654-8.\u003cbr\u003e5. Aaserud R, Gramvik P, Olsen SR, Jensen J. Scand J Med Sci Sports. 1998 Oct;8(5 Pt 1):247-51.\u003cbr\u003e6. Izquierdo M1, Ibañez J, González-Badillo JJ, Gorostiaga EM. Med Sci Sports Exerc. 2002 Feb;34(2):332-43.\u003cbr\u003e7. McConell GK, Shinewell J, Stephens TJ, et al. Med Sci Sports Exerc. 2005;37(12), 2054.\u003cbr\u003e8. Hespel P, Derave W. Subcell Biochem. 2007;46:245-59.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eConsult your healthcare practitioner before use if pregnant, lactating, on medication or have any health condition, including kidney disease. Not intended for use by persons under the age of 18.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place. **Important Notice: No Scoop Included** As part of our commitment to sustainability, we want to inform you that our creatine powder does not come with a plastic scoop. Instead, we recommend measuring a serving size of 1.5 teaspoons using a regular teaspoon from your kitchen.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eCreatine monohydrate is synthetically sourced\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275299934404,"sku":null,"price":35.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/crm6.avif?v=1781887550"},{"product_id":"pure-sleep-60ct","title":"Pure Sleep 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps your patients fall asleep, stay asleep, and wake up refreshed without morning grogginess\u003cbr\u003e* Improves sleep quality, efficiency and duration with continued use\u003cbr\u003e* Helps relieve occasional stress and anxiety\u003cbr\u003e* Supports a healthy cortisol response\u003cbr\u003e* Melatonin free\u003cbr\u003e* Clinically studied ashwagandha (KSM-66)\u003cbr\u003e* Clinically studied saffron (affron®)\u003cbr\u003e* Clinically studied valerian root (Sleeproot)\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 30-60 minutes before bedtime.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* For patients seeking support for sleep onset and\/or duration\u003cbr\u003e* For patients requesting a melatonin-free product\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePure Sleep combines three clinically studied botanical extracts to help patients fall asleep, stay asleep and experience the restorative, restful sleep they need without morning grogginess. KSM-66 ® ashwagandha (*Withania somnifera* ) root extract is a calming adaptogen that helps relieve occasional stress and anxiety and supports a healthy cortisol response.1, 2 Results from several randomized, placebo-controlled trials indicate that KSM-66 ® supports sleep onset, helping individuals fall asleep faster, while enhancing sleep quality and efficiency when taken continuously over several weeks.2-4 In a randomized, double blind clinical trial involving 80 adults, ashwagandha supplementation (KSM-66 ®, 300 mg twice daily) for 8 weeks led to a significant mean reduction in sleep onset latency (the time it takes to fall asleep after going to bed), sleep quality, and total sleep time.3 A 12- week randomized, double blind clinical trial demonstrated that ashwagandha (KSM-66 ®, 300 mg twice daily) improved subjective sleep parameters and mental alertness on rising, in healthy elderly subjects.4 Results from multiple clinical trials demonstrate that saffron extract (affron ®) promotes multiple aspects of restful sleep, supporting sleep onset and duration with continued use.5-7 In a randomized, double blind clinical trial involving 66 adults, saffron (affron ®, 15.5 mg per day) for 6 weeks led to significant improvements in ease of getting to sleep, sleep quality, sleep duration, and global Pittsburgh Sleep Quality Index (PSQI) scores.5 In a randomized double-blind, placebo controlled trial involving 63 healthy adults aged 18-70 with self-reported sleep concerns, saffron (affron ®, 14 mg twice daily) for 28 days led to greater improvements in Restorative Sleep Questionnaire (RSQ) total scores and the Pittsburgh Sleep Diary (PSD) sleep quality ratings compared to placebo.6 This formula also provides Sleeproot, a valerian root extract standardized to a higher potency (2% total valerenic acids) than typical extracts, that promotes sleep quality, efficiency and duration. In a randomized, double blind clinical trial involving 72 adults, Sleeproot (200 mg\/day) for 8 weeks improved overall sleep quality, reduced sleep latency, enhanced sleep efficiency, and prolonged total sleep time. Sleeproot resulted in significant improvements in mean total PSQI sleep scores and reduced sleep latency, assessed by wrist actigraphy, compared to placebo.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Salve J, et al. *Cureus* 2019 Dec 25;11(12):e6466.\u003cbr\u003e2. Langade D, et al. *Cureus* 2019; 11(9): e5797.\u003cbr\u003e3. Langade D, et al. *J Ethnopharmacol*. 2021; 264: 113276.\u003cbr\u003e4. Kelgane SB, et al. *Cureus* 2020; 12(2): e7083.\u003cbr\u003e5. Pachikian BD, et al. *Nutrients* 2021 Apr 27;13(5):1473.\u003cbr\u003e6. Lopresti AL, et al. *J Clin Sleep Med*. 2020 Jun 15;16(6):937-947.\u003cbr\u003e7. Lopresti AL, et al. *Sleep Med*. 2021 Oct;86:7-18.\u003cbr\u003e8. Shekhar CH, et al. Adv Ther. 2024 Jan;41(1):246-261.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken if you are pregnant or lactating. Consult your healthcare practitioner before use if on any medication or have any health condition. Discontinue use and seek medical advice if adverse reaction occur. Product may impair ability to drive a motor vehicle or operate machinery.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ashwagandha extract is derived from *Withania somnifera* root\u003cbr\u003e* Valerian extract is derived from *Valeriana officinalis* root\u003cbr\u003e* Theanine is derived from fermentation\u003cbr\u003e* Saffron is derived from *Crocus sativus* stigma extract\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003cbr\u003e* Tri-magnesium citrate is derived from elemental ore and non-GMO glucose fermentation from non-GMO maize, molasses, and sugar beet or sugar cane\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275299967172,"sku":null,"price":52.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/psl6_rgb.avif?v=1781887673"},{"product_id":"femivive-120ct","title":"FemiVive 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eEnhances sexual satisfaction and pleasure\u003cbr\u003eImproves arousal, lubrication and orgasm\u003cbr\u003eImproves quality of sex\u003cbr\u003eWith KSM-66 Ashwagandha®, clinically shown to enhance physical and psychological aspects of female sexual response with continued use\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eFor women seeking support for libido and sexual function\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eFemiVive provides KSM-66 ashwagandha®, an Ayurvedic botanical clinically shown to enhance sexual arousal, lubrication, pleasure, orgasm, and satisfaction in women.1, 2 In a randomized, placebo-controlled study involving 80 women between 18 and 50 years of age, KSM-66 Ashwagandha® (300 mg twice daily) for 8 weeks resulted in significant improvement in Female Sexual Function Index (FSFI) mean total scores and sub-scales of desire, arousal, lubrication, orgasm, and sexual satisfaction compared to placebo.1 In another randomized, placebo-controlled study involving 50 women between 21 and 50 years of age, KSM-66 Ashwagandha® (300mg twice daily) for 8 weeks also improved scores in the Female Sexual Function Index (FSFI) total and sub-domain scores for arousal, lubrication, orgasm and satisfaction.2 The group receiving KSM-66 also exhibited a greater number of successful sexual encounters compared to the placebo group.2 This formula also provides maca (Lepidium meyenii ) root, also known as Peruvian ginseng, which is known for its adaptogenic properties.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Ajgaonkar A, Jain M, Debnath K. Cureus. 2022 Oct 28;14(10):e30787.\u003cbr\u003e2. Dongre S, Langade D, Bhattacharyya S. Biomed Res Int. 2015;2015:284154.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eMaca extract is derived from Lepidium meyenii tuber and standardized for glucosinolates\u003cbr\u003eTribulus terrestris extract is derived from the leaf and fruit and standardized for protodioscins\u003cbr\u003eAshwagandha extract is derived from Withania somnifera root\u003cbr\u003eAscorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003eHypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300032708,"sku":null,"price":53.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/fmv1_rgb.avif?v=1781887785"},{"product_id":"dao-enzyme-60ct","title":"DAO Enzyme 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes breakdown of dietary histamine\u003cbr\u003e* Reduces gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods\u003cbr\u003e* Eat with greater confidence when histamine may be present in food\u003cbr\u003e* Acid-resistant capsules protect DAO from degradation in the stomach\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2-3 times daily, with each meal, or as directed by a health care professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Individuals who experience symptoms of histamine intolerance, such as occasional GI upset, skin sensitivity or flushing\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eHistamine is a substance found in many foods, such as meats, spinach, fermented foods, avocadoes, nuts, tomatoes and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently, often because of low intestinal diamine oxidase (DAO), an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort, headache, skin sensitivity or flushing after consuming histamine-containing foods.1 Supplementation with DAO enhances DAO activity in the GI tract, promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods.3 DAO may also reduce skin symptoms associated with high intestinal histamine levels.6 In an open-label pilot study, individuals with low DAO levels (\u0026lt; 10 U\/ml) who received DAO (10, 000 HDU) up to 3 times per day reported significant improvements in gastrointestinal, respiratory and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort, including occasional diarrhea, bloating and gas, headache, respiratory and skin discomfort.3 In a double-blind, placebo-controlled, crossover investigation of 22 patients, supplementation of 10, 000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort.6 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Biomolecules. 2020 Aug 14;10(8):1181.\u003cbr\u003e2. Sánchez-Pérez S, Comas-Basté O, Costa-Catala J, et al. Front Nutr. 2022 May 25;9:897028.\u003cbr\u003e3. Schnedl WJ, Schenk M, Lackner S, et al. Food Sci Biotechnol. 2019; 28(6): 1779-1784.\u003cbr\u003e4. Manzotti G., Breda D., Di Gioacchino M., Burastero S.E. Int J Immunopathol Pharmacol. 2016;29:105--111.\u003cbr\u003e5. Komericki P., Klein G., Reider N., et al. Wien Klin Wochenschr. 2011;123:15--20.\u003cbr\u003e6. Yacoub MR, et al. Int Arch Allergy Immunol. 2018;176(3-4):268-271.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Diamine oxidase is porcine-derived\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300065476,"sku":null,"price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e8bb7b9b3a7b573638ea664f035cbc51930eca5e0fbc75f914f68fcb35fc5f89.avif?v=1781887944"},{"product_id":"muscle-repair-60ct","title":"Muscle Repair+ 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Clinically shown to enhance muscle cell repair from exercise\u003cbr\u003e* Supports cellular recovery from exercise-induced muscle damage\u003cbr\u003e* Clinically shown to enhance muscle stem cell activity\u003cbr\u003e* Clinically studied combination of nicotinamide (vitamin B3, 714 mg) and pyridoxine (vitamin B6, 19 mg)\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eActive adults and athletes seeking support for muscle repair\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eMuscle Repair+ is a studied combination of nicotinamide (vitamin B3) and pyridoxine (vitamin B6) that accelerates muscle cell repair, recovery and regeneration after exercise. Nicotinamide and pyridoxine were recently identified as bioactive nutrients that enhance the activation and differentiation of muscle stem cells, which enable skeletal muscles to adapt, grow and regenerate in response to exercise.1 The clinical efficacy of this combination was evaluated in a randomized, double blind, placebo-controlled trial of 42 healthy men between 18-50 years of age, who received the combination of niacinamide (714 mg) and pyridoxine (19 mg) or placebo for 8 days following eccentric exercise-induced muscle damage triggered by electrical stimulation. Supplementation significantly increased the proportion of actively regenerating muscle fibers relative to placebo after 8 days of daily use following exercise induced muscle damage. The supplemented group exhibited a 35% greater number of activated muscle stem cells and a 14% mean increase in muscle fiber recovery rate compared to the placebo group.2 This formula is ideal for active adults and athletes seeking support for muscle repair.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Ancel S, Michaud J, Migliavacca E, et al. J Clin Invest. 2024 Nov 12;134(24):e163648.\u003cbr\u003e2. Feige JN, et al (2024). Manuscript in preparation.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant, feeding a baby your breastmilk, taking any medication, or have any health condition, consult your healthcare practitioner before use. Discontinue use and consult your healthcare practitioner if any adverse reactions occur.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Niacinamide and vitamin B6 (pyridoxine HCl) are synthetic\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300196548,"sku":null,"price":27.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/mrp6_rgb_1.avif?v=1781888035"},{"product_id":"calcium-magnesium-malate-2-1-180ct","title":"Calcium Magnesium (malate) 2:1 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003ePromotes bone health and may reduce the risk of osteoporosis\u003cbr\u003eSupports cardiovascular health by maintaining electrolyte balance\u003cbr\u003eMay help promote healthy lipid metabolism\u003cbr\u003eContains chelated minerals for optimal absorption\u003cbr\u003eMade with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 3 capsules, 1-2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eBone health support\u003cbr\u003eCardiovascular health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eCombines di-calcium malate and di-magnesium malate for the highest elemental calcium and magnesium per capsule. These minerals are chelated with the krebs cycle intermediate malate for optimal absorption. Randomized, double-blind, placebo-controlled studies have reported statistically significant benefits of calcium supplementation for bone health1, 2 Magnesium, like calcium, is an essential bone matrix mineral that promotes healthy bone metabolism.3 A trial involving 2, 038 older individuals indicated that higher intakes of magnesium were positively associated with bone mineralization for certain individuals.4 Supplementation with calcium and magnesium provides synergistic support for bone health.5 Magnesium supports cardiovascular health by helping to maintain healthy levels of cellular and plasma electrolytes, including calcium and potassium.6 Additionally, calcium and magnesium may help to promote healthy lipid metabolism.7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Reid IR, et al.*Am J Med.* 2006 Sep;119(9):777- 85.\u003cbr\u003e2. Reid IR, et al.*Arch Intern Med.* 2008 Nov 10;168(20):2276-82.\u003cbr\u003e3. Tonya S, et al. *Am J Clin Nutr.* 2014 Apr; 99(4): 926?933.\u003cbr\u003e4. Ryder KM, et al.*J Am Geriatr Soc.* 2005 Nov;53(11):1875-80.\u003cbr\u003e5. Abraham GE, et al. *J Reprod Med.* 1990 May;35(5):503-7.\u003cbr\u003e6. Shechter M, et al. *Am J Cardiol.* 2003 Mar 1;91(5):517-21.\u003cbr\u003e7. Reid IR, et al. *Am J Med.*2002 Apr 1;112(5): 343-7.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eCalcium and magnesium are derived from the lime of rock\u003cbr\u003eMalate is synthetic\u003cbr\u003eAscorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300360388,"sku":null,"price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/081e5e4796d3a9294f6be80ecc413e603e35b3c3e499d527c19fab1cda56709d_76a94c30-511b-493c-8d96-2d7ec7f3c4bc.avif?v=1781888163"},{"product_id":"women-s-nutrients-60ct","title":"Women's Nutrients 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eProvides essential vitamins, minerals and nutrients based on scientific recommendations for young women and adults\u003cbr\u003eSupports hormone, neurotransmitter, DNA, protein and energy production‡\u003cbr\u003ePromotes optimal neural and cellular development\u003cbr\u003eFormulated with the optimal chelated minerals, active vitamins and the right functional ingredients to support a modern lifestyle\u003cbr\u003eWith Metafolin® L-5-MTHF the naturally occurring, universally metabolized form of folate\u003cbr\u003eWith 27 mg of iron to support the needs of young women and adults\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eFor young women and adults\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eWomen's Nutrients provides vitamins and minerals needed to support the needs of women of childbearing age, including women who are pregnant, may become pregnant or are lactating.1, 2 It's best to consider using this formula along with EPA\/DHA. This formula provides 1 mg of Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF) to support optimal neural and cellular development. Metafolin® is a naturally occurring, universally metabolized form of folate.3-5 The vitamin D included in our formula comes from an algae-derived vegan source. Women's Nutrients also includes vitamin K to support healthy carboxylation of proteins for blood-clotting and bone health.5 The iron (27 mg) in our formula promotes optimal iron status and supports cognitive function.7, 8 Optimal iron status is also associated with athletic performance and mitochondrial function.9, 10 Choline (100 mg) is included in our formula because it contributes to neurotransmitter production, DNA synthesis, protein metabolism, energy metabolism and fetal central nervous system development.11\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Keen CL, Zidenberg-Cherr S. Am J Clin Nutr. 1994 Feb;59(2 Suppl):532S-538S.\u003cbr\u003e2. Kominiarek MA, Rajan P. Med Clin North Am. 2016 Nov;100(6):1199-1215.\u003cbr\u003e3. Hashemipour S, et al. Br J Nutr. 2013 Nov 14;110(9):1611-6.\u003cbr\u003e4. Prinz-Langenohl R, et al. Br J Pharmacol. 2009 Dec; 158(8): 2014--2021.\u003cbr\u003e5. Milunsky A. JAMA. 1989 Nov 24;262(20):2847-52.\u003cbr\u003e6. Shearer MJ, et al. J Nutr. 1996 Apr;126(4 Suppl):1181S-6S.\u003cbr\u003e7. Jáuregui-Lobera I. Neuropsychiatr Dis Treat. 2014 Nov 10;10:2087-95.\u003cbr\u003e8. McClung JP, Murray-Kolb LE. Annu Rev Nutr. 2013;33:271-88.\u003cbr\u003e9. Solberg A, Reikvam H. Life (Basel). 2023 Oct 2;13(10):2007.\u003cbr\u003e10. Paul BT, et al. Expert Rev Hematol. 2017 Jan;10(1):65-79.