{"title":"Mental Health \u0026 Stress Support","description":null,"products":[{"product_id":"calm-mind-60ct","title":"Calm Mind 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports emotional well-being\u003cbr\u003e* Supports a positive mood and emotional outlook\u003cbr\u003e* Promotes a calm state of mind\u003cbr\u003e* Supports sleep with continued use\u003cbr\u003e* Clinically studied saffron (affron®)\u003cbr\u003e* Clinically studied curcumin (Theracurmin®) with 27x enhanced bioavailability\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Patients seeking support for mood and emotional well-being\u003cbr\u003e* Patients experiencing occasional stress and\/or sleeplessness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eCalm Mind combines two clinically studied botanical extracts, saffron (affron®) and curcumin (Theracurmin®), to support a positive mood, a calm state of mind and emotional well being. In a double-blind trial involving 128 adults self-reporting low mood, saffron (affron®, 28 mg\/day) resulted in a significant decrease in negative mood and symptoms related to stress after 4 weeks compared to placebo.1 Other studies indicate that saffron also supports sleep with continued use.2-4 The regulation of mood and emotional state is influenced by the immune system, and emerging research points to an impactful role of immune mediators known as cytokines.5 Lower plasma levels of certain cytokines, such as IL-6 and TNF-α, are associated with positive mood and emotional well-being.5, 6 In preclinical models, curcumin moderates the production of the cytokines IL-1β, IL-6, and TNF-α5, 6 and moderates pro-inflammatory cytokine pathways in the brain.7, 8 However, the low oral bioavailability of curcumin may limit its ability to support brain function. Theracurmin® is 27 times more bioavailable than standard curcumin.9 In a study of 40 adults (51--84 years of age) Theracurmin® containing 90 mg curcumin twice daily for 18 months significantly improved short-term, verbal and visual memory and attention.10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kell G, et al. *Complement Ther Med*. 2017 Aug;33:58-64.\u003cbr\u003e2. Nishide A, et al. *Jpn Pharmacol Ther*. 2018;46:8.\u003cbr\u003e3. Lopresti AL, et al. *Sleep Med*. 2021 Oct;86:7-18.\u003cbr\u003e4. Lopresti AL et al. *J Clin Sleep Med*. 2020 Jun 15;16(6):937-947.\u003cbr\u003e5. Hassamal S. *Front Psychiatry*. 2023 May 11;14:1130989.\u003cbr\u003e6. Fan N, et al. *Hum Psychopharmacol*. 2017 Jul;32(4).\u003cbr\u003e7. Fan C, et al. *Neuroscience*. 2018 Nov 10;392:92-106.\u003cbr\u003e8. Wang Z, et al. *Behav Brain Res*. 2014 Nov 1;274:282-90.\u003cbr\u003e9. Sasaki H, et al. *Biol Pharm Bull*. 2011;34(5):660-5.\u003cbr\u003e10. Small GW, et. al. *Am J Geriatr Psychiatry*. 2018 Mar;26(3):266-277\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or taking any medication, consult your healthcare professional before use. Keep out of the reach of children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Turmeric extract is derived from *Curcuma longa L*. rhizome and standardized for curcumin\u003cbr\u003e* Saffron extract is derived from *Crocus sativus* stigma and standardized for Lepticrosalides™\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275299868868,"sku":null,"price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/clm6_rgb_1.avif?v=1781887263"},{"product_id":"rapid-mental-energy-30ct","title":"Rapid Mental Energy 30ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Sharpens working memory\u003cbr\u003e* Supports alertness\u003cbr\u003e* Supports cognitive performance\u003cbr\u003e* Two clinically backed ingredients\u003cbr\u003e* Not known to interfere with sleep\u003cbr\u003e* Can be safely used with caffeine\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* As-needed support for alertness and working memory\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRapid Mental Energy combines clinically studied extracts, Alpinia galanga (enXtra) and American ginseng (Cereboost®), to support alertness and sharpen working memory.1-5 In a randomized, double-blind, placebo-controlled crossover study, enXtra significantly increased alertness scores from baseline values at 1 hour, 3 hours and 5 hours