\u003cbr\u003e11. Meck, WH, et al. Neurosci Biobehav Rev. 27 (2003) 385--399\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eBeta carotene: *Blakeslea trispora*\u003cbr\u003eLycopene: natural tomato concentrate\u003cbr\u003eLutein: marigold flower extract\u003cbr\u003eZeaxanthin: synthetic\u003cbr\u003eVitamin C: corn dextrose fermentation\u003cbr\u003eVitamin E: soybean\u003cbr\u003eVitamin D3: algae\u003cbr\u003eVitamin K1: synthetic\u003cbr\u003eVitamin B1 (thiamine HCl): synthetic\u003cbr\u003eVitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003eNiacinamide: synthetic\u003cbr\u003eVitamin B5 (calcium pantothenate): synthetic\u003cbr\u003eVitamin B6 (pyridoxal HCl): synthetic\u003cbr\u003eVitamin B12 (methylcobalamin): corn dextrose fermentation\u003cbr\u003eFolate: synthetic\u003cbr\u003eBiotin: synthetic\u003cbr\u003eCholine: synthetic\u003cbr\u003eMinerals: naturally derived from earthen ore\u003cbr\u003eSources of the mineral chelates include:\u003cbr\u003eCitrate: corn dextrose fermentation\u003cbr\u003eGlycinate: synthetic\u003cbr\u003ePolynicotinate: synthetic\u003cbr\u003eMixed carotenoid profile typically contains 4, 800 mcg beta carotene, 133 mcg lycopene, 265 mcg lutein and 53 mcg zeaxanthin\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300491460,"sku":null,"price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/wmn6_rgb.avif?v=1781888266"},{"product_id":"vitamin-d3-k2-60ct","title":"Vitamin D3 \u0026 K2 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003ePromotes healthy calcium utilization to maintain bone health\u003cbr\u003eSupports vascular tissue to support healthy arterial calcium balance and vascular elasticity\u003cbr\u003eSupports immune function with vitamin D3\u003cbr\u003eProvides vitamin D3 and vitamin K2 in one convenient capsule\u003cbr\u003e100 mcg of biologically active all-trans vitamin K2 (MK-7) per capsule\u003cbr\u003eMade with hypoallergenic ingredients\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eBone and vascular health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVitamin K2 (menaquinone-7) is a fat-soluble nutrient with an important role in maintaining arterial calcium balance and vascular elasticity.1-12 In a systematic review involving five studies, higher intakes of vitamin K2 were associated with cardiovascular health.10 In an observational study involving 564 postmenopausal women, higher intake of vitamin K2 was associated with calcium balance in the vascular tissue.8 One of the primary functions of vitamin K2 is to support the carboxylation of matrix Gla-protein (MGP), a key protein involved in calcium balance.11 Accordingly, several studies indicate that Vitamin K2 also supports proper utilization of calcium in bone. Clinical research indicates that obtaining adequate amounts helps to maintain bone health.1-6 Vitamin K2 and vitamin D3 both participate in the regulation of osteocalcin, a biomarker of bone formation.1, 13\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Gropper SAS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism. 5th Ed. Chapter 10, pp. 412-414. Wadsworth\/Cengage Learning, Australia. c.2009.\u003cbr\u003e2. El Borolossy R, El-Farsy MS. Eur J Clin Nutr. 2022 Jun;76(6):848-854.\u003cbr\u003e3. Qiu C, Zheng H, Tao H, et al. Mol Cell Biochem. 2017 Sep;433(1-2):149-159.\u003cbr\u003e4. Yamaguchi M, Sugimoto E, Hachiya S. Mol Cell Biochem. 2001 Jul;223(1-2):131-7.\u003cbr\u003e5. Zhang Y, Liu Z, Duan L, et al. Calcif Tissue Int. 2020 May;106(5):476-485.\u003cbr\u003e6. Knapen MH, Drummen NE, Smit E, et al. Osteoporos Int. 2013 Sep;24(9):2499-507.\u003cbr\u003e7. Knapen MH, Braam LA, Drummen NE, et al. Thromb Haemost. 2015 May;113(5):1135-44.\u003cbr\u003e8. Beulens JW, Bots ML, Atsma F, et al. Atherosclerosis. 2009 Apr;203(2):489-93.\u003cbr\u003e9. Mansour AG, Hariri E, Daaboul Y, et al. J Am Soc Hypertens. 2017 Sep;11(9):589-597.\u003cbr\u003e10. Rees K, Guraewal S, Wong YL, et al. Maturitas. 2010 Oct;67(2):121-8.\u003cbr\u003e11. Dalmeijer GW, van der Schouw YT, Magdeleyns E. Atherosclerosis. 2012 Dec;225(2):397-402.\u003cbr\u003e12. Vermeer C and Vik H. Vascul Dis Ther. 2020;5: doi: 10.15761\/VDT.1000179.\u003cbr\u003e13. Gigante A, Brugè F, Cecconi S, et al. J Tissue Eng Regen Med. 2015 Jun;9(6):691-701.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use. It is recommended that individuals taking more than 50 mcg (2, 000 IU) vitamin D per day have their blood levels monitored.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eVitamin K2 (MK-7) is derived from flower extracts geraniol and farnesol\u003cbr\u003eVitamin D3 is derived from lanolin\u003cbr\u003eHypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300720836,"sku":null,"price":19.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/a14160d014d9b1ec0ac755d66ab2c07681ecb6b2741f47c7086392a1ba54b4c0_1.avif?v=1781888369"},{"product_id":"vitamin-d3-k2-120ct","title":"Vitamin D3 \u0026 K2 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003ePromotes healthy calcium utilization to maintain bone health\u003cbr\u003eSupports vascular tissue to support healthy arterial calcium balance and vascular elasticity\u003cbr\u003eSupports immune function with vitamin D3\u003cbr\u003eProvides vitamin D3 and vitamin K2 in one convenient capsule\u003cbr\u003e100 mcg of biologically active all-trans vitamin K2 (MK-7) per capsule\u003cbr\u003eMade with hypoallergenic ingredients\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eBone and vascular health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVitamin K2 (menaquinone-7) is a fat-soluble nutrient with an important role in maintaining arterial calcium balance and vascular elasticity.1-12 In a systematic review involving five studies, higher intakes of vitamin K2 were associated with cardiovascular health.10 In an observational study involving 564 postmenopausal women, higher intake of vitamin K2 was associated with calcium balance in the vascular tissue.8 One of the primary functions of vitamin K2 is to support the carboxylation of matrix Gla-protein (MGP), a key protein involved in calcium balance.11 Accordingly, several studies indicate that Vitamin K2 also supports proper utilization of calcium in bone. Clinical research indicates that obtaining adequate amounts helps to maintain bone health.1-6 Vitamin K2 and vitamin D3 both participate in the regulation of osteocalcin, a biomarker of bone formation.1, 13\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Gropper SAS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism. 5th Ed. Chapter 10, pp. 412-414. Wadsworth\/Cengage Learning, Australia. c.2009.\u003cbr\u003e2. El Borolossy R, El-Farsy MS. Eur J Clin Nutr. 2022 Jun;76(6):848-854.\u003cbr\u003e3. Qiu C, Zheng H, Tao H, et al. Mol Cell Biochem. 2017 Sep;433(1-2):149-159.\u003cbr\u003e4. Yamaguchi M, Sugimoto E, Hachiya S. Mol Cell Biochem. 2001 Jul;223(1-2):131-7.\u003cbr\u003e5. Zhang Y, Liu Z, Duan L, et al. Calcif Tissue Int. 2020 May;106(5):476-485.\u003cbr\u003e6. Knapen MH, Drummen NE, Smit E, et al. Osteoporos Int. 2013 Sep;24(9):2499-507.\u003cbr\u003e7. Knapen MH, Braam LA, Drummen NE, et al. Thromb Haemost. 2015 May;113(5):1135-44.\u003cbr\u003e8. Beulens JW, Bots ML, Atsma F, et al. Atherosclerosis. 2009 Apr;203(2):489-93.\u003cbr\u003e9. Mansour AG, Hariri E, Daaboul Y, et al. J Am Soc Hypertens. 2017 Sep;11(9):589-597.\u003cbr\u003e10. Rees K, Guraewal S, Wong YL, et al. Maturitas. 2010 Oct;67(2):121-8.\u003cbr\u003e11. Dalmeijer GW, van der Schouw YT, Magdeleyns E. Atherosclerosis. 2012 Dec;225(2):397-402.\u003cbr\u003e12. Vermeer C and Vik H. Vascul Dis Ther. 2020;5: doi: 10.15761\/VDT.1000179.\u003cbr\u003e13. Gigante A, Brugè F, Cecconi S, et al. J Tissue Eng Regen Med. 2015 Jun;9(6):691-701.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use. It is recommended that individuals taking more than 50 mcg (2, 000 IU) vitamin D per day have their blood levels monitored.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eVitamin K2 (MK-7) is derived from flower extracts geraniol and farnesol\u003cbr\u003eVitamin D3 is derived from lanolin\u003cbr\u003eHypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300851908,"sku":null,"price":35.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/a14160d014d9b1ec0ac755d66ab2c07681ecb6b2741f47c7086392a1ba54b4c0_3.avif?v=1781888507"},{"product_id":"rapid-mental-energy-30ct","title":"Rapid Mental Energy 30ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Sharpens working memory\u003cbr\u003e* Supports alertness\u003cbr\u003e* Supports cognitive performance\u003cbr\u003e* Two clinically backed ingredients\u003cbr\u003e* Not known to interfere with sleep\u003cbr\u003e* Can be safely used with caffeine\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* As-needed support for alertness and working memory\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRapid Mental Energy combines clinically studied extracts, Alpinia galanga (enXtra) and American ginseng (Cereboost®), to support alertness and sharpen working memory.1-5 In a randomized, double-blind, placebo-controlled crossover study, enXtra significantly increased alertness scores from baseline values at 1 hour, 3 hours and 5 hours after a single 300 mg dose.1 Alertness scores were significantly greater in the enXtra group compared to placebo (p=0.04) at 3 hours post-dose. While enXtra supports alertness and attention network function (the ability to direct mental resources to a specific task), Cereboost® provides fast-acting support for acute visuospatial and verbal short-term (working) memory.1-5 in a study of 52 healthy middle-aged adults, Cereboost® (200 mg) improved working memory 3 hours after a single dose2 In a randomized controlled clinical trial of 61 healthy young adults, daily use of Cereboost® (200 mg) improved working memory and attention.3 In a randomized, double-blind crossover trial of 32 healthy volunteers, a single dose of Cereboost® (200 mg) improved working memory (immediate word recall and visuo-spatial information retrieval) at 1 hour post-dose and was sustained over a 6 hour testing period.4 The ginsenosides in Cereboost® support cholinergic neurotransmission in the hippocampus and prefrontal cortex, key brain regions involved in learning and memory.5 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Srivastava S, Mennemeier M, Pimple S. J Am Coll Nutr. 2017 Nov-Dec;36(8):631-639. doi: 10.1080\/07315724.2017.1342576.\u003cbr\u003e2. Bell L, Whyte A, Duysburgh C, et al. Eur J Nutr. 2022 Feb;61(1):413-428.\u003cbr\u003e3. Ossoukhova A, Owen L, Savage K, et al. Human Psychopharmacol. 2015;30(2):108--122.\u003cbr\u003e4. Scholey A, Ossoukhova A, Owen L, et al. Psychopharmacology. 2010;212(3):345--356.\u003cbr\u003e5. Shin K, Guo H, Cha Y, et al. Regul Toxicol Pharmacol. 2016 Jul;78:53-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* *Alpinia galanga* extract is derived from the rhizome\u003cbr\u003e* American ginseng is derived from *Panax quinquefolius* L. root extract and standardized for ginsenosides\u003cbr\u003e* Ginkgo is derived from *Ginkgo biloba* leaf extract and standardized for ginkgoheterosides and terpene lactones\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300884676,"sku":null,"price":35.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/rme3.avif?v=1781888572"},{"product_id":"daily-calm-60ct","title":"Daily Calm 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports relaxation with continued use\u003cbr\u003e* Supports a positive mood\u003cbr\u003e* Supports a relaxed and alert mental state\u003cbr\u003e* Supports sleep with continued use\u003cbr\u003e* Clinically studied L-theanine (Suntheanine®)\u003cbr\u003e* Clinically studied ashwagandha (KSM-66®)\u003cbr\u003e* Clinically studied saffron (affron®)\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional anxiety\u003cbr\u003e* Occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eDaily Calm combines L-theanine, saffron, GABA, and ashwagandha to relieve occasional stress and anxiety while supporting a positive, relaxed mood and emotional well-being. Suntheanine®, a trademarked L-theanine, supports a relaxed and alert mental state. A four-week randomized clinical trial using L-theanine found support for stress-related symptoms.1 Clinical research shows that saffron, a widely studied spice derived from the flower of *Crocus sativus* , supports emotional well-being and positive mood.2-4 Clinical studies also show that saffron supports sleep with continued use.5, 6 Ashwagandha, an adaptogenic herb, helps the body adapt to stress by restoring balance. Studies show that ashwagandha supports a calm, relaxed mood, helping to relieve occasional anxiety and stress.7-9 Together, these ingredients support multiple aspects of emotional wellness, helping to relieve occasional stress and anxiety while supporting a positive emotional outlook and sleep quality with continued use.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Hidese S, Ogawa S, Ota M, et al. *Nutrients*. 2019 Oct 3;11(10):2362.\u003cbr\u003e2. Tóth B, Hegyi P, Lantos T, et al. *Planta Med.* 2019 Jan;85(1):24-31. doi: 10.1055\/a-0660-9565.\u003cbr\u003e3. Kashani L, Eslatmanesh S, Saedi N, et al. *Pharmacopsychiatry*. 2017 Mar;50(2):64-68. doi: 10.1055\/s-0042-115306.\u003cbr\u003e4. Kell G, Rao A, Beccaria G, et al. *Complement Ther Med*. 2017 Aug;33:58-64. doi: 10.1016\/j.ctim.2017.06.001.\u003cbr\u003e5. Pachikian BD, Copine S, Suchareau M, Deldicque L. *Nutrients*. 2021 Apr 27;13(5):1473. doi: 10.3390\/nu13051473.\u003cbr\u003e6. Lopresti AL, Smith SJ, Metse AP, Drummond PD. *J Clin Sleep Med.* 2020 Jun 15;16(6):937-947. doi: 10.5664\/jcsm.8376.\u003cbr\u003e7. Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. *Cureus*. 2019 Sep 28;11(9):e5797. doi: 10.7759\/cureus.5797.\u003cbr\u003e8. Salve J, Pate S, Debnath K, Langade D. *Cureus*. 2019 Dec 25;11(12):e6466.\u003cbr\u003e9. Kelgane SB, Salve J, Sampara P, Debnath K. Cureus 2020; 12(2): e7083.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ashwagandha extract is derived from *Withania somnifera* root and standardized for withanolides\u003cbr\u003e* GABA (gamma-aminobutyric acid) and L-theanine are synthetic\u003cbr\u003e* Saffron is derived from *Crocus sativus* stigma extract and standardized for Lepticrosalides®\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300917444,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dcm6-1_1_1.avif?v=1781888648"},{"product_id":"rapid-calm-30ct","title":"Rapid Calm 30ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps to moderate general feelings of stress and occasional anxiety\u003cbr\u003e* Provides vitamin B6, a cofactor in the biosynthesis of serotonin\u003cbr\u003e* Contains clinically studied Zembrin®\u003cbr\u003e* Contains Suntheanine®, a clinically studied L-theanine\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Support for occasional anxiety in less than one hour\u003cbr\u003e* Support for occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRapid Calm delivers rapid-acting support for occasional anxiety in less than one hour. Zembrin®, a patented extract of *Sceletium tortuosum* , has been clinically studied and shown to help moderate general feelings of stress and occasional anxiety. In a clinical trial, a single dose of 25 mg Zembrin® reduced perceived levels of occasional anxiety and its physical symptoms, such as elevated heart rate, in healthy volunteers, within 1 hour.1 In another randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using pharmaco-fMRI.2 The amygdala is a part of the brain that reacts to threats and communicates with the rest of the related areas of the brain to regulate feelings of fear and nervousness in threatening situations. In vitro evidence indicates that Zembrin® might work by inhibiting serotonin reuptake, prolonging the effects of serotonin.3 Serotonin is a neurotransmitter involved in relaxation and mood. L-theanine complements Zembrin® by supporting a relaxed and alert mental state.4 Vitamin B6 is a cofactor in the biosynthesis of serotonin.5 This formula is ideal for as-needed relief from occasional everyday stressors.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Reay J, Wetherell MA, Morton E. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002\/hup.2753. Epub 2020 Aug 6. PMID: 32761980.\u003cbr\u003e2. Terburg D, Syal S, Rosenberger LA, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16. doi: 10.1038\/npp.2013.183.\u003cbr\u003e3. Harvey AL, Young LC, Viljoen AM, Gericke NP. J Ethnopharmacol. 2011 Oct 11;137(3):1124-9. doi: 10.1016\/j.jep.2011.07.035.\u003cbr\u003e4. Hidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390\/nu11102362.\u003cbr\u003e5. Blau N, Pearson TS, Kurian MA, et al. 2023 Oct 12. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach out children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin B6 and L-theanine are synthetic\u003cbr\u003e* *Sceletium tortuosum* is derived from aerial parts extract\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300950212,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/rcm3_rgb.avif?v=1781888719"},{"product_id":"cogniphos-120ct","title":"CogniPhos 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes daily cognitive performance and mental sharpness\u003cbr\u003e* Supports cellular energy and optimal neuronal function\u003cbr\u003e* Enhances healthy brain phospholipid composition\u003cbr\u003e* Contains a blend of clinically researched Cognizen® citicoline, acetyl-L-carnitine, Sharp-PS^®^ phosphatidylserine, and cofactors\u003cbr\u003e* Part of the PureSYNAPSE™ product line\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, with meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy cognitive function, positive mood and relaxation support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eAcetyl-l-carnitine (ALC) offers support for cellular energy, mood and neuronal function. A meta-analysis of 21 randomized controlled studies and 1, 204 older subjects indicated that ALC offered statistically significant support for memory, performance and higher intellectual function.1 In other trials involving children, ALC promoted daily mental function and behavior in a subset of subjects.2, 3 Citicoline and phosphatidylserine support healthy brain phospholipid composition. Phospholipids are essential for neuronal communication and protection. Research indicates that patented Cognizin® citicoline increases choline and phospholipid composition in the brain.4 Studies in children, middle-aged adults and elderly adults indicate that it supports healthy cognition across a wide age range. In two studies, one involving adolescent boys and another involving middle-aged women, 250-500 mg Cognizin® citicoline offered significant support for daily mental task performance.5, 6 Numerous studies indicate phosphatidylserine promotes healthy mental acuity and behavior in elderly subjects, as well as children.7, 8 Zinc and vitamin B6 are important cofactors for neuronal function.9, 10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Montgomery SA, et al. *Int Clin* Psychopharmacol. 2003 Mar;18(2):61-71.\u003cbr\u003e2. Arnold LE, et. al. *J Child Adolesc Psychopharmacol.*. 2007 Dec;17(6):791-802.\u003cbr\u003e3. Van Oudheusden LJ, et al. *Prostaglandins Leukot Essent Fatty Acids*. 2002 Jul;67(1):33-8.\u003cbr\u003e4. Silveri MM, et al. *NMR Biomed*. 2008 Nov;21(10):1066-75.\u003cbr\u003e5. McGlade E, et al. *J Atten Disord.*. 2015 Jul 15.\u003cbr\u003e6. McGlade E, et al. *Food and Nutrition Sciences,*, 2012, 3, 769-773.\u003cbr\u003e7. Kato-Kataoka A, et al. *J Clin Biochem Nutr*. 2010 Nov; 47(3): 246?255.\u003cbr\u003e8. Hirayama S, et al. *J Hum Nutr Diet.*. 2014 Apr;27 Suppl 2:284-91.\u003cbr\u003e9. Zamora J, et al. *Arch Latinoam Nutr*. 2011 Sep;61(3):242-6. Spanish.\u003cbr\u003e10. Deijen JB, et al. *Psychopharmacology (Berl)*. 1992;109(4):489-96.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Sharp-PS® GREEN phosphatidylserine is derived from sunflower lecithin\u003cbr\u003e* Cognizen® citicoline is derived from fermentation\u003cbr\u003e* Acetyl-l-carnitine and pyridoxyl 5' phosphate (vitamin B6) are synthetic\u003cbr\u003e* Citrate is derived from corn dextrose fermentation\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300982980,"sku":null,"price":85.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/5954e405ed84654b298c0f74e71af3f891546fa8642d77d7e338ae659cad46f0.avif?v=1781888799"},{"product_id":"l-glutamine-500-mg-90ct","title":"l-Glutamine 500 Mg. 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports gastrointestinal tract\u003cbr\u003e* Helps maintain intestinal integrity\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e500 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003e850 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003ePowder\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 heaping scoop mixed with water or juice, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Gastrointestinal tract integrity support\u003cbr\u003e* Tissue repair and immune system health\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003el-Glutamine is the most abundant amino acid in the body. In times of metabolic stress, glutamine is utilized by the body for tissue repair and gastrointestinal tract support.1, 2 Glutamine plays a large role in maintaining healthy intestinal integrity by enhancing the intestine's protective mucosal lining.3 In addition, glutamine is important in the preservation of muscle mass.4 Its effects on immune function may support post-exercise recovery.5, 6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Sasaki E, et al. *Luminescence.* 2013 Jul-Aug;28(4):442-9.\u003cbr\u003e2. Song QH, et al. *Int J Clin Pharmacol Ther.* 2015 May;53(5):372-6.\u003cbr\u003e3. Lima AA, et al. *Clinics (Sao Paulo).*2014;69(4):225-33.\u003cbr\u003e4. Rennie MJ, et al. *Metabolism.* 1989. 38(8); 47-51.\u003cbr\u003e5. Song QH, et al. *Int J Clin Pharmacol Ther.* 2015 May;53(5):372-6.\u003cbr\u003e6. Hiscock N, et al. *J Appl Physiol (1985).* 2003 Jul;95(1):145-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult yourhealth professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003el-Glutamine is derived from corn dextrose fermentation\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301015748,"sku":null,"price":24.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/d962718307d24a22d2a82f6a067a6f156bd791376e9331590432d5796ddce5a9.avif?v=1781888893"},{"product_id":"nr-longevity-60ct","title":"NR Longevity™ 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Age better by targeting the effects of aging from the inside, at the cellular level\u003cbr\u003e* Decreases the effects of cellular aging\u003cbr\u003e* Helps to replenish NAD+\u003cbr\u003e* Enhances mitochondrial function\u003cbr\u003e* Supports antioxidant defenses\u003cbr\u003e* Includes Nicotinamide riboside (NR) to promote the synthesis of NAD+, a key driver of cellular energy production\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Healthy aging support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eNR Longevity is specially designed to target biological processes that decline with age, such as the body's natural ability to make energy, build new mitochondria and protect cells from oxidative stress.1 Nicotinamide riboside (NR), resveratrol and sulforaphane promote healthy aging by replenishing NAD+, enhancing mitochondrial function and providing antioxidant support, respectively. Nicotinamide riboside (NR) is a form of vitamin B3 that acts as a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a critical role in cellular energy production.2-4 NAD+ activates enzymes in the sirtuin family, considered to be master switches of metabolism and regulators of aging. Notably, NAD+ activates SIRT1, an epigenetic switch that regulates metabolism and supports mitochondrial biogenesis, cellular energy production and cellular longevity.5, 6 Higher NAD+ levels are associated with healthy mitochondrial function.7, 8 Conversely, cellular NAD+ levels decline with age, and can decrease by up to 50% over the adult lifespan.7-11 Supplementing with NR enhances NAD+ levels, supporting the function of NAD+ dependent enzymes that maintain cellular energy production and repair. NR has been clinically shown to increase NAD+ levels in as little as 2 weeks.2 Resveratrol and sulforaphane promote longevity in model organisms.12-14 Both compounds enhance cellular antioxidant defenses, helping to protect cells against oxidative stress that increases with age and contributes to age-related cellular decline.1, 15-18 Resveratrol activates the AMPK\/SIRT1\/PGC-1alpha axis, a pathway that enhances mitochondrial function and supports normal cellular repair while sulforaphane activates Nrf2, a genomic switch that stimulates expression of genes involved in antioxidant defense, cellular protection and mitochondrial biogenesis.12, 13, 15-20 Nrf2 is a transcription factor that supports robust, long-lasting expression of numerous genes responsible for phase II detoxification and protection against oxidative stress. Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems.15-18 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Ghanim H, Sia CL, Abuaysheh S, et al. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8.\u003cbr\u003e2. Conze D, Brenner C, Kruger CL. Sci Rep. 2019 Jul 5;9(1):9772.\u003cbr\u003e3. Trammell SA, Schmidt MS, Weidemann BJ, et al. Nat Commun. 2016 Oct 10;7:12948.\u003cbr\u003e4. Covarrubias AJ, Perrone R, Grozio A, Verdin E. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.\u003cbr\u003e5. Chen C, Zhou M, Ge Y, Wang X. Mech Ageing Dev. 2020;Apr;187:111215.\u003cbr\u003e6. Tang BL. Mol Cells. 2016 Feb;39(2):87-95.\u003cbr\u003e7. Janssens GE, Grevendonk L, Perez RZ, et al. Nat Aging. 2022 Mar;2(3):254-263.\u003cbr\u003e8. Chu X, Raju RP. Metabolism. 2022; Jan;126:154923.\u003cbr\u003e9. Clement J, Wong M, Poljak A, et al. Rejuvenation Res. 2019 Apr;22(2):121-130.\u003cbr\u003e10. McReynolds MR, Chellappa K, Baur JA. Exp Gerontol. 2020 Feb 22;134:110888.\u003cbr\u003e11. Bratic A, Larsson NG. J Clin Invest. 2013 Mar;123(3):951-7.\u003cbr\u003e12. Howitz KT, Bitterman KJ, Cohen HY, et al. Nature. 2003;425:191--196.\u003cbr\u003e13. Wood JG, Rogina B, Lavu S, et al. Nature. 2004;430:686--689.\u003cbr\u003e14. Qi Z, Ji H, Le M, et al. Aging (Albany NY). 2021 Jan 20;13(2):1649-1670.\u003cbr\u003e15. Bai Y, Wang X, Zhao S, et al. Oxid Med Cell Longev. 2015;2015:407580.\u003cbr\u003e16. Calabrese EJ, Kozumbo WJ. Pharmacol Res. 2021 Jan;163:105283.\u003cbr\u003e17. Sun Y, Zhou S, Guo H, et al. Metabolism. 2020 Jan;102:154002.\u003cbr\u003e18. Zhao F, Zhang J, Chang N. Eur J Pharmacol. 2018 Apr 5;824:1-10.\u003cbr\u003e19. Timmers S, Konings E, Bilet L, et al. Cell Metab. 2011 Nov 2;14(5):612-22.\u003cbr\u003e20. Price NL, Gomes AP, Ling AJ, et al. Cell Metab. 2012 May 2;15(5):675-90.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Nicotinamide riboside chloride is synthetic\u003cbr\u003e* Broccoli sprout concentrate is derived from *Brassica oleracea italica* whole plant and standardized for sulforaphane\u003cbr\u003e* Trans-resveratrol is derived from Japanese knotweed (*Polygonum cuspidatum*) root extract\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301146820,"sku":null,"price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/bb0df18e6e7c8f6a7208d78c0fb029255f95ccafe82962660c7093ce2fc56a57.avif?v=1781888982"},{"product_id":"acerola-flavonoid-120ct","title":"Acerola\/Flavonoid 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Provides antioxidant support\u003cbr\u003e* Supports immune system function\u003cbr\u003e* Helps maintain healthy mast cell function and lymphocyte formation\u003cbr\u003e* Sourced from berries and citrus fruits\u003cbr\u003e* Corn-free and plant-based\u003cbr\u003e* Made with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-4 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Antioxidant and immune system support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis corn-free vitamin C and bioflavonoid blend contains 32% vitamin C sourced from natural acerola extract combined with the bioflavonoids quercetin, naringin and rutin for antioxidant support. Vitamin C is an important dietary antioxidant that supports the immune system, in part by maintaining healthy mast cell function and lymphocyte formation.1 The bioflavonoids quercetin, rutin and naringin are powerful free radical scavengers that complement the roles of vitamin C.2, 3\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Wintergerst ES, et al. *Ann Nutr Metab*. 2006;50(2):85-94.\u003cbr\u003e2. Boots AW, et al. Clin Nutr. 2011 Aug;30(4):506- 12. (dose)\u003cbr\u003e3. Grinberg LN, et al. Biochem Pharmacol. 1994 Aug 17;48(4):643-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Acerola extract is sourced from the berries of *Malpighia glabra L.*\u003cbr\u003e* Quercetin is derived from Fava d'anta tree (*Dimorphandra mollis* ) or Japanese pagoda tree (*Sophora Japonica* ) flower buds\u003cbr\u003e* Naringin is dervied from *Citrus grandis (L.)* Osbeck\u003cbr\u003e* Rutin is derived from Japanese pagoda tree (*Sophora Japonica* )\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301277892,"sku":null,"price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/d6288028353534dde11b50942f71d0ee2ddd7308928325c00bcebf1c68cb3066_1.avif?v=1781889099"},{"product_id":"amino-replete-8-5oz","title":"Amino Replete 8.5oz","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports athletic activity, cognitive function and daily wellness\u003cbr\u003e* Promotes immune function\u003cbr\u003e* Convenient powder formula for easy dispensing\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 scoop daily, mixed with 8 ounces of water or juice, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Daily wellness support\u003cbr\u003e* Athletic activity support\u003cbr\u003e* Immune and positive mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eOffers a comprehensive blend of free-form amino acids, provided in the ratios found naturally in high biological value (BV) protein sources. Maintains daily wellness with amino acid building blocks to support protein synthesis.1 Supports athletic training, including muscle performance, energy production and recovery.2 Enhances healthy neurotransmitter synthesis with amino acid precursors to support cognitive function and positive mood.3 Promotes immune function, in part by supporting healthy glutamine and glutathione levels.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Bukhari SS, et al. *Am J Physiol Endocrinol Metab.* 2015 Jun 15;308(12):E1056-65.\u003cbr\u003e2. Ohtani M, et al. *J Nutr*. 2006. 136: 538-43.\u003cbr\u003e3. Lehnert H, et al. *Psychother Psychosom*. 1993;60(1):18-32.\u003cbr\u003e4. Bassit RA, et al. *Med Sci Sports Exerc*. 2000 Jul;32(7):1214-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003ePHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* L-arginine, L-glutamine, L-histidine, L-lysine, L-threonine, L-phenylalanine, L-tryptophan, L-methionine, L-serine, L-Isoleucine, L-valine and L-leucine are produced by fermentation\u003cbr\u003e* L-alanine is derived from enzymatic synthesis from aspartic acid\u003cbr\u003e* L-tyrosine is derived from corn\u003cbr\u003e* Glycine and L-methionine are produced synthetically\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301507268,"sku":null,"price":53.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/b95a0ee4c16243caabe95460433b635cc5e4a9da87e774dba32588abad03c75a.avif?v=1781889173"},{"product_id":"athletic-pure-pack-30-packets","title":"Athletic Pure Pack 30 packets","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eVitamins and minerals in highly bioavailable forms\u003cbr\u003eVitamin C to support nitric oxide activity and immune function\u003cbr\u003eActivated B vitamins, including Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate for healthy red blood cell function\u003cbr\u003eTrace minerals, including manganese and copper, for healthy connective tissue integrity\u003cbr\u003eOmega-3 fatty acids to support healthy cytokine balance\u003cbr\u003e1, 200 mg BCAA, 375 mg creatine monohydrate, 145 mg CoQ10 and 50 mg alpha lipoic acid to support metabolic acid buffering, ATP synthesis, and muscular adaptations to resistance and endurance training\u003cbr\u003eGrape seed and superfruits help to moderate oxidative stress during training\u003cbr\u003e850 mg l-glutamine for healthy muscle preservation and immune function\u003cbr\u003eConvenient, once daily packet\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 packet daily (9 capsules), with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eSupports energy metabolism, muscle recovery and immune function in athletes and physically active individuals^‡^\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eAthletic Pure Pack is designed to promote energy metabolism 1 , muscle recovery2 , and immune function3 with a comprehensive profile of bioavailable vitamins, chelated minerals, fish oil, and other ingredients. Each pack includes activated B vitamins, including Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate, to support healthy red blood cell function.4 Vitamin C is included to support nitric oxide activity and immune function.3 L-Glutamine also supports immune function, as well as healthy muscle preservation.5 Trace minerals, including manganese and copper, support healthy connective tissue integrity.6 Omega-3 fatty acids support healthy cytokine balance.7 Creatine supports metabolic acid buffering, 8 ATP synthesis and muscular adaptations to resistance and endurance training.9 Alpha lipoic acid is an antioxidant and cofactor that supports mitochondrial function and energy metabolism.8, 11 Grape seed and superfruits contain polyphenols that may help to moderate oxidative stress during training.12\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Huskisson E, Maggini S, Ruf M. *J Int Med Res*.2007 May-Jun;35(3):277-89.\u003cbr\u003e2. Rennie MJ, MacLennan PA, Hundal HS, et al. *Metabolism*. 1989. 38(8); 47-51.\u003cbr\u003e3. NRomero SA, Ely MR, Sieck DC, et al. *Exp Physiol*.2015 Apr 1;100(4):435-49.\u003cbr\u003e4. Lamers Y, Prinz-Langenohl R, Brswig S, Pietrzik K. *Am J Clin Nutr*.2006 Jul;84(1):156-61.\u003cbr\u003e5. Song QH, Xu RM, Zhang QH, et al. *Int J Clin Pharmacol Ther*.2015 May;53(5):372-6.\u003cbr\u003e6. Institute of Medicine: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington DC: *National Academic Press* 2001.\u003cbr\u003e7. Sundrarjun T, Komindr S, Archararit N, et al. *J Int Med Res*.2004 Sep-Oct;32(5):443-54.\u003cbr\u003e8. Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, et al. *J Physiol Pharmacol*. 2009 Jun;60(2):139-43.\u003cbr\u003e9. Gualano AB, Bozza T, Lopes De Campos P, et al. *J Sports Med Phys Fitness*. 2011 Mar;51(1):82-8.\u003cbr\u003e10. Solmonson A, DeBerardinis RJ. *J Biol Chem*.2018 May 18;293(20):7522-7530.\u003cbr\u003e11. Sarmiento A, Diaz-Castro J, Pulido-Moran M, et al. *Curr Drug Metab*.2016;17(4):345-58.\u003cbr\u003e12. Shi J, Yu J, Pohorly JE, Kakuda Y. *J Med Food*.2003 Winter;6(4):291-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eTake with food.\u003cbr\u003eIf you have liver problems, consult your health professional before use.\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin).\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, particularly blood thinning medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301638340,"sku":null,"price":107.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/727bae7197e7c7275c26dbe43df9f3554f7807eef4ce6834c1651ffdd65d10c2.avif?v=1781889252"},{"product_id":"athletic-nutrients-180ct","title":"Athletic Nutrients 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports physical training and performance\u003cbr\u003e* Promotes muscle function and recovery\u003cbr\u003e* Supports healthy tendons, ligaments and joints\u003cbr\u003e* Supports antioxidant defenses\u003cbr\u003e* Activated vitamins and mineral chelates for optimal absorption\u003cbr\u003e* Offers Metafolin® L-5-MTHF, the naturally occurring universally metabolized form of folate\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, twice daily, with meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Physical training and performance support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eAthletic Nutrients is a complete, highly bioavailable multivitamin, multi-mineral and trace element supplement designed for physically active individuals and athletes. The formula combines bioavailable minerals, activated vitamins, antioxidants and pH-balanced creatine to support energy and endurance, and lessen muscle fatigue. Potassium, calcium and magnesium are included to support healthy muscle function.1 Copper, manganese, selenium and zinc help to maintain healthy tendons, ligaments and joints.2 Creatine monohydrate supports ATP regeneration and enhances work output in activities such as weightlifting and sprinting.3 NAC, alpha lipoic acid and l-carnosine support muscle recovery and comfort. In a placebo-controlled, high intensity exercise study, NAC promoted a healthy cytokine balance and supported muscle comfort.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Shils ME, Olson JA, Shike M, Ross AC. *Lippincott Williams \u0026amp; Wilkins.*. 1999. 9; 114-119.\u003cbr\u003e2. SBerger MM, Baines M, Raffoul W, et al. *Am J Clin Nutr.*. 2007 May;85(5):1293-300.\u003cbr\u003e3. Slowinska-Lisowska M, et al. *Acta Physiol Hung.* 2014 Dec;101(4):461-70.\u003cbr\u003e4. Silva LA, et al. *Int J Sport Nutr Exerc Metab.* 2008 Aug;18(4):379-88.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eTake with food.\u003cbr\u003eIf you have liver problems, consult your health professional before use.\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin).\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Mixed carotenoids:*Blakeslea trispora*\u003cbr\u003e* Lycopene: natural tomato concentrate\u003cbr\u003e* Lutein: marigold flower extract\u003cbr\u003e* Zeaxanthin: synthetic\u003cbr\u003e* Vitamin C: corn dextrose fermentation\u003cbr\u003e* Vitamin D3 : cholesterol from wool fat (lanolin)\u003cbr\u003e* Vitamin E: soybean oil\u003cbr\u003e* Vitamin K1 : synthetic\u003cbr\u003e* Vitamin B1 (thiamine HCl): synthetic\u003cbr\u003e* Vitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003e* Niacinamide and Niacin: synthetic\u003cbr\u003e* Vitamin B5 (calcium pantothenate): synthetic\u003cbr\u003e* Vitamin B6 (pyridoxal HCl and 40% pyridoxal 5' phosphate (activated B6)): synthetic\u003cbr\u003e* Vitamin B12 (methylcobalamin): corn dextrose fermentation\u003cbr\u003e* Folic acid (Metafolin®;, L-5-MTHF): synthetic\u003cbr\u003e* Biotin: synthetic\u003cbr\u003e* Minerals: naturally derived from limestone\u003cbr\u003eSources of the mineral chelates include:\u003cbr\u003e* Citrate: corn dextrose fermentation\u003cbr\u003e* Glycinate: synthetic\u003cbr\u003e* Mixed carotenoid profile typically contains 2, 000 mcg beta carotene, 112 mcg lycopene, 223 mcg lutein and 50 mcg zeaxanthin\u003cbr\u003e* Kre-Alkalyn® (pH balanced creatine) is synthetic\u003cbr\u003e* Natural coenzyme Q10 is derived from fermentation\u003cbr\u003e* Alpha ketoglutarate, alpha lipoic acid and l-carnosine are synthetic\u003cbr\u003e* N-acetyl-l-cysteine is derived from duck feather\u003cbr\u003e* PowerGrape® extract is derived from *Vitis vinifera* whole fruit and standardized to contain 85% total polyphenols\u003cbr\u003e* Superfruit antioxidant blend is from acerola, camu camu, quercetin, açai, mangosteen and green coffee concentrate\u003cbr\u003e* Decaffeinated green tea extract is derived from *Camellia sinensis* leaf and standardized to contain 70% epigallocatechin gallate (EGCG)\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301933252,"sku":null,"price":79.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/eca3b4ff99894a4e5c2e8a6eea4606213d7aba266542a212487e95a8e56d851f.avif?v=1781889316"},{"product_id":"biotin-complex-hair-skin-60ct","title":"Biotin Complex Hair \u0026 Skin 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* In a clinical trial, improvements in depth of fine lines were detected after just 3 weeks1\u003cbr\u003e* Support for hair thickness in as little as 12 weeks, according to the same study1\u003cbr\u003e* Offers clinically-researched inositol-stabilized arginine silicate and magnesium biotinate complex\u003cbr\u003e* Enhanced solubility biotin\u003cbr\u003e* Convenient once-daily dosing\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Individuals ages 18 and up\u003cbr\u003e* Healthy hair and skin support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLustriva® is a unique, patented, clinically-researched inositol-stabilized arginine silicate and magnesium biotinate complex to support hair and skin health. It contains biotin, a B vitamin that plays an important role in maintaining skin health, and silica, a mineral cofactor that plays a role in collagen integrity. In a randomized, placebo-controlled, double-blind trial of 90 healthy women (35-58 years old) with self-reported thinning hair, supplementing with 160 mg Lustriva® for 12 weeks resulted in statistically significant support for hair thickness, measured as the percentage of vellus hair (fine baby hairs), percentage of terminal hair (longer stronger hairs) and the ratio of vellus to terminal hair. Lustriva® also supported skin appearance, measured as maximal wrinkle depth, overall fine line score, and skin texture roughness. Significant improvements in depth of fine lines were detected after just 3 weeks.1 In a preclinical study, Lustriva® complex promoted hair density in mice by 23.9% on day 14 and 37.5% on day 21 compared to control.2 Hair in the active growth phase increased by 38.7% and 43% on day 14 and 21, respectively, while hair in the resting phase decreased by 26% and 31.8%. These changes were believed to be due in part to induction of the Wnt\/Beta-catenin pathway, which regulates hair follicle function.2 Lustriva® provides biotin as magnesium biotinate, which is more bioavailable than standard biotin. When magnesium biotinate was given to animals, levels of biotin in the liver increased by 47% and 27% compared to the same amount of each nutrient given separately.3, 4 Preclinical evidence also suggests that Lustriva® complex promotes biotin-dependent enzyme activity and may support skin protection.5\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kalman DS, Hewlings SJ. J Clin Exp Dermatol Res. 2021;12(1).\u003cbr\u003e2. Demir B, et al. Biol Trace Elem Res. 2022 Feb 28:1-15.\u003cbr\u003e3. Ojalvo SP, et al. Curr Dev Nutrition. 2019;3(1).\u003cbr\u003e4. Sahin K, et al. Magnes Res. 2021;34(1):9-19.\u003cbr\u003e5. Cicek D, et al. Front Pharmacol. 2021;12:657207.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eBiotin may interfere with certain blood tests. Wait at least 8 hours between biotin consumption and blood testing. Inform your health professional about all biotin-containing supplements you are taking. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eBiotin is synthetic\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302097092,"sku":null,"price":45.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/264971ddca5c9033db6fb8f3591b52ecb7137ef15c36e19202b2792f5000892f.avif?v=1781889389"},{"product_id":"ultra-b-complex-w-pqq-60ct","title":"Ultra B-Complex w\/ PQQ 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Broad-spectrum methylation, nerve, and cellular energy support\u003cbr\u003e* Enhanced support for nerve health and neuronal gene expression\u003cbr\u003e* Promotes energy production by supporting mitochondrial biogenesis\u003cbr\u003e* Features folate as Metafolin® L-5-methyltetrahydrofolate (L-5MTHF), the naturally occurring, universally metabolized form of folate, and vitamin B~12~ as a blend of activated methylcobalamin and adenosylcobalamin\u003cbr\u003e* With PQQ, alpha lipoic acid, and luteolin for enhanced antioxidant and cellular support\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-2 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Energy and longevity support\u003cbr\u003e* Mitochondrial and nerve health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eUltra B-Complex w\/PQQ combines essential B vitamins with PQQ to support mitochondrial bioenergetics and function. The B-complex vitamins, which are essential to basal mitochondrial function, serve as metabolic coenzymes and\/or methyl donors. Thiamin and niacin support healthy neuron cell longevity, neuronal membrane function and impulse conduction. L-5-MTHF, methylcobalamin and vitamin B6 support neuronal health as methylation cofactors in myelin and neurotransmitter biosynthesis.1 Adenosylcobalamin is active form of vitamin B12 in mitochondria, where it maintains cellular energy (ATP) production by acting as a cofactor or MCM (methylmalonyl CoA mutase), whose activity declines with age in animal models.2 Animal studies suggest that adenosylcobalamin enhances mitochondrial bioenergetics, maintains type IIA fast-twitch muscle fiber size in aging animals and maintains neuromuscular junction integrity.3 Preliminary data show that adenosylcobalamin also supports healthy myelination of peripheral neurons innervating muscle.3 PQQ provides B vitamin-like activity with unique antioxidant properties. PQQ supports mitochondrial, neuronal and cellular function, at least in part by activation of Nrf2 and antioxidant gene expression. PQQ may also help to maintain cytokine balance. Studies indicate significant support for cognitive function, including increased cerebral blood flow and oxygen metabolism. Preliminary research suggests that PQQ promotes mitochondrial biogenesis by targeting SIRT1 and PGC-1α.4 Alpha lipoic acid provides additional support for mitochondrial energy utilization. Alpha lipoic acid and luteolin are both antioxidants that support neuronal health.5 Research suggests luteolin also helps maintain healthy macrophage activity and gene expression in the nervous system.6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Jacobs AM, et al. *Rev Neurol Dis.* 2011;8(1-2):39-47.\u003cbr\u003e2. Pannérec A, et al. *J Cachexia Sarcopenia Muscle.* 2018 Feb;9(1):41-52.\u003cbr\u003e3. Dror DK, Allen LH. *Nutrition Reviews.*2008;66(5):250-255.\u003cbr\u003e4. Harris CB, et al. *Nutr Biochem.* 2013 Dec;24(12):2076-84.\u003cbr\u003e5. Jones W, et al. *Free Radic Biol Med.* 2002 Jul 1;33(1):83-93\u003cbr\u003e6. Asadi S, et al. *J Neuroinflammation.* 2012 May 4;9:85.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin B1 (thiamine HCl), niacinamide, niacin, vitamin B5 (calcium pantothenate), vitamin B6 (pyridoxal HCl), folic acid (Metafolin® , L-5-MTHF), biotin and alpha lipoic acid are synthetic\u003cbr\u003e* Vitamin B2 (riboflavin) and vitamin B12 (methylcobalamin) are derived from corn dextrose fermentation\u003cbr\u003e* Luteolin is derived from *Chrysanthemum indicum L* leaf\u003cbr\u003e* BioPQQ® pyrroloquinoline quinone disodium salt is manufactured in Japan using a patented natural fermentation process. It contains 2.7 mg sodium per capsule\u003cbr\u003e* Ascorbyl palmitate is produced from corn dextrose fermentation\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302129860,"sku":null,"price":90.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/929141d191e978204b5beabe242ebce8c58b0d4c03ceb3f16ec5d155f0fe9ee1.avif?v=1781889458"},{"product_id":"brain-reset-60ct","title":"Brain Reset™ 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes concentration, mental clarity, and memory with a multi-faceted blend of nutrients and herbal extracts\u003cbr\u003e* Promotes neuroimmune health by supporting cellular function, neuroprotection, and immune mediator balance\u003cbr\u003e* Unique ginkgo-phosphatidylserine sunflower phytosome complex for enhanced absorption and bioavailability\u003cbr\u003e* 400 mg lion' mane mushroom extract and 100 mg luteolin per serving\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eBrain Reset™ is designed to promote concentration and memory with multi-faceted support for healthy blood flow, immune mediator production, neuroprotection, and cognitive function. Ginkgo biloba and butcher's broom help sustain the strength and elasticity of blood vessels and capillaries, and may also promote the flow of oxygen and blood to the brain. Ginkgo biloba is included in this formula as Virtiva® ginkgo-phosphatidylserine phytosome complex. Phytosomes boost resistance to degradation in the digestive tract and promote efficient absorption across membranes for enhanced bioavailability. In a randomized, double-blind, placebo-controlled crossover study, phosphatidylserine-bound ginkgo extract enhanced secondary memory performance and significantly increased speed of memory task performance at 1, 2.5, 4 and 6 hours, compared to standard ginkgo extract or phosphatidylcholine-bound ginkgo extract.1 In another study, ginkgo extract promoted executive function in women.2 Preliminary research suggests that ginkgo may also support dopamine levels in the prefrontal cortex of the brain. Bacopa extract has over 35 years of clinical research focusing on support for memory and peak cognitive performance. In a randomized, controlled trial involving healthy adults, 320 mg of bacopa extract promoted performance on cognitively demanding tests.3 In another study, it promoted multi-tasking performance at 1 and 2 hours after administration, and supported positive mood.4 In a third trial, 90 days of supplementation with Bacopa promoted working memory performance, including spatial working memory accuracy and visual information processing accuracy.5 Riboflavin and feverfew have been studied for their ability to promote cranial comfort, with numerous randomized, double-blind, placebo-controlled trials exploring their supportive effects. Feverfew is thought to act in part by maintaining healthy cytokine, leukotriene and prostaglandin metabolism, as well as promoting healthy cranial vascular muscle function. Luteolin promotes neuronal health through antioxidant, immunomodulating, and mast cell stabilizing actions, helping to moderate the release of immune mediators. In a randomized, double-blind trial involving older men and women, daily supplementation with 3.2 grams of lion's' mane powder (equivalent to 800 mg of Lion's mane 30% polysaccharides extract) daily for 12 weeks promoted cognitive function, as assessed by the Mini mental state examination questionnaire (MMSE).6 It may also offer support for relaxation and mood. In vitro and animal research suggest that lion's mane promotes neuronal health by supporting nerve growth factor (NGF) synthesis.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kennedy DO, et al. *Hum Psychopharmacol Clin Exp.* 2007;22:199-210.\u003cbr\u003e2. Ong Lai Teik D, et al. *PLoS One.* 2016 Mar 3;11(3):e0150447.\u003cbr\u003e3. Downey LA, et al. *Phytother Res.* 2013 Sep;27(9):1407-13.\u003cbr\u003e4. Benson S, et al. *Phytother Res.* 2014 Apr;28(4):551-9.\u003cbr\u003e5. Stough C, et al. *Phytother Res.* 2008 Dec;22(12):1629-34.\u003cbr\u003e6. Saitsu Y, et al. *Biomed Res.* 2019;40(4):125-131.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302162628,"sku":null,"price":39.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/376ae3dd4c0bd5a1c1e3c4bd6a556b3eea8e26d31827b62737cf69d08246d036.avif?v=1781889536"},{"product_id":"sunbutyrate-tg-liquid-280ml","title":"SunButyrate™-TG liquid 280ml","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes gut cell function\u003cbr\u003e* Supports intestinal health and mucosal barrier function\u003cbr\u003e* Unique SunButyrate™ , butyrate-rich triglyceride oil, prevents breakdown in the upper G.I. tract and delivers butyrate directly to the intestine\u003cbr\u003e* Promotes cytokine balance in the G.I. tract, bowel motility, and abdominal comfort\u003cbr\u003e* Delivers 875 mg butyric acid per serving\u003cbr\u003e* Great-tasting blueberry vanilla flavor\u003cbr\u003e* Excipient free\u003cbr\u003e* Part of the PureGI™ product line\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 teaspoon, 1-3 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Gastrointestinal health and function\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eButyrate is one of the three most abundant shortchain fatty acids (SCFAs) produced by anaerobic bacterial fermentation of polysaccharides\/fiber in the colon, where it serves as an energy source for epithelial cells.1 Butyrate plays a major role in intestinal physiology, supporting both physical and biochemical protective barrier function, bowel motility, nutrient absorption, and immune activity of intestinal cells.2 It also promotes the proliferation, differentiation and renewal process of the colonocytes. Research suggests that SCFAs produced by intestinal bacteria activate key players in the regulation of energy metabolism in the gut as well as regulate healthy gene expression for mucin production, supporting tight-junction assembly, healthy mucous production, and a healthy intestinal barrier.3 In a four-week study comparing a standard low fiber Western diet to a high-fiber diet with high levels of resistant starch from potato and wheat bran concentrated in the hemicellulose fiber arabinoxylan, levels of butyrate, acetate and other SCFAs significantly increased, as did epithelial mucin 2 (MUC2) and the tight junction protein occludin.4 Research suggests increased efficacy of oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis.5 SCFAs also help protect epithelial cells by modulating oxidative stress and immune mediators, including prostaglandins; cytokines such as TNF-a, IL-6, IL-10; and the transcription factor NF-κB. Clinical trials indicate that butyrate supplementation supports intestinal function and promotes healthy cytokine balance in the G.I. tract.6 In a 30-day trial involving 50 subjects, 1g butyrate promoted healthy G.I. motility, abdominal comfort, and reduced bloating in 68% of subjects.7 Preliminary research suggests SCFAs could also offer support for blood vessel and blood-brain barrier integrity, as well as relaxation and satiety.8 Animal studies suggest that SCFA supplementation may moderate corticosterone response and promote the secretion of peptide YY, to inhibit gastric emptying and intestinal transit time.9 As butyrate is typically produced in the colon, oral butyrate salts have poor palatability and are easily degraded by stomach acid, preventing delivery to the colon. Novel triglyceride-form SunButyrate™ offers a light and pleasant tasting, unique triglyceride-form sunflower-based oil designed to protect butyrate from degradation in the stomach and upper G.I. tract. Studies in simulated G.I. models indicate 6-8% breakdown in the stomach compared to 70% for other forms. Butyrate is released from the triglyceride by lipases in the small intestine.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Canani RB, et. al. *World J Gastroenterol.* 2011 Mar 28;17(12):1519-28.\u003cbr\u003e2. Krokowicz L, et. al.*Int J Colorectal Dis.* 2014 Mar;29(3):387-93.\u003cbr\u003e3. Cushing K, et. al.*Clin Transl Gastroenterol.*2015 Aug 27;6:e108\u003cbr\u003e4. Hald S, et al.*PLoS One.*2016 Jul 19;11(7):e0159223.\u003cbr\u003e5. Vernia P, et al.*Dig Dis Sci.* 2000 May;45(5):976- 81.\u003cbr\u003e6. Hammer HM, et. al.*Clin Nutr.*2009 Feb;28(1):88-93.\u003cbr\u003e7. Scarpellini E, et al. *Digestive and Liver Disease Supplements 1* (2017): 19-22.\u003cbr\u003e8. Miller SJ, et. al. *Nutrition.*2005 Jun;21(6):740-8.\u003cbr\u003e9. Longo WE, et. al.*Scand J Gastroenterol.* 1991 Apr;26(4):442-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eSunButyrate is developed in a unique manufacturing process that combines tributyrin (naturally found in butter, but commercially prepared for SunButyrate from a proprietary synthetic source) and triolein (from high oleic sunflower oil)\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302195396,"sku":null,"price":42.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/75f26ab07f41876fbb35216134311bb3c603579ac8f9ad7999f6798e628c1fe7.avif?v=1781889601"},{"product_id":"hist-reset-120ct","title":"Hist Reset 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Multi-faceted support for nasal and respiratory health\u003cbr\u003e* Promotes healthy mast cell stabilization\u003cbr\u003e* Supports healthy histamine metabolism\u003cbr\u003e* 100 mg luteolin per serving\u003cbr\u003e* Includes flavonoids quercetin, luteolin, and rutin for antioxidant and immune suppor\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Individuals that experience symptoms of histamine intolerance, such as general fatigue or discomfort, occasional GI upset, skin sensitivity or flushing\u003cbr\u003e* Individuals with a polymorphism in the AOC1 gene\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eHistamine is a substance found in many foods such as meat, spinach, avocadoes, nuts, tomatoes, and chocolate, or released as part of the local immune response by immune cells, primarily mast cells, upon exposure to an immune trigger. Some individuals have difficulty breaking down histamine.1 This formula is designed to modulate mast cell and immune mediator activation, support healthy histamine metabolism, and promote respiratory and tissue health. Quercetin, luteolin, and rutin are flavonoids known to exhibit antioxidant and immune modulating activity. In vitro studies involving mast cells suggest that these compounds help to stabilize mast cells and modulate the release of immune mediators, including histamine, leukotrienes and prostaglandins.2-4 The mechanism of action is believed to be in part due to modulating extracellular signal-regulated kinases, including PKC. Animal studies suggest that these flavonoids can moderate IgE antibody's mediated response in skin.5 Bromelain (from pineapple) acts as a protease, promoting healthy levels of kinins to support tissue comfort. Research suggests that bromelain also supports healthy T cell function and cytokine production. Riboflavin, niacinamide, and molybdenum are included as cofactors for aldehyde dehydrogenase, a key enzyme in the breakdown of histamine. Preliminary research suggests that supplementation with vitamin C modulates bronchial responsiveness to histamine in sensitive subjects.6 Optimal vitamin C serum levels have been associated with lower blood histamine levels.7 NAC promotes immune and lung defense through mucolytic and antioxidant actions. It acts as a free radial scavenger by supporting glutathione production. Due to its sulfur content, NAC is able to disrupt disulfide bonds within mucus, thinning and easing its expulsion, along with the trapped particles, from the lungs.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Maintz L, Novak N. *Am J Clin Nutr*..2007 May;85(5):1185-96.\u003cbr\u003e2. Theoharides TC, et al. *Front Neurosci*.2015 Jul 3;9:225.\u003cbr\u003e3. Weng Z, et al. *PLoS One*.2012;7(3):e33805.\u003cbr\u003e4. Kimata M, et al.*Clin Exp Allergy*.2000 Apr;30(4):501-8.\u003cbr\u003e5. Park HH, et al. *Arch Pharm Res*.2008 Oct;31(10):1303-11.\u003cbr\u003e6. Bucca C, et al.*Ann Allergy*.1990 Oct;65(4):311-4.\u003cbr\u003e7. Johnston CS, et al. *J Am Coll Nutr*.1996;15:586-591.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302260932,"sku":null,"price":61.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/3cdcc09f467fd093899c2a6306cf0d907b97ad83120dfb55c787590ca8e314c5.avif?v=1781890626"},{"product_id":"hair-skin-nails-ultra-60ct","title":"Hair\/Skin\/Nails Ultra 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy hair, skin and nails\u003cbr\u003e* May help moderate the appearance of wrinkles and blemishes \u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003cbr\u003e* With Metafolin® L-5-MTHF, the predominant, naturally occurring form of folate in food\u003cbr\u003e* Contains BioCell Collagen® , a patented, hydrolyzed and denatured low molecular weight collagen\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy hair, skin and nail support^‡^\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVitamin C, zinc, copper, manganese and silica are integral cofactors for collagen and keratin synthesis, promoting skin elasticity. Optimal levels of these nutrients, as well as folate, have been associated with healthy hair, skin and nails.1, 2 Vitamin C supports skin resiliency and helps counter the effects of oxidative stress.3 Coenzyme Q10 also provides antioxidant support. Niacinamide and zinc promote immune function in the skin.4 The proanthocyanidins in grape seed extract help to stabilize collagen and elastin by moderating the proteolytic enzymes collagenase and elastase.5 Clinical studies indicate that biotin may help reinforce the keratin structure of the nails, promoting strength and thickness.6 PABA supports the appearance of healthy hair through its effects on melanin metabolism.7 BioCell Collagen® is a patented, hydrolyzed and denatured low molecular weight collagen, providing a naturally occurring matrix of hyaluronic acid (HA), chondroitin sulfate and amino acids including lysine, proline and hydroxyproline.8 These structural components support the elasticity and firmness of skin.9 Furthermore, HA attracts water, promoting hydration and moisture retention within the dermal matrix.10 Case reports have revealed that BioCell Collagen® helped moderate the appearance of wrinkles and blemishes in the skin.11\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Jin W, et al. *Guang Pu Xue Yu Guang Pu Fen Xi.*1998 Feb;18(1):91-3\u003cbr\u003e2. AraË™jo LA, et al. *An Bras Dermatol.* 2016 May-Jun;91(3):331-5.\u003cbr\u003e3. Abdollahzad H, et al. *Int J Vitam Nutr Res.* 2009 Sep;79(5-6):281-7.\u003cbr\u003e4. Fivenson DP. *Cutis.* 2006 Jan;77(1 Suppl):5-10.\u003cbr\u003e5. Maffei Facino R, et al. *Arzneimittelforschung.* 1994 May;44(5):592-601.\u003cbr\u003e6. Hochman LG, et al. *Cutis.* 1993 Apr;51(4):303-5.\u003cbr\u003e7. Zarafonetis CJD. *J Invest Dermatol* 1950;15; 399-401.\u003cbr\u003e8. BioCell Collagen, LLC. 2014. White Paper.\u003cbr\u003e9. Inoue N, et al. *J Sci Food Agric.* 2016 Sep;96(12):4077- 81.\u003cbr\u003e10. Chinatsu K, et al. *Nutr J.* 2014; 13: 70.\u003cbr\u003e11. Schwartz SR, et al. *Clin Interv Aging.*2012;7:267-73.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eBiotin may interfere with certain blood tests. Wait at least 8 hours between biotin consumption and blood testing. Inform your health professional about all biotin-containing supplements you are taking. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin C is derived from corn dextrose fermentation.\u003cbr\u003e* Niacinamide, folate (as Metafolin^®^ , L-5-MTHF), biotin.\u003cbr\u003e* PABA (para-aminobenzoic acid) and glycinate are synthetic.\u003cbr\u003e* Zinc, copper and manganese are derived from elemental ore.\u003cbr\u003e* Citrate is derived from corn dextrose fermentation.\u003cbr\u003e* Silica is derived from *Bambusa vulgaris* (bamboo) stem.\u003cbr\u003e* Hydrolyzed collagen complex is derived from chicken sternal cartilage and standardized to typically provide 60% hydrolyzed collagen, 20% chondroitin sulfate and 10% hyaluronic acid.\u003cbr\u003e* Grape seed extract is derived from *Vitis vinifera* and standardized to contain 92% polyphenols.\u003cbr\u003e* CoQ10 is obtained naturally from fermentation.\u003cbr\u003e* Maltodextrin and starch are derived from corn and potato\u003cbr\u003e* Citrus bioflavonoids are derived from orange peel.\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil.\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302293700,"sku":null,"price":51.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/81e6363b4ae2317b1c6127970260fbda84c4da9345e454b7a8a3a50c1686581c.avif?v=1781890698"},{"product_id":"inositol-complex-60ct","title":"Inositol Complex 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes healthy glucose homeostasis and insulin function\u003cbr\u003e* Supports healthy ovarian function\u003cbr\u003e* Supports emotional wellness\u003cbr\u003e* Contains 150 mg of D-chiro inositol per capsule\u003cbr\u003e* Offers clinically researched 3.6:1 ratio myo- inositol to D-chiro inositol\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy ovarian function\u003cbr\u003e* Healthy glycemic response\u003cbr\u003e* Emotional wellness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eInositol is a component of the B-complex family. The predominant form of inositol in the body and central nervous system is myo-inositol. Myo-inositol plays an important role in cell membrane formation and serves as part of the phosphatidylinositol second messenger system, supporting serotonin, norepinephrine and cholinergic receptor function.1 Optimal levels of inositol have been associated with positive mood, emotional wellness and help lessen occasional nervous tension.2 D-chiro inositol is another isomer with distinct functions in the body from myo-inositol. Both forms act as second messengers to support healthy insulin signaling, however, D-chiro inositol also helps promote the cellular response to insulin.3 D-chiro inositol also plays a role in maintaining healthy androgen metabolism.4 The combination of myo-inositol and D-chiro inositol helps to support healthy ovarian function and reproductive system function. Studies suggest that the ratio of myo-inositol and D-chiro inositol influences clinical effects. The ratio varies considerably across different tissues, ranging from 2:1 in the liver, 200:1 in the brain and heart, 100:1 in the follicular fluid, and 40:1 in the blood.2 Studies have utilized ratios ranging from 0.4:1 to 104:1 of D- chiro inositol:myo-inositol.3 A 2019 comparison study suggests that a 3.6:1 ratio of myo-inositol:D- chiro inositol supports reproductive function when compared to an alternate (40:1) ratio. Twelve weeks of supplementation with 550 mg myo-inositol and 150 mg D-chiro inositol twice daily (3.6:1 ratio) was found to offer support for oocyte quality and healthy pregnancy.5 Two additional studies indicate that supplementation with a 3.6:1 myo-inositol:D-chiro inositol ratio for 6 months supported healthy menstrual regularity, luteinizing hormone\/follicle- stimulating hormone (LH\/FSH) ratios and glucose homeostasis.6, 7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Nagata E. Clin Calcium. 2015 Feb;25(2):227-38.\u003cbr\u003e2. Gambioli R, et al. Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):438-446.\u003cbr\u003e3. Monastra G, et al. Front Endocrinol (Lausanne). 2021 Apr 6;12:660381.\u003cbr\u003e4. Gambioli R, et al. Biomedicines. 2021 Oct 2;9(10):1378.\u003cbr\u003e5. Mendoza N, et al. Gynecol Endocrinol. 2019 Aug;35(8):695-700.\u003cbr\u003e6. Kachhawa G, et al. Int J Gynaecol Obstet. 2021 Oct 8.\u003cbr\u003e7. Bahadur A, et al. Cureus. 2021 Jun 7;13(6):e15510.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Inositol is derived from corn (*Zea mays L.*) fruit\u003cbr\u003e* D-Chiro inositol is derived from carob (*Ceratonia siliquia L.*) pods\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302359236,"sku":null,"price":55.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/c78a4e4a0b6a5af57d6998f4198e4bc04c245e5acc42b0d8c02b3a2294228160_1.avif?v=1781890796"},{"product_id":"liposomal-vitamin-c-liquid-120ml","title":"Liposomal Vitamin C liquid 120ml","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Protects from free radicals to support tissue health and the body' defense system\u003cbr\u003e* Utilizes soy-free, non-GMO sunflower liposomes to help protect the vitamin C\u003cbr\u003e* Promotes healthy mast cell function and lymphocyte formation\u003cbr\u003e* Unique liposomal delivery form for enhanced absorption\u003cbr\u003e* Includes soy-free, non-GMO liposomes from sunflower\u003cbr\u003e* Made with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 teaspoon daily, or as directed by a health professional. Hold in mouth for 30 seconds before swallowing. Take on an empty stomach, at least 10 minutes before meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Immune support\u003cbr\u003e* Antioxidant defense\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLiposomal Vitamin C liquid offers the antioxidant vitamin C in an enhanced absorption liposomal form to target cellular health and function, as well as immune defense.1, 2 This liposomal liquid delivery system utilizes phospholipids from non-GMO sunflower oil and tight manufacturing control to ensure vitamin C encapsulation for optimal performance.3 The controlled processing procedure results in very small, higher-stable, spherical liposomes. These small-sized liposomes allow for increased diffusion across mucus membranes and absorption.4, 5\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Moyad MA et al. Adv Ther. 2008 Oct;25(10):995-1009.\u003cbr\u003e2. Kennes B, et al. Gerontology. 1983;29(5):305-10.\u003cbr\u003e3. Keller BC. Trends Food Sci \u0026amp; Tech. 2001; 12: 25-31.\u003cbr\u003e4. Shade CW. Integr Med (Encinitas). 2016 Mar; 15(1): 33â€\"36.\u003cbr\u003e5. Gopi S\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eet al. J Liposome Res. 2021 Dec;31(4):356-364.,If you are pregnant or lactating\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003ehave any health condition or are taking any medication\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003econsult your health professional before use.,Store in a cool\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302621380,"sku":null,"price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/cfe9846160e9b43e98e0e0c0ccda207a5465130a4fa724575aaed1371f54dddd.avif?v=1781890866"},{"product_id":"l-glutamine-850-mg-90ct","title":"l-Glutamine 850 mg 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports gastrointestinal tract\u003cbr\u003e* Helps maintain intestinal integrity\u003cbr\u003e* Made with hypoallergenic, vegan ingredients\u003cbr\u003e* Promotes tissue repair from metabolic stress\u003cbr\u003e* Helps maintain healthy intestinal integrity by enhancing the intestine's protective mucosal lining\u003cbr\u003e* May provide support for immune function and exercise recovery\u003cbr\u003e* Available in convenient capsule and powder forms\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e500 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003e850 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003ePowder\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 heaping scoop mixed with water or juice, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Gastrointestinal tract integrity support\u003cbr\u003e* Tissue repair and immune system health\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003el-Glutamine is the most abundant amino acid in the body's In times of metabolic stress, glutamine is utilized by the body'sfor tissue repair and gastrointestinal tract support.1, 2 Glutamine plays a large role in maintaining healthy intestinal integrity by enhancing the intestine?s protective mucosal lining.3 In addition, glutamine is important in the preservation of muscle mass.4 Its effects on immune function may support post-exercise recovery.5, 6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Sasaki E, et al. Luminescence. 2013 Jul-Aug;28(4):442-9.\u003cbr\u003e2. Song QH, et al. Int J Clin Pharmacol Ther. 2015 May;53(5):372-6.\u003cbr\u003e3. Lima AA, et al. Clinics (Sao Paulo). 2014;69(4):225-33.\u003cbr\u003e4. Rennie MJ, et al. Metabolism. 1989. 38(8); 47-51.\u003cbr\u003e5. Song QH, et al. Int J Clin Pharmacol Ther. 2015 May;53(5):372-6.\u003cbr\u003e6. Hiscock N, et al. J Appl Physiol (1985). 2003 Jul;95(1):145-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult yourhealth professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003el-Glutamine is derived from corn dextrose fermentation\u003cbr\u003eVitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302654148,"sku":null,"price":29.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/bf3ac3398d22069b9f74bec6fa333b3072a1e8eb0723d54c110983067dd0e55a_1.avif?v=1781890948"},{"product_id":"l-glutamine-850-mg-250ct","title":"l-Glutamine 850 mg 250ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports gastrointestinal tract\u003cbr\u003e* Helps maintain intestinal integrity\u003cbr\u003e* Made with hypoallergenic, vegan ingredients\u003cbr\u003e* Promotes tissue repair from metabolic stress\u003cbr\u003e* Helps maintain healthy intestinal integrity by enhancing the intestine's protective mucosal lining^‡^\u003cbr\u003e* May provide support for immune function and exercise recovery\u003cbr\u003e* Available in convenient capsule and powder forms\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e500 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003e850 mg capsules\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003ePowder\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 heaping scoop mixed with water or juice, 1-3 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Gastrointestinal tract integrity support\u003cbr\u003e* Tissue repair and immune system health\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003el-Glutamine is the most abundant amino acid in the body's In times of metabolic stress, glutamine is utilized by the body'sfor tissue repair and gastrointestinal tract support.1, 2 Glutamine plays a large role in maintaining healthy intestinal integrity by enhancing the intestine?s protective mucosal lining.3 In addition, glutamine is important in the preservation of muscle mass.4 Its effects on immune function may support post-exercise recovery.5, 6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Sasaki E, et al. Luminescence. 2013 Jul-Aug;28(4):442-9.\u003cbr\u003e2. Song QH, et al. Int J Clin Pharmacol Ther. 2015 May;53(5):372-6.\u003cbr\u003e3. Lima AA, et al. Clinics (Sao Paulo). 2014;69(4):225-33.\u003cbr\u003e4. Rennie MJ, et al. Metabolism. 1989. 38(8); 47-51.\u003cbr\u003e5. Song QH, et al. Int J Clin Pharmacol Ther. 2015 May;53(5):372-6.\u003cbr\u003e6. Hiscock N, et al. J Appl Physiol (1985). 2003 Jul;95(1):145-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult yourhealth professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003el-Glutamine is derived from corn dextrose fermentation\u003cbr\u003eVitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302719684,"sku":null,"price":66.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/bf3ac3398d22069b9f74bec6fa333b3072a1e8eb0723d54c110983067dd0e55a_2.avif?v=1781891010"},{"product_id":"liposomal-glutathione-liquid-50ml","title":"Liposomal Glutathione liquid 50ml","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Protects from free radicals to support tissue health\u003cbr\u003e* Supports liver health and detoxification\u003cbr\u003e* Plays a critical role in cellular function, including protein synthesis, enzyme function, and cell maturation\u003cbr\u003e* Enhanced liposomal liquid delivery system\u003cbr\u003e* Pleasant-tasting, lemon-mint flavor\u003cbr\u003e* 100 mg of glutathione per serving\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 pumps by mouth, 2 times daily, or as directed by a health professional. Hold inmouth 30 seconds before swallowing. Take on an empty stomach, at least 10 minutes before meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Antioxidant defense\u003cbr\u003e* Detoxification support\u003cbr\u003e* Daily wellness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLiposomal Glutathione liquid offers the antioxidant glutathione in an enhanced-absorption liposomal form to target cellular health and function.1 Glutathione is a large molecule composed of glutamine, cysteine and glycine. It is found in virtually every cell of the body and plays a critical role in protein synthesis, enzyme function and transport, and cell maturation. It is also one of the main endogenous antioxidants, acting to recycle other antioxidants and protect the body from free radicals.2 Optimal levels of glutathione have been associated with physical and mental health, 3 and the liposomal form helps to protect the glutathione bonds from degradation that can occur in digestion. This liposomal liquid delivery system utilizes phosphatidylcholine from non-GMO sunflower oil and tight manufacturing control to ensure glutathione encapsulation for optimal performance. The controlled processing procedure results in very small, highly stable spherical liposomes. These small liposomes allow for increased absorption and diffusion across mucus membranes.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Sinha R, et al. *Eur J Clin Nutr.* 2018 Jan;72(1):105-111.\u003cbr\u003e2. Richie JP Jr, et. al. *Eur J Nutr.* 2015 Mar;54(2):251-63.\u003cbr\u003e3. Lang CA, et. al. *J Lab Clin Med.* 2002 Dec;140(6):413-7.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eKeep refrigerated.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Glutathione source is microbial fermentation\u003cbr\u003e* Phospholipids source is sunflower\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302752452,"sku":null,"price":60.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/78995d1bf081d6950e3db888fb652bddbd0c8771ee323aa571645b03f09b5907.avif?v=1781891073"},{"product_id":"longevity-nutrients-120ct","title":"Longevity Nutrients 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Provides support for cognitive function and cardiovascular health\u003cbr\u003e* Supports cellular, bone and heart health\u003cbr\u003e* Promotes healthy brain cell function and blood vessel function\u003cbr\u003e* Offers advanced macular and retinal protection\u003cbr\u003e* Easy-to-swallow capsule size\u003cbr\u003e* Convenient 4-capsule daily dose\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 2 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Nutritional support for men and women over 40\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThe formula combines essential vitamins, mineralsand antioxidants to support optimal health.1 Vitamins K1 , K2 and vitamin D3 support cellular, bone and heart health.2, 3 Enhanced levels of ChromeMate® chromium polynicotinate and biotin for metabolic support.4 Promotes cellular energy production with adenosylcobalamin and CoQ10.5 Folic acid provided as Metafolin® , 5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring universally metabolized form of folate.6 Adenosylcobalamin is the form of vitamin B12 active in mitochondria, boosting mitochondrial energy (ATP) production. Animal studies suggest it specifically enhances mitochondrial bioenergetics, promotes type IIA fast twitch muscle fiber size during aging and stabilizes neuro-muscular junctions.7 Cognizin® citicoline promotes choline and phospholipid composition in the brain, essential for neuronal communication and protection, as well as daily mental task performance.8 Provides targeted support for healthy brain cell function with Curcumin C3 Complex.9 Maintains healthy blood vessel function with polyphenols from pomegranate and grape seed extract.10, 11 Offers advanced macular and retinal protection with lutein, zeaxanthin and synergistic cofactors vitamin C, vitamin E, zinc and carotenoids.12\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Girodon F, et al. *. J Am Coll Nutr.* 1997 Aug;16(4):357-65.\u003cbr\u003e2. Je SH, et al. *J Korean Med Sci.* 2011 Aug;26(8):1093-8.\u003cbr\u003e3. Arnson Y, et al.*Clin Rev Allergy Immunol*. 2013 Oct;45(2):236-47.\u003cbr\u003e4. Rabinovitz H, et al. *Int J Vitam Nutr Res*. 2004 May;74(3):178-82.\u003cbr\u003e5. Zheng A, et al. *J Nutr Sci Vitaminol (Tokyo)*. 2008 Aug;54(4):286-90.\u003cbr\u003e6. Lamers Y, et al. *Am J Clin Nutr.*. 2006 Jul;84(1):156-61.\u003cbr\u003e7. Quadros EV. *Br J Haematol.*. 2010 Jan;148(2):195-204.\u003cbr\u003e8. McGlade E, et al. *Food Nutr Sciences*, 2012, 3, 769-73.\u003cbr\u003e9. Zhang L, et al. *J Alzheimers Dis*. 2006 Sep;10(1):1-7.\u003cbr\u003e10. Goyal R, et al.*Eur J Biomed Pharm Sci*. 3, 662?667 (2016).\u003cbr\u003e11. Park E, et al. *Br J Nutr.* 2016 Jan;115(2):226-38.\u003cbr\u003e12. Beatty S, et al. *Ophthalmology*. 2013 Mar;120(3):600-6.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Mixed carotenoids: *Blakeslea trispora*\u003cbr\u003e* Lycopene: natural tomato concentrate\u003cbr\u003e* Lutein: marigold flower extract\u003cbr\u003e* Zeaxanthin: synthetic\u003cbr\u003e* Vitamin C: corn dextrose fermentation\u003cbr\u003e* Vitamin D3 : cholesterol from wool fat (lanolin)\u003cbr\u003e* Vitamin E: soybean oil\u003cbr\u003e* Vitamin K1 : synthetic\u003cbr\u003e* Vitamin B1 (thiamine HCl): synthetic\u003cbr\u003e* Vitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003e* Niacinamide and Niacin: synthetic\u003cbr\u003e* Vitamin B5 (calcium pantothenate): synthetic\u003cbr\u003e* Vitamin B6 (pyridoxal HCl): synthetic\u003cbr\u003e* Vitamin B12 (methylcobalamin): corn dextrose fermentation\u003cbr\u003e* Folic acid (Metafolin® , L-5-MTHF): synthetic\u003cbr\u003e* Biotin: synthetic\u003cbr\u003e* Alpha lipoic acid: synthetic\u003cbr\u003e* Minerals: naturally derived from limestoneSources of the mineral chelates include:\u003cbr\u003e* Citrate: corn dextrose fermentation\u003cbr\u003e* Glycinate: synthetic\u003cbr\u003e* Mixed carotenoid profile typically contains 4, 500 mcg beta carotene, 125 mcg lycopene, 250 mcg lutein and 50 mcg zeaxanthin\u003cbr\u003e* Turmeric extract is derived from *Curcuma longa* root and standardized to contain 95% curcuminoids\u003cbr\u003e* Grape seed extract is derived from *Vitis vinifera* seed and standardized to contain 92% polyphenols\u003cbr\u003e* Pomegranate extract is derived from *Punica granatum L.* whole fruit and standardized to contain 40% punicosides\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302785220,"sku":null,"price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/1f8013f6c4066d50024005bce93fe77e8cf17543c132674f5f1075d012af89ad_2.avif?v=1781891176"},{"product_id":"longevity-nutrients-240ct","title":"Longevity Nutrients 240ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Provides support for cognitive function and cardiovascular health\u003cbr\u003e* Supports cellular, bone and heart health\u003cbr\u003e* Promotes healthy brain cell function and blood vessel function\u003cbr\u003e* Offers advanced macular and retinal protection\u003cbr\u003e* Easy-to-swallow capsule size\u003cbr\u003e* Convenient 4-capsule daily dose\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 2 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Nutritional support for men and women over 40\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThe formula combines essential vitamins, mineralsand antioxidants to support optimal health.1 Vitamins K1 , K2 and vitamin D3 support cellular, bone and heart health.2, 3 Enhanced levels of ChromeMate® chromium polynicotinate and biotin for metabolic support.4 Promotes cellular energy production with adenosylcobalamin and CoQ10.5 Folic acid provided as Metafolin® , 5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring universally metabolized form of folate.6 Adenosylcobalamin is the form of vitamin B12 active in mitochondria, boosting mitochondrial energy (ATP) production. Animal studies suggest it specifically enhances mitochondrial bioenergetics, promotes type IIA fast twitch muscle fiber size during aging and stabilizes neuro-muscular junctions.7 Cognizin® citicoline promotes choline and phospholipid composition in the brain, essential for neuronal communication and protection, as well as daily mental task performance.8 Provides targeted support for healthy brain cell function with Curcumin C3 Complex.9 Maintains healthy blood vessel function with polyphenols from pomegranate and grape seed extract.10, 11 Offers advanced macular and retinal protection with lutein, zeaxanthin and synergistic cofactors vitamin C, vitamin E, zinc and carotenoids.12\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Girodon F, et al. *. J Am Coll Nutr.* 1997 Aug;16(4):357-65.\u003cbr\u003e2. Je SH, et al. *J Korean Med Sci.* 2011 Aug;26(8):1093-8.\u003cbr\u003e3. Arnson Y, et al.*Clin Rev Allergy Immunol*. 2013 Oct;45(2):236-47.\u003cbr\u003e4. Rabinovitz H, et al. *Int J Vitam Nutr Res*. 2004 May;74(3):178-82.\u003cbr\u003e5. Zheng A, et al. *J Nutr Sci Vitaminol (Tokyo)*. 2008 Aug;54(4):286-90.\u003cbr\u003e6. Lamers Y, et al. *Am J Clin Nutr.*. 2006 Jul;84(1):156-61.\u003cbr\u003e7. Quadros EV. *Br J Haematol.*. 2010 Jan;148(2):195-204.\u003cbr\u003e8. McGlade E, et al. *Food Nutr Sciences*, 2012, 3, 769-73.\u003cbr\u003e9. Zhang L, et al. *J Alzheimers Dis*. 2006 Sep;10(1):1-7.\u003cbr\u003e10. Goyal R, et al.*Eur J Biomed Pharm Sci*. 3, 662?667 (2016).\u003cbr\u003e11. Park E, et al. *Br J Nutr.* 2016 Jan;115(2):226-38.\u003cbr\u003e12. Beatty S, et al. *Ophthalmology*. 2013 Mar;120(3):600-6.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Mixed carotenoids: *Blakeslea trispora*\u003cbr\u003e* Lycopene: natural tomato concentrate\u003cbr\u003e* Lutein: marigold flower extract\u003cbr\u003e* Zeaxanthin: synthetic\u003cbr\u003e* Vitamin C: corn dextrose fermentation\u003cbr\u003e* Vitamin D3 : cholesterol from wool fat (lanolin)\u003cbr\u003e* Vitamin E: soybean oil\u003cbr\u003e* Vitamin K1 : synthetic\u003cbr\u003e* Vitamin B1 (thiamine HCl): synthetic\u003cbr\u003e* Vitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003e* Niacinamide and Niacin: synthetic\u003cbr\u003e* Vitamin B5 (calcium pantothenate): synthetic\u003cbr\u003e* Vitamin B6 (pyridoxal HCl): synthetic\u003cbr\u003e* Vitamin B12 (methylcobalamin): corn dextrose fermentation\u003cbr\u003e* Folic acid (Metafolin® , L-5-MTHF): synthetic\u003cbr\u003e* Biotin: synthetic\u003cbr\u003e* Alpha lipoic acid: synthetic\u003cbr\u003e* Minerals: naturally derived from limestoneSources of the mineral chelates include:\u003cbr\u003e* Citrate: corn dextrose fermentation\u003cbr\u003e* Glycinate: synthetic\u003cbr\u003e* Mixed carotenoid profile typically contains 4, 500 mcg beta carotene, 125 mcg lycopene, 250 mcg lutein and 50 mcg zeaxanthin\u003cbr\u003e* Turmeric extract is derived from *Curcuma longa* root and standardized to contain 95% curcuminoids\u003cbr\u003e* Grape seed extract is derived from *Vitis vinifera* seed and standardized to contain 92% polyphenols\u003cbr\u003e* Pomegranate extract is derived from *Punica granatum L.* whole fruit and standardized to contain 40% punicosides\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302817988,"sku":null,"price":123.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/1f8013f6c4066d50024005bce93fe77e8cf17543c132674f5f1075d012af89ad_3.avif?v=1781891243"},{"product_id":"lithium-orotate-1-mg-90ct","title":"Lithium (orotate) 1 mg 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy mood, memory and behavior\u003cbr\u003e* Supports neurotransmitter activity\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003e* Part of the PureSYNAPSE™ product line\u003cbr\u003e* Made with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional wellness and mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLithium (orotate) 1 mg provides the nutritionally essential trace element lithium Lithium is an essential micronutrient with some chemical properties similar to calcium and magnesium. It is present in all organs and tissues in the body. Lithium has a long history of clinical use for supporting healthy mood and behavior, possibly through dopamine- and serotonin- mediated mechanisms.1-3 Lithium supports neurotransmitter systems and signaling cascades involved in brain health and behavior.1, 3 Several studies suggest that lithium supports memory and mood.1, 4, 5 A 12-month, randomized, double-blind trial involving 45 individuals suggests that low-dose lithium supplementation promotes cognitive performance.6 In cultured neurons, lithiumenhanced gene expression of glutathione-S-transferase (GST), a natural detoxification enzyme with neuroprotective functions.7 Lithium also has been shown to promote healthy brain-derived neurotrophic factor (BDNF) levels in animal models and humans.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Szklarska D, Rzymski P. Biol Trace Elem Res 189, 18-27 (2019).\u003cbr\u003e2. Beaulieu JM, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104.\u003cbr\u003e3. Schrauzer GN, et al. Biol Trace Elem Res. 1994 Jan;40(1):89-101.\u003cbr\u003e4. Nunes MA, et al. Curr Alzheimer Res. 2013 Jan;10(1):104-7.\u003cbr\u003e5. Forlenza OV, et al. Br J Psychiatry. 2011 May;198(5):351-6.\u003cbr\u003e6. Straten G. Curr Alzheimer Res. 2011 Dec;8(8):853-9.\u003cbr\u003e7. Shao L, et al. Neuroscience. 2008 Jan 24;151(2):518-24.\u003cbr\u003e8. Leyhe T, et al. J Alzheimers Dis. 2009;16(3):649-56.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Lithium is mined and refined\u003cbr\u003e* Orotate and N-acetyl-l-cysteine are synthetically derived\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302850756,"sku":null,"price":17.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/a820b6161929e39d19507e512d737508d03ea36b896d60f067faae6b73b31de4.avif?v=1781891322"},{"product_id":"liquinutrients-230-ml-7-8fl-oz","title":"LiquiNutrients 230 ml 7.8fl oz","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Activated vitamins and chelated minerals for optimal absorption\u003cbr\u003e* Supports daily wellness\u003cbr\u003e* Liquid multivitamin\/mineral complex enhanced with organic fruits and vegetables\u003cbr\u003e* Made without added sugar, fructose or artificial flavors and sweeteners\u003cbr\u003e* Convenient, great-tasting liquid formula for easy dispensing\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003cbr\u003e* Made with hypoallergenic, vegan ingredients\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 teaspoons daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Adults and children over 4\u003cbr\u003e* Daily wellness support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLiquiNutrients provides an extensive blend of vitamins, including vegan vitamin D3 , and chelated minerals for optimal absorption1 This formula also provides natural beta carotene, lutein, organic berries and vegetables to support daily wellness.2-4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Lindberg JS, et al.*J Am Coll Nutr*.1990 Feb;9(1):48-55\u003cbr\u003e2. Hickenbottom SJ, et al. *Am J Clin Nutr*. 2002 May;75(5):900-7.\u003cbr\u003e3. Renzi-Hammond LM, etal.*Nutrients. 2017 Nov 14;9(11):1246.*\u003cbr\u003e4. *Kawashima A, et al. , em\u0026gt;Asia Pac J Clin Nutr*. 2007;16(3):411-21.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin C: corn dextrose fermentation\u003cbr\u003e* Vitamin D3 (cholecalciferol): from lichen\u003cbr\u003e* Vitamin E: soybean oil\u003cbr\u003e* Vitamin B1 (thiamine HCl): synthetic\u003cbr\u003e* Vitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003e* Niacinamide and Niacin: synthetic\u003cbr\u003e* Vitamin B5 (calcium pantothenate): synthetic\u003cbr\u003e* Vitamin B6 (pyridoxal HCl): synthetic\u003cbr\u003e* Folic acid: synthetic\u003cbr\u003e* Biotin: synthetic\u003cbr\u003e* Minerals: naturally derived from lime of rock\u003cbr\u003e* Beta carotene: D. salina (algae)\u003cbr\u003e* Lutein: marigold\u003cbr\u003e* Aspartate: synthetic\u003cbr\u003e* Citrate: corn dextrose fermentation\u003cbr\u003e* Glycinate: synthetic\u003cbr\u003e* Gluconate: corn dextrose fermentation\u003cbr\u003e* Natural vegetable glycerin is derived from coconut, palm and palm kernel oil\u003cbr\u003e* Natural mango and orange flavors are derived from the fruits\u003cbr\u003e* Citric acid is derived from corn dextrose fermentation\u003cbr\u003e* Maltodextrin is derived from corn\u003cbr\u003e* Cranberry juice concentrate is derived from the whole fruit and includes the fiber and seed oil\u003cbr\u003e* Carrot juice concentrate is derived from organic *Daucus carota* root\u003cbr\u003e* Tomato juice concentrate is derived from organic *Lycopersicon esculentum* fruit\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302883524,"sku":null,"price":64.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/8c9bb816f79ba4ab3a6a408544b430fa3ba2f0fb4143770e917e0e2a0bbdfb7c.avif?v=1781891384"},{"product_id":"liposomal-vitamin-c-120ct","title":"Liposomal Vitamin C 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003ePromotes healthy immune function\u003cbr\u003eSupports cellular health\u003cbr\u003eAges 9+\u003cbr\u003eEasy to absorb, enhanced-retention form of vitamin C\u003cbr\u003eFormulated with clinically studied PureWay-C®\u003cbr\u003eStructurally validated liposomes that are small and highly stable for optimal absorption across membranes\u003cbr\u003eMade with hypoallergenic, vegan ingredients\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eImmune support\u003cbr\u003eAntioxidant defense\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVitamin C is a water-soluble nutrient that cannot freely cross the lipid membranes in the gastrointestinal tract, which limits its absorption.1 Uptake of this nutrient requires carrier proteins, which escort vitamin C across the intestinal membranes to reach the bloodstream. These carriers have a low capacity and are easily saturated, especially at higher doses of vitamin C. This limits the amount of this nutrient that reaches organs and tissues, including the cells of the immune system.2 In contrast, liposomes can freely diffuse across membranes in the GI tract.3, 4 Liposomal Vitamin C provides an enhanced-absorption form that does not require a carrier system. It contains PureWay-C®, a clinically studied form of vitamin C that combines ascorbic acid with natural lipid metabolites and citrus bioflavonoids.5, 6 This enhanced vitamin C is loaded into small-sized, spherical, highly-stable liposomes, which are verified by electron microscopy to ensure the presence of intact, authentic structures. Liposomes can be absorbed directly across mucus membranes in the gastrointestinal tract, supporting enhanced bioavailability.7 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Subramanian VS, Srinivasan P, Wildman AJ, et al. Am J Physiol Gastrointest Liver Physiol. 2017 Apr 1;312(4):G340-G347.\u003cbr\u003e2. Combs GF, McClung JP. In: The Vitamins (6th ed.) 2022.\u003cbr\u003e3. Nsairat H, Khater D, Sayed U, et al. Heliyon. 2022 May 13;8(5):e09394.\u003cbr\u003e4. Shade CW. Integr Med (Encinitas). 2016 Mar;15(1):33-6.\u003cbr\u003e5. Weeks BS, Perez PP. Med Sci Monit. 2007 Oct;13(10):BR205-10.\u003cbr\u003e6. Pancorbo D, Vazquez C, Fletcher MA. Med Sci Monit. 2008 Nov;14(11):CR547-51.\u003cbr\u003e7. Gopi S, et al. J Liposome Res. 2021 Dec;31(4):356-364\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003ePureway-C® is manufactured in a proprietary process from L-Ascorbic acid, citrus bioflavonoids (from Citrus Aurantium), fatty acids (from rice bran wax), and phospholipids (from sunflower lecithin)\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302916292,"sku":null,"price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dd6598ebea6b33e085f9c5f99d461b779faf8d8283b0235b956e23d8108e9ea8.avif?v=1781891445"},{"product_id":"mitochondria-atp-120ct","title":"Mitochondria-ATP 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy mitochondrial function\u003cbr\u003e* Enhances the production of ATP\u003cbr\u003e* Provides antioxidant support\u003cbr\u003e* Offers a blend of nutrient cofactors to support mitochondrial function\u003cbr\u003e* Now with nicotinamide riboside chloride (NR) to support NAD+ and cellular function\u003cbr\u003e* Includes acetyl-l-carnitine and creatine to support ATP synthesis\u003cbr\u003e* Contains a blend of antioxidants to support cellular heath\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 2 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Mitochondrial health and cellular energy support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eCoQ10 is a component of the mitochondria and plays a key role in the synthesis of ATP. B vitamins are important cofactors needed to fuel the Krebs cycle, while optimal serum levels of magnesium are associated with healthy mitochondrial metabolism and nutrient transport.1 Nicotinamide riboside chloride (NR) is precursor of nicotinamide adenine dinucleotide (NAD+), a key driver of cellular energy production.2-7 Some evidence suggests that NAD+ declines with age in humans.6, 8 NAD+ activates SIRT1, an epigenetic switch that regulates metabolism, mitochondrial biogenesis, cellular energy production and cellular longevity.4-7 Higher NAD+ levels are associated with healthy mitochondrial function.5, 6 Acetyl-l-carnitine provides carnitine to transport long chain fatty acids into the mitochondria for energy as well as an acetyl group for the synthesis of the Krebs cycle precursor acetyl-CoA.7 Highly pure creatine monohydrate helps enhance the production of the ATP by adding a phosphate group during its formation.8 This formula provides antioxidant support with vitamins C and E, as well as resveratrol, alpha lipoic acid and N-acetyl-l-cysteine. Antioxidants neutralize the free radicals generated during energy production in the mitochondria. In a double-blind, placebo-controlled, crossover study, the combination of creatine, CoQ10 and alpha lipoic acid supported energy production and antioxidant status within the mitochondria.9 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Institute of Medicine. Washington (DC): National Academies Press (US); 1998. pg 27.\u003cbr\u003e2. Conze D, Brenner C, Kruger CL. Sci Rep. 2019 Jul 5;9(1):9772.\u003cbr\u003e3. Trammell SA, Schmidt MS, Weidemann BJ, et al. Nat Commun. 2016 Oct 10;7:12948.\u003cbr\u003e4. Covarrubias AJ, Perrone R, Grozio A, Verdin E. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.\u003cbr\u003e5. Janssens GE, Grevendonk L, Perez RZ, et al. Nat Aging. 2022 Mar;2(3):254-263.\u003cbr\u003e6. Chu X, Raju RP. Metabolism. 2022 Jan;126:154923.\u003cbr\u003e7. Clement J, et al. Rejuvenation Res. 2019 Apr;22(2):121-130.\u003cbr\u003e8. Vandenberghe K, Goris M, Van Hecke P, et al. J Appl Physiol (1985). 1997 Dec;83(6):2055-63.\u003cbr\u003e9. Rodriguez MC, et al. Muscle Nerve. 2007 Feb;35(2):235-42.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin C and riboflavin (B2) are derived from corn dextrose fermentation\u003cbr\u003e* Vitamin E (d-alpha tocopherol succinate) is derived from soybean oil, processed and purified to contain no soy protein or isoflavones\u003cbr\u003e* Magnesium is derived from earthen ore\u003cbr\u003e* Coenzyme Q10 is produced by microbial (yeast) fermentation. There is no residual yeast in the final product\u003cbr\u003e* Resveratrol extract is derived from *Polygonum cuspidatum* root and standardized to contain 50% trans resveratrol\u003cbr\u003e* Thiamin, Nicotinamide Riboside, Creatine Monohydrate, Acetyl-l-carnitine, NAC and Alpha Lipoic Acid are synthetic\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302949060,"sku":null,"price":82.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/8eebd08707a3dcf51a0e1ba3576daf60e00b48a5f8890466a6582fd9989b0b59.avif?v=1781891514"},{"product_id":"magnesium-gummy-60ct","title":"Magnesium Gummy 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Convenient way to increase daily magnesium intake\u003cbr\u003e* Higher magnesium intakes support emotional well-being, positive mood, relaxation and a healthy stress response\u003cbr\u003e* Excellent source of magnesium (150 mg per gummy)\u003cbr\u003e* One gummy contains as much magnesium as 46 almonds14\u003cbr\u003e* Highly bioavailable form of magnesium\u003cbr\u003e* Less than 0.5 g of sugar per gummy\u003cbr\u003e* Great-tasting berry vanilla flavor\u003cbr\u003e* Made with no gelatin\u003cbr\u003e* Free from artificial flavors, sweeteners or synthetic colors\u003cbr\u003e* Suitable for vegans and vegetarians\u003cbr\u003e* Made with hypoallergenic, vegan ingredients\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, adults and children ages 9 and up, take 1 gummy daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 9 and up\u003cbr\u003e* For individuals who have difficulty meeting magnesium requirements from diet alone\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eMany U.S. adults fall short of the recommended dietary allowance (RDA; 400-420 mg for men and 310-320 mg for women). Nearly half (48%) of Americans fail to meet the estimated average requirement (EAR) for magnesium (255-350 mg), an amount that is estimated to meet the needs of 50% of healthy individuals.1 Magnesium plays essential roles in neuronal communication (neurotransmission), supporting the function of GABA and other key neurotransmitters with calming and relaxing effects.2-5 Accordingly, higher dietary magnesium intakes are associated with healthy responses to stress, positive mood, and emotional well-being.6-10 Magnesium also plays an important role in muscle relaxation.11-13 Each gummy provides 150 mg of magnesium citrate, a highly bioavailable form better absorbed than magnesium oxide.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. U.S. Department of Agriculture, Agricultural Research Service. Usual Nutrient Intake from Food and Beverages, by Gender and Age, What We Eat in America, NHANES 2013-2016; 2019.\u003cbr\u003e2. Gröber U, Schmidt J, Kisters K. *Nutrients*. 2015 Sep 23;7(9):8199-226.\u003cbr\u003e3. Poleszak E, Wlaź P, Wróbel A, et al. *Pharmacol Rep*. 2008 Sep-Oct;60(5):655-63.\u003cbr\u003e4. Hou H, Wang L, Fu T, et al. *Mol Neurobiol*. 2020 Jun;57(6):2539-50.\u003cbr\u003e5. Papadopol V, Nechifor M. In: Vink R, Nechifor M, editors. ++Magnesium in the Central Nervous System++ [Internet]. Adelaide (AU): University of Adelaide Press; 2011.\u003cbr\u003e6. Jacka FN, Overland S, Stewart R, et al. *Aust N Z J Psychiatry*. 2009 Jan;43(1):45-52.\u003cbr\u003e7. Tarleton EK, Littenberg B, MacLean CD, et al. *PLoS One*. 2017 Jun 27;12(6):e0180067.\u003cbr\u003e8. Singewald N, Sinner C, Hetzenauer A, et al. *Neuropharmacology*. 2004 Dec;47(8):1189-97.\u003cbr\u003e9. Macian N, Dualé C, Voute M, et al. *Nutrients*. 2022 May 17;14(10):2088.\u003cbr\u003e10. Pickering G, Mazur A, Trousselard M, et al. *Nutrients*. 2020 Nov 28;12(12):3672.\u003cbr\u003e11. Carvil P, Cronin J. *Strength Cond J*. 32(1):p 48-54, Feb 2010.\u003cbr\u003e12. Vallee BL, Wacker WE, Ulmer DD. *N Engl J Med*. 1960 Jan 28;262:155-61.\u003cbr\u003e13. Wacker WEC, Moore FD, Ulmer DD, Vallee BL. *JAMA*.1962;180(2):161--163.\u003cbr\u003e14. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, 2019. fdc.nal.usda.gov.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Magnesium citrate is from elemental ore and corn dextrose fermentation\u003cbr\u003e* Chicory root fiber is derived from chicory inulin\u003cbr\u003e* Pectin is derived from citrus peel\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302981828,"sku":null,"price":24.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/9b1515946b8e96c60b684e93c890d05255d3164636fa819209a15c334c33129f.avif?v=1781891572"},{"product_id":"microdefense-w-oregano-90ct","title":"MicroDefense w\/ Oregano 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e\n* Supports healthy gastrointestinal tract function and microbial balance^‡^\u003cbr\u003e\n* Made with high-quality vegetarian ingredients backed by verifiable science\u003cbr\u003e\n* Promotes healthy gastrointestinal tract function and microbial balance^‡^\u003cbr\u003e\n* Supports immune function and respiratory tract balance^‡^\u003cbr\u003e\n* Comprised of a combination of plant extracts\u003cbr\u003e\n* Part of the PureGI^™^ product line\u003cbr\u003e\n* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e\nAs a dietary supplement, take 1 capsule, 1-3 times daily, just before a meal, with 6-8 oz water, for 2-3 months, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eIndications:\u003cbr\u003e\n* Ages 18 and up\u003cbr\u003e\n* Gastrointestinal health support^‡^\u003cbr\u003e\n* Immune system support^‡^\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e\nArtemisia, which contains artemisinin, has been used traditionally for thousands of years to promote healthy microbial balance within the body.^1^ Olive leaf extract contains the active constituent oleuropein, a phenolic glucoside that helps maintain healthy G.I. and respiratory tract microorganism balance and may help support immune function.^2^ Oregano oil powder offers antioxidant and microbial balancing properties. In vitro and animal research suggests that oregano oil and clove can diffuse through microbial cell membranes, promoting membrane permeability.^3^ Clove has been used traditionally to promote healthy fungal and microbial levels.^4^ Berberine sulfate is a highly concentrated microbial balancing compound.^5‡^\u003c\/p\u003e\n\n\u003cp\u003eReferences:\u003cbr\u003e\n1. Oguche S, et. al. *Am J Trop Med Hyg.* 2014 Nov;91(5):925-35\u003cbr\u003e\n2. Takeda R, et. al. *Phytomedicine.* 2013 Jul 15;20(10):861-4.\u003cbr\u003e\n3. Force M, et al. *Phytother.* Res. 2000: 14, 213?214\u003cbr\u003e\n4. Bansal V, et. al. *Niger Med J.* Nov-Dec 2019;60(6):285-289.\u003cbr\u003e\n5. Khin-Maung-U, et. al. *Br Med J (Clin Res Ed).* 1985 Dec 7;291(6509):1601-5.\u003c\/p\u003e\n\n\u003cp\u003eWarning:\u003cbr\u003e\nNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\n\u003cp\u003eStorage:\u003cbr\u003e\nStore in a cool, dry place.\u003c\/p\u003e\n\n\u003cp\u003eSource:\u003cbr\u003e\n* Berberine sulfate is derived from *Berberis aristata* stem\/root and sulfuric acid\u003cbr\u003e\n* Olive leaf extract is derived from *Olea europaea* and standardized to contain min. 15% oleuropein\u003cbr\u003e\n* Artemisia extract is derived from *Artemisia* *annua* whole plant and standardized to typically contain 5% artemisinin\u003cbr\u003e\n* Clove is derived from *Syzygium aromaticum*whole plant\u003cbr\u003e\n* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303014596,"sku":null,"price":37.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/5d123219a89f0f476ed3b63c2824c62f40a4feb429c3a1fbb5e470bf3942cf54.avif?v=1781891638"},{"product_id":"microdefense-w-oregano-180ct","title":"MicroDefense w\/ Oregano 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy gastrointestinal tract function and microbial balance\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003cbr\u003e* Promotes healthy gastrointestinal tract function and microbial balance\u003cbr\u003e* Supports immune function and respiratory tract balance\u003cbr\u003e* Comprised of a combination of plant extracts\u003cbr\u003e* Part of the PureGI™ product line\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, just before a meal, with 6-8 oz water, for 2-3 months, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Gastrointestinal health support\u003cbr\u003e* Immune system support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eArtemisia, which contains artemisinin, has been used traditionally for thousands of years to promote healthy microbial balance within the body.1 Olive leaf extract contains the active constituent oleuropein, a phenolic glucoside that helps maintain healthy G.I. and respiratory tract microorganism balance and may help support immune function.2 Oregano oil powder offers antioxidant and microbial balancing properties. In vitro and animal research suggests that oregano oil and clove can diffuse through microbial cell membranes, promoting membrane permeability.3 Clove has been used traditionally to promote healthy fungal and microbial levels.4 Berberine sulfate is a highly concentrated microbial balancing compound.5\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Oguche S, et. al. *Am J Trop Med Hyg.* 2014 Nov;91(5):925-35\u003cbr\u003e2. Takeda R, et. al. *Phytomedicine.* 2013 Jul 15;20(10):861-4.\u003cbr\u003e3. Force M, et al. *Phytother.* Res. 2000: 14, 213?214\u003cbr\u003e4. Bansal V, et. al. *Niger Med J.* Nov-Dec 2019;60(6):285-289.\u003cbr\u003e5. Khin-Maung-U, et. al. *Br Med J (Clin Res Ed).* 1985 Dec 7;291(6509):1601-5.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Berberine sulfate is derived from *Berberis aristata* stem\/root and sulfuric acid\u003cbr\u003e* Olive leaf extract is derived from *Olea europaea* and standardized to contain min. 15% oleuropein\u003cbr\u003e* Artemisia extract is derived from *Artemisia* *annua* whole plant and standardized to typically contain 5% artemisinin\u003cbr\u003e* Clove is derived from *Syzygium aromaticum*whole plant\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303047364,"sku":null,"price":69.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/5d123219a89f0f476ed3b63c2824c62f40a4feb429c3a1fbb5e470bf3942cf54_1.avif?v=1781891712"},{"product_id":"metabolic-xtra-90ct","title":"Metabolic Xtra 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy insulin receptor function and signaling\u003cbr\u003e* Supports healthy glucose metabolism\u003cbr\u003e* Offers resVida® 99% pure trans-resveratrol\u003cbr\u003e* Provides 350 mg berberine HCl per capsule\u003cbr\u003e* Made with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy glucose metabolism\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eMetabolic Xtra provides a combination of nutrients to support healthy glucose metabolism and insulin receptor function and signaling. The natural plant alkaloid berberine enhances the expression and function of insulin receptors.1, 2 In a randomized, placebo-controlled trial involving 116 subjects, berberine provided statistically significant support for healthy glucose and lipid metabolism.3 Resveratrol has been shown to support cellular metabolism and glucose homeostasis by promoting healthy AMPK and SIRT1 protein levels.4, 5 The trace mineral chromium plays an important role in glucose and lipid metabolism, as well as enzyme activation.6, 7 Alpha lipoic acid provides support for healthy insulin receptor function and glucose metabolism.8, 9\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Zhang H, et al. Metabolism. 2010 Feb;59(2):285-92.\u003cbr\u003e2. Yan-xia N, et al. Chin J Integr Med. 1995; 1(2); 91-95.\u003cbr\u003e3. Zhang Y, et al. J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65.\u003cbr\u003e4. Timmers S, et al. Cell Metab. 2011 Nov 2;14(5):612-22.\u003cbr\u003e5. Crandall JP, et al. J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1307-12.\u003cbr\u003e6. Frauchiger MT, et al. J Am Coll Nutr. 2004 Aug;23(4):351-7.\u003cbr\u003e7. Rabinovitz H, et al. Int J Vitam Nutr Res. 2004 May;74(3):178-82.\u003cbr\u003e8. Jacob S, et al. Free Radic Biol Med. 1999 Aug;27(3-4):309-14.\u003cbr\u003e9. Ansar H, et al. Saudi Med J. 2011 Jun;32(6):584-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Berberine HCl is derived from Phellodendron amurense bar and Sargent’s barberry (*Berberis sargentiana*)\u003cbr\u003e* Alpha lipoic acid (thioctic acid), chromium dinicocysteinate and resveratrol are synthetic\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303080132,"sku":null,"price":56.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/0e5eb677df0b9a1f7707db535a707686d58d69b1e006a2a8c6f162e7adfaa483.avif?v=1781891776"},{"product_id":"niacinamide-90ct","title":"Niacinamide 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Support healthy glucose metabolism\u003cbr\u003e* Helps to maintain healthy pancreatic beta cell function\u003cbr\u003e** Promotes joint mobility and comfort\u003cbr\u003e* Does not cause the vasodilatation (\"flush\") associated with niacin\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-3 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Glucose metabolism and metabolic function\u003cbr\u003e* Joint health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eNiacinamide does not cause the vasodilatation (\"flush\") associated with niacin. Research indicates that niacinamide may support healthy glucose metabolism and protect pancreatic beta cell function.1 In a meta-analysis of 10 randomized controlled trials, niacinamide supplementation promoted healthy C-peptide levels, insulin metabolism and beta cell function.2 In another study, niacinamide helped maintain healthy C-peptide levels and glucose metabolism.3 In a 12-week randomized double-blind trial involving 72 subjects, niacinamide provided statistically significant support for joint flexibility.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Ding Y, et al. Clin Nutr. 2015 Oct;34(5):838-44.\u003cbr\u003e2. Pozzilli P, et al. The Nicotinamide Trialists. Diabetes Care. 1996 Dec;19(12):1357-63.\u003cbr\u003e3. Pozzilli P, et al. Diabetologia. 1995 Jul;38(7):848-52.\u003cbr\u003e4. Jonas WB, et al. Inflamm Res. 1996 Jul;45(7):330-4.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Niacinamide and alpha lipoic acid are synthetic\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303112900,"sku":null,"price":21.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/b10515e093b58d79628706824ae68b4424781b134a318e8802d6f7c0bf58aa2e.avif?v=1781891839"},{"product_id":"optiferin-c-60ct","title":"OptiFerin-C 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports red blood cells to help effectively transport oxygen in the body\u003cbr\u003e* Promotes healthy ferritin levels to maintain energy and well-being\u003c\/p\u003e\n\u003cp\u003e* Unique patented chemistry for enhanced iron utilization\u003cbr\u003e* Small capsules for easy swallowing\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, with meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Red blood cell and energy support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eOptiFerin-C is an iron-based supplement formulated to support red blood cells in order to help effectively transport oxygen in the body. Ferrochel® brand iron bis-glycinate was developed using unique patented chemistry, allowing it to be absorbed rapidly from the lumen of the intestine into mucosal cells and then released for transport throughout the body. The intestinal mucosal tissue tightly controls the release of Ferrochel® , supporting the safety profile of this iron amino acid chelate.1 In a double-blind, randomized, placebo-controlled trial, iron supplementation supported healthy ferritin levels, energy and well-being in female subjects.2 Research emphasizes the importance of maintaining healthy serum ferritin for optimal performance, particularlyin elite female athletes.3 This formula includes buffered vitamin C (as calcium ascorbate) to help enhance the absorption of iron.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Ashmead HD. *Arch Latinoam Nutr*. 2001 Mar;51(1 Suppl 1):13-21.\u003cbr\u003e2. Coplin M, et al. *Clin Ther*. 1991 Sep-Oct;13(5):606-12.\u003cbr\u003e3. DellaValle DM, et al. *Med Sci Sports Exerc*. 2014 Jun;46(6):1204-15.\u003cbr\u003e4. Hunt JR, et al. *Am J Clin Nutr*. 1990. 51(4); 649-655\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ferrochel® brand iron bis-glycinate is developed using unique patented chemistry, allowing it to be absorbed rapidly from the lumen of the intestines into mucosal cells and then released for transport throughout the body. The intestinal mucosal tissue tightly controls the release of Ferrochel® , supporting the safety profile of this iron amino acid chelate.\u003cbr\u003e* Ester-C® calcium ascorbate is manufactured from ascorbic acid and calcium carbonate. The calcium carbonate is mined domestically. The ascorbic acid is derived from corn fermentation.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303145668,"sku":null,"price":16.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/8c26c58a8362f4d64c75f19f3fbd010c80fe511382ef9346ac59d0592a83fe98.avif?v=1781891908"},{"product_id":"probiomood-capsules-shelf-stable-60ct","title":"ProbioMood (capsules) [Shelf-Stable] 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes emotional well-being and relaxation\u003cbr\u003e* Maintains healthy urinary cortisol levels\u003cbr\u003e* Clinically researched combination of probiotic strains\u003cbr\u003e* Developed using an innovative, patented microencapsulation process designed to protect the probiotic strains from harsh conditions, including gastric acidity\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Positive mood, relaxation and emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eProbioMood offers a clinically researched probiotic combination of strains developed using an innovative, patented microencapsulation process. This technology protects the probiotic strains from harsh conditions, including gastric acidity, compression and thermal shock. This probiotic strain combination offers unique support for emotional well-being and relaxation. Research suggests that *Lactobacillus helveticus Rosell-52* and *Bifidobacterium longum Rosell-175* support emotional health, in part by supporting healthy cytokine balance and intestinal integrity.1, 2 In a randomized, double-blind, placebo-controlled trial, supplementation with this combination maintained healthy urinary cortisol levels, indicating the potential to lessen occasional stress. In a separate analysis, supplemented subjects reported positive mood, relaxation and enhanced cognitive function.3, 4 In another randomized, double-blind, placebo-controlled trial, *L. helveticus Rosell-52* and *B. longum Rosell-175* moderated the normal gastrointestinal stress response by 49%.5‡\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Arseneault-Bréard J, et al. *Br J Nutr.* 2012 Jun;107(12):1793-9.\u003cbr\u003e2. Rao AV, et al. *Gut Pathog.* 2009 Mar 19;1(1):6.\u003cbr\u003e3. Messaoudi M, et al. *Br J Nutr*. 2011 Mar;105(5):755-64.\u003cbr\u003e4. Messaoudi M, et al. *Gut Microbes.* 2011 Jul-Aug;2(4):256-61.\u003cbr\u003e5. Diop L, et al. *Nutr Res.* 2008 Jan;28(1):1-5.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eProbiotics may be contraindicated for immunocompromised individuals. If you are pregnant or lactating, have any health condition or are immunocompromised, or are taking any medication, consult your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e*Lactobacillus helveticus Rosell-52* ME and *Bifidobacterium longum Rosell-175* ME are grown on a medium that contains dairy and soy\u003cbr\u003eMaltodextrin is derived from corn and is GMO-free\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303178436,"sku":null,"price":44.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/1cb22207c70204ce5ec47e8d491a781b7f393de8874e1d606cca938419c8cbe1.avif?v=1781891968"},{"product_id":"puregg-25b-60ct","title":"PureGG 25B 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Highly researched *Lactobacillus rhamnosus GG* to support immune, G.I., and overall health across all ages\u003cbr\u003e* Human origin strain, selected for its resistance to gastric acidity, adhesion properties, and ability to support healthy gut microflora\u003cbr\u003e* Provides 25 billion CFU per capsule, one of the most characterized and clinically studied probiotic strains on the market\u003cbr\u003e* Soy-free, dairy-free formulation\u003cbr\u003e* Shelf-stable\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy immune system support\u003cbr\u003e* G.I. support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e*Lactobacillus rhamnosus GG* is one of the best characterized and widely utilized probiotic strains, with numerous clinical trials across all ages. It is a human origin strain, selected for its resistance togastric acidity, adhesion properties, and ability to support healthy gut microflora. Studies involving infants and children suggest that supplementation with *L. rhamnosus GG* supports healthy G.I. colonization, G.I. function, and immune function, particularly related to skin and respiratory health.1, 2 In a study involving children ages 1-7 attending daycare, *L. rhamnosus GG* offered statistically significant support for respiratory and immune health.3 Studies involving pregnant women suggest supplementation supports healthy gut microflora in the infant, as well as nutrient metabolism during pregnancy. In one study, infants whose mothers had received *L. rhamnosus GG* during pregnancy showed increased bifidobacterial diversity at Day 5 after birth.4 *L. rhamnosus GG* is well known for its favorable effects on bowel function, particularly abdominal comfort, bowel motility and occasional diarrhea.5 Studies involving infants and children suggest that supplementation with *L. rhamnosus GG* supports healthy G.I. colonization and G.I. function.6 It also promotes cytokine balance in the G.I. tract at the level of gene expression, and overall immunomodulatory support.7 In a double-blind, crossover study, *L. rhamnosus GG* supplementation moderated the neutrophil and monocyte immune response in dairy-challenged, milk-sensitive subjects, while promoting immune function in nonsensitive subjects.8 In another study, *L. rhamnosus GG* promoted healthy gene expression to supportwhite blood cell (WBC) function. Elderly subjects supplemented for 28 days showed 95 differentially expressed genes related to cellular movement, cell-to-cell signaling, and cytokine response.^9‡^\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Manzoni et al.*Clin Infect Dis.* 2006;42, 1735-42.\u003cbr\u003e2. Hatakka et al.*BMJ*2001, 322(7298), 1327.\u003cbr\u003e3. Hojsak et al.*Clin Nutr*2010; 29, 312-6.\u003cbr\u003e4. Gueimonde et al.*J Pediatr Gastroenterol Nutr.*2006, 42, 166-70.\u003cbr\u003e5. Guandalini et al.*J Pediatr Gastroenterol Nutr,*2000:30(1), 54-60\u003cbr\u003e6. Sindhu KN, et al. *Clin Infect Dis.* 2014 Apr;58(8):1107-15.\u003cbr\u003e7. Burton KJ, et al. *Br J Nutr.* 2017; May;117(9):1312-22.\u003cbr\u003e8. Pelto et al.*Clin Exp Allergy* 1998;28(12), 1474-79.\u003cbr\u003e9. Solano-Aguilar G, et al.*PLoS One.* 2016 Feb 9;11(2):e0147426.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eProbiotics may be contraindicated for immunocompromised individuals. If you are pregnant or lactating, have any health condition or are immunocompromised, or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e*Lactobacillus rhamnosus GG* is a human origin strain, and grown on an allergen-free medium without gluten, dairy or soy.\u003cbr\u003eHypoallergenic plant fiber is derived from pine.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303211204,"sku":null,"price":44.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/503b521f404717ea60501a8ef4a50b409c8ab21262880cc8d55c2aa250407a6d.avif?v=1781892032"},{"product_id":"puregenomics-ultramultivitamin-90ct","title":"PureGenomics® UltraMultivitamin 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eMultivitamin\/mineral complex targeting common genetic polymorphisms\u003cbr\u003eOffers pre-formed vitamin A for individuals with decreased conversion efficacy of carotenoids due to genetic variations in the enzyme BCMO1\u003cbr\u003eSupports healthy VDR activity with 100 mcg (4, 000 IU)vitamin D\u003cbr\u003eIncludes 100 mg of choline to support healthy methylation and cognitive function, particularly for individuals with MTHFR or PEMT genetic variations\u003cbr\u003eSupports healthy brain signaling and emotional balance with lithium and vitamin B12 as adenosylcobalamin and hydroxycobalamin\u003cbr\u003ePromotes cellular function with antioxidants vitamin C, ALA, and CoQ10, as well as NAC to support endogenous glutathione production\u003cbr\u003eModerates healthy estrogen metabolism and cell cycle activity with DIM\u003cbr\u003ePromotes macular health with a blend of lutein and zeaxanthin\u003cbr\u003eProvides vitamins A, B, C, D, E and K in highly bioavailable forms\u003cbr\u003eIncludes activated B vitamins, including pyridoxal-5-phosphate, riboflavin-5-phosphate, enhancedretention thiamin derivative benfotiamine and 800 mcg of Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate\u003cbr\u003eOffers vitamin B12 in a unique blend of adenosylcobalamin and hydroxycobalamin\u003cbr\u003eEnhanced absorption liposomal-like form of magnesium\u003cbr\u003ePart of the PureGenomics® product line\u003cbr\u003eConvenient, three-capsule-per-day dosing\u003cbr\u003eMade with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 3 capsules per day, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eComprehensive daily wellness support\u003cbr\u003eEnhanced support for common geneticpolymorphisms\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePureGenomics® UltraMultivitamin is designed to support optimal health with a comprehensive profile of bioavailable vitamins, chelated minerals and antioxidants. Specifically, it includes activated B vitamins and choline to support healthy methylation, which plays many essential roles including neurotransmission, vitamin assimilation, DNA synthesis and gene regulation.1 These processes maintain cardiovascular function, cognition, emotional wellness and cellular protection. Vitamin D supports healthy VDR activity.2 Additional cellular protection support is offered with the antioxidants alpha lipoic acid and CoQ10, as well as N-acetyl-L-cysteine to support endogenous glutathione production.3 Genetic variations in the SLC23A1 gene are associated with absorption of vitamin C. Folate is offered in this formula as Metafolin® 5-methyltetrahydrofolate (L-5-MTHF), the universally metabolized and biologically active form of folate, providing support for individuals with genetic variations in the MTHFR gene.4 Variations in MTHFD1 and PEMT, two genes involved in methylation, have been associated with increased choline needs.5 Vitamin B12 is offered as adenosylcobalamin, the active mitochondrial form, and hydroxycobalamin, a precursor of both methylcobalamin and adenosylcobalamin. Magnesium is provided in an innovative microencapsulation form to enhance absorption. Magnesium and lithium may help support cognitive function and emotional balance in some individuals.6 Preformed vitamin A, together with a blend of lutein and zeaxanthin, promote macular health for individuals with genetic variations in the enzyme BCMO1, which can decrease the conversion efficacy of carotenoids into retinal by up to 69%.7, 8 Enhanced-absorption diindolylmethane is also included to support healthy estrogen metabolism.9\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Jacob RA, et. al. *J Nutr*. 1999 Mar;129(3):712-7\u003cbr\u003e2. Wang TJ, et al. *Lancet*. 2010 Jul 17;376(9736):180-8.\u003cbr\u003e3. Girodon F, et. al. *J Am Coll Nutr*. 1997 Aug;16(4):357-65.\u003cbr\u003e4. Prinz-Langenohl R, et al. *Br J Pharmacol*. 2009 Dec; 158(8): 2014-2021.\u003cbr\u003e5. Kohlmeier M, et. al. *Proc Natl Acad Sci U S A*. 2005 Nov 1;102(44).\u003cbr\u003e6. Wienecke E, et. al. *MMW Fortschr Med*. 2016 Dec;158(Suppl 6):12-16\u003cbr\u003e7. Wang MX, et. Al. *Atherosclerosis*. 2013 Apr;227(2):380-5.\u003cbr\u003e8. Lietz G, et. al. *J Nutr*. 2012 Jan;142(1):161S-5S.\u003cbr\u003e9. Dalessandri KM, et. al. *Nutr Cancer*. 2004;50(2):161-7.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant and lactating women. Consult your healthcare practitioner before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitoredclosely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Vitamin K may be contraindicated with Coumadin (Warfarin). Do not exceed the dose recommended by your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eVitamin A: synthetic\u003cbr\u003eMixed carotenoids: *Blakeslea trispora*\u003cbr\u003eLutein: marigold flower extract\u003cbr\u003eZeaxanthin: synthetic\u003cbr\u003eVitamin C: corn dextrose fermentation\u003cbr\u003eAscorbyl palmitate: corn dextrose fermentation and palm oil\u003cbr\u003eVitamin D3 : cholesterol from wool fat (lanolin)\u003cbr\u003eVitamin E: purified soybean oil\u003cbr\u003eVitamin K1: synthetic\u003cbr\u003eVitamin K2 (menaquinone-7): geraniol and farnesol flower extracts\u003cbr\u003eVitamin B1 (thiamin HCl): synthetic\u003cbr\u003eVitamin B2 (riboflavin): corn dextrose fermentation\u003cbr\u003eNiacinamide: synthetic\u003cbr\u003eVitamin B5 (calcium pantothenate): synthetic\u003cbr\u003eVitamin B6 (pyridoxal HCl): synthetic\u003cbr\u003eVitamin B12 (hydroxycobalamin and adenosylcobalamin): corn dextrose fermentation\u003cbr\u003eFolate (Metafolin® , L-5-MTHF): synthetic\u003cbr\u003eBiotin: synthetic\u003cbr\u003eCholine: synthetic\u003cbr\u003eMinerals: naturally derived from elemental ore Sources of the mineral chelates include:\u003cbr\u003eCitrate: corn dextrose fermentation\u003cbr\u003eGlycinate and Orotate: synthetic\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303276740,"sku":null,"price":52.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/08334f33073061f0e6f710715359c854955c9ecb0abb69c6ea4c99d5d648739a.avif?v=1781892106"},{"product_id":"phosphatidylcholine-90ct","title":"Phosphatidylcholine 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Phospholipid-bound choline to support cellular function, cognitive function and liver health\u003cbr\u003e* Acts as a precursor for phospholipids and acetylcholine, a neurotransmitter involved in attention, memory and neuromuscular function\u003cbr\u003e* Supports fat metabolism in the liver to promote energy production\u003cbr\u003e* Provides choline source for pregnancy to support infant cognitive development\u003cbr\u003e* Soy-free, sunflower-derived phosphatidylcholine.\u003cbr\u003e* Part of the PureGenomics® product line\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Healthy liver function\u003cbr\u003e* Cellular health support\u003cbr\u003e* Pregnancy support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePhosphatidylcholine (PC) is a naturally occurring, integral component of the cellular membrane, adding fluidity and strength to cells. It serves as a source of choline, an important nutrient for methylation, cell-to-cell communication, cognition and liver function.1 Choline and its metabolites are the major source of methyl groups in the diet. Methylation plays many roles including neurotransmission, vitamin assimilation, DNA synthesis and gene regulation.2 Choline is required for the synthesis of phospholipids and acetylcholine, a neurotransmitter involved in attention, learning and memory. A 6-month double-blind, placebo-controlled trial suggested that choline-containing lecithin, alpha GPC supports memory in aging individuals. Animal research suggests an adaptogenic effect when exposed to stress.3 Certain genetic variations in MTHFR and PEMT, enzymes that play critical roles in methylation and choline synthesis, respectively, have been associated with increased dietary choline needs.4 Research indicates that choline intake is important for pregnant women, particularly those with PEMT and MTHFR genetic variations.5 Another clinical trial showed that women with PEMT and MTHFR genetic variations who consumed 480 mg of choline daily during pregnancy had offspring with faster processing speed than those who did not.6 PC also plays a significant role in the healthy transport and metabolism of lipids. A randomized, double blind, placebo-controlled trial suggested that choline-containing lecithin may help support healthy hepatic fat metabolism.7 Animal studies indicate that PC promotes healthy liver and pancreatic antioxidant activity.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. da Costa KA, et. al. *Am J Clin Nutr*.2006 Jul;84(1):88-94.\u003cbr\u003e2. Olthof MR, et.al. *Am J Clin Nutr*. 2005 Jul;82(1):111-7.\u003cbr\u003e3. Kumar R, et. al. *J Altern Complement Med*. 2002 Aug;8(4):487-92\u003cbr\u003e4. West AA, et. al. *J Acad Nutr Diet*.2014 Oct;114(10):1594-600\u003cbr\u003e5. Yan J, et. al. Am *J Clin Nutr*.2012 May;95(5)\u003cbr\u003e6. Caudill MA, et al. *FASEB J*.2018 Apr;32(4):2172-2180\u003cbr\u003e7. Fischer LM, et. al. *Am J Clin Nutr*.2010 Nov; 92(5): 1113?119.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you arepregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eDerived from sunflower, a source that is rich in polyunsaturated fatty acids, as opposed to animal-derived sources, which tend to be much higher in saturated fatty acids. There is no detectable GMO material in this product\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303309508,"sku":null,"price":49.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/4ee3bd30d6955bb8b0d6b8d90517d93dc9a185b12298d4306ecf1363dbc61438.avif?v=1781892164"},{"product_id":"pureheart-k2d-60ct","title":"PureHeart® K2D 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports cardiovascular health\u003cbr\u003e* Promotes calcium balance in vascular tissue\u003cbr\u003e* Targets vascular tissue to support healthy arterial blood flow and vascular elasticity\u003cbr\u003e* Contains naturally derived Vitamin K2 (menaquinone-7)\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-2 times daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Cardiovascular support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVitamin K2 (menaquinone-7) promotes healthy vascular calcium balance and cardiovascular function. In a systematic review involving fivestudies, higher intakes of vitamin K2 were associated with cardiovascular health.^1^ Research indicates that it supports the carboxylation of matrix Gla-protein (MGP), a key protein involved in calcium balance.2 Unlike vitamin K1, which promotes bone health, menaquinone-7 targets vascular tissue to support healthy arterial blood flow and vascular elasticity.3 In an observational study involving 564 postmenopausal women, higher intake of vitamin K2 was associated with calcium balance in the vascular tissue.4 Optimal serum levels of vitamin D are also important to maintain healthy calcium balance in vascular tissues, in part by supporting the activity of MGP.5 Studies indicate that the combination of vitamin K and D provides synergistic support.6 Vitamin K supplementation may be contraindicated for those taking Coumadin(warfarin), an anticoagulant medication.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Rees K, et al. *Maturitas*. 2010 Oct;67(2):121-8.\u003cbr\u003e2. Schurgers LJ, et al. *Blood*. 2007 Apr 15;109(8):3279-83.\u003cbr\u003e3. Vermeer C, et al. *Vascul Dis Ther*, 2020 5:\u003cbr\u003e4. Beulens JW, et al. *Atherosclerosis.*2009 Apr;203(2):489-93.\u003cbr\u003e5. Cranenburg EC, et al. *J Vasc Res*. 2008;45(5):427-36.\u003cbr\u003e6. Je SH, et al. *J Korean Med Sci*. 2011 Aug;26(8):1093-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eVitamin K may be contraindicated with Coumadin (warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin K2 (MK-7) is naturally derived from flower extracts geraniol and farneso\u003cbr\u003e* Vitamin D3 is derived from lanolin\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303375044,"sku":null,"price":48.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/pureheartk2d-60.avif?v=1781892233"},{"product_id":"poly-prebiotic-120ct","title":"Poly-Prebiotic 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Enhances Bifidobacterium and healthy gut microflora with a blend of XOS prebiotic and cranberry extract\u003cbr\u003e* Promotes gut barrier function\u003cbr\u003e* Supports colonocyte health and cytokine balance\u003cbr\u003e* Provides 1.4 g of clinically researched XOS per serving\u003cbr\u003e* Includes concentrated cranberry extract standardized to contain 1% proanthocyanidins (PACs)\u003cbr\u003e* Shelf-stable prebiotic support\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 3 capsules, 1-2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePrebiotics are nondigestible components of food that act to modulate and support the gut microbiota. Emerging evidence suggests that prebiotics may play an even more significant role than probiotics, serving metabolic, trophic and protective functions within the gut.1, 3 PreticX™ XOS (xylo-oligosaccharides) enhances the growth of Bifidobacteria, an important intestinal bacterial genus that maintains healthy gastrointestinal function.2-6 Clinical research also shows that XOS enhances the production of butyrate, a short chain fatty acid (SCFA) that serves as a major energy source for colonocytes.3, 4, 8 In preclinical models, XOS supports intestinal barrier function, cytokine balance and colon cell health.3 In a randomized, double-blind, placebo-controlled study, 32 healthy adult subjects were given 1.4 grams or 2.8 grams of PreticX™ XOS for 8 weeks. The Bifidobacterium count increased 21% from the baseline at 4 weeks and 17% from the baseline at 8 weeks in the highest dose group.4 In an in vitro study using clinical isolates from hospital patients, XOS was found to stimulate growth of all 35 Bifidobacterium strains in a dose-dependent manner. XOS also supported growth of 38%-62% of Lactobacilli strains tested.5 Evidence from a small clinical trial of 14 healthy women additionally suggests that XOS supports bowel regularity and emotional well-being. In contrast to FOS and other common prebiotics, studies on XOS and report very low incidence of gas and bloating.2, 4, 9 This formula also provides cranberry, which favorably modulates intestinal microbiota in preclinical models, supporting the abundance of beneficial taxa such as Bifidobacteria and Bacteroidaceae.7, 10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Simon E, Călinoiu LF, Mitrea L, Vodnar DC. Nutrients. 2021 Jun 20;13(6):2112.\u003cbr\u003e2. Childs CE, Röytiö H, Alhoniemi E, et al. Br J Nutr. 2014 Jun 14;111(11):1945-56.\u003cbr\u003e3. Pham VT, Calatayud M, Rotsaert C, et al. Nutrients. 2021 Mar 29;13(4):1125.\u003cbr\u003e4. Finegold SM, Li Z, Summanen PH, Downes J, et al. Food Funct. 2014 Mar;5(3):436-45.\u003cbr\u003e5. Zhaoping L, et al. Int J Food Sci Nutr. 2015;66(8):919-22.\u003cbr\u003e6. Na MH, et al. Korean J Nutr. 2007 Mar;40(2):154-161.\u003cbr\u003e7. O'Connor K, et al. PLoS One. 2019 Nov 12;14(11):e0224836.\u003cbr\u003e8. Fei Y, Wang Y, Pang Y, et al. Front Physiol. 2020 Jan 22;10:1601.\u003cbr\u003e9. Yang J, Summanen PH, Henning SM, et al. Front Physiol. 2015 Aug 7;6:216.\u003cbr\u003e10. Cai X , Han Y, Gu M, et al. Food Funct. 2019 Oct 16;10(10):6331-6341.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* XOS is derived from corn cob\u003cbr\u003e* Cranberry extract is derived from Vaccinium macrocarpon fruit and standardized to contain 1% proanthocyanidins\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275303407812,"sku":null,"price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e93d6ff9dbbe56381a4050c344d3cdf923d4f0072f48507f22fceff90848e984_1.avif?v=1781892618"}],"url":"https:\/\/valvistapharmacy.com\/collections\/all.oembed","provider":"Val Vista Pharmacy","version":"1.0","type":"link"}