after a single 300 mg dose.1 Alertness scores were significantly greater in the enXtra group compared to placebo (p=0.04) at 3 hours post-dose. While enXtra supports alertness and attention network function (the ability to direct mental resources to a specific task), Cereboost® provides fast-acting support for acute visuospatial and verbal short-term (working) memory.1-5 in a study of 52 healthy middle-aged adults, Cereboost® (200 mg) improved working memory 3 hours after a single dose2 In a randomized controlled clinical trial of 61 healthy young adults, daily use of Cereboost® (200 mg) improved working memory and attention.3 In a randomized, double-blind crossover trial of 32 healthy volunteers, a single dose of Cereboost® (200 mg) improved working memory (immediate word recall and visuo-spatial information retrieval) at 1 hour post-dose and was sustained over a 6 hour testing period.4 The ginsenosides in Cereboost® support cholinergic neurotransmission in the hippocampus and prefrontal cortex, key brain regions involved in learning and memory.5 \u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Srivastava S, Mennemeier M, Pimple S. J Am Coll Nutr. 2017 Nov-Dec;36(8):631-639. doi: 10.1080\/07315724.2017.1342576.\u003cbr\u003e2. Bell L, Whyte A, Duysburgh C, et al. Eur J Nutr. 2022 Feb;61(1):413-428.\u003cbr\u003e3. Ossoukhova A, Owen L, Savage K, et al. Human Psychopharmacol. 2015;30(2):108--122.\u003cbr\u003e4. Scholey A, Ossoukhova A, Owen L, et al. Psychopharmacology. 2010;212(3):345--356.\u003cbr\u003e5. Shin K, Guo H, Cha Y, et al. Regul Toxicol Pharmacol. 2016 Jul;78:53-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* *Alpinia galanga* extract is derived from the rhizome\u003cbr\u003e* American ginseng is derived from *Panax quinquefolius* L. root extract and standardized for ginsenosides\u003cbr\u003e* Ginkgo is derived from *Ginkgo biloba* leaf extract and standardized for ginkgoheterosides and terpene lactones\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300884676,"sku":null,"price":35.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/rme3.avif?v=1781888572"},{"product_id":"daily-calm-60ct","title":"Daily Calm 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports relaxation with continued use\u003cbr\u003e* Supports a positive mood\u003cbr\u003e* Supports a relaxed and alert mental state\u003cbr\u003e* Supports sleep with continued use\u003cbr\u003e* Clinically studied L-theanine (Suntheanine®)\u003cbr\u003e* Clinically studied ashwagandha (KSM-66®)\u003cbr\u003e* Clinically studied saffron (affron®)\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional anxiety\u003cbr\u003e* Occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eDaily Calm combines L-theanine, saffron, GABA, and ashwagandha to relieve occasional stress and anxiety while supporting a positive, relaxed mood and emotional well-being. Suntheanine®, a trademarked L-theanine, supports a relaxed and alert mental state. A four-week randomized clinical trial using L-theanine found support for stress-related symptoms.1 Clinical research shows that saffron, a widely studied spice derived from the flower of *Crocus sativus* , supports emotional well-being and positive mood.2-4 Clinical studies also show that saffron supports sleep with continued use.5, 6 Ashwagandha, an adaptogenic herb, helps the body adapt to stress by restoring balance. Studies show that ashwagandha supports a calm, relaxed mood, helping to relieve occasional anxiety and stress.7-9 Together, these ingredients support multiple aspects of emotional wellness, helping to relieve occasional stress and anxiety while supporting a positive emotional outlook and sleep quality with continued use.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Hidese S, Ogawa S, Ota M, et al. *Nutrients*. 2019 Oct 3;11(10):2362.\u003cbr\u003e2. Tóth B, Hegyi P, Lantos T, et al. *Planta Med.* 2019 Jan;85(1):24-31. doi: 10.1055\/a-0660-9565.\u003cbr\u003e3. Kashani L, Eslatmanesh S, Saedi N, et al. *Pharmacopsychiatry*. 2017 Mar;50(2):64-68. doi: 10.1055\/s-0042-115306.\u003cbr\u003e4. Kell G, Rao A, Beccaria G, et al. *Complement Ther Med*. 2017 Aug;33:58-64. doi: 10.1016\/j.ctim.2017.06.001.\u003cbr\u003e5. Pachikian BD, Copine S, Suchareau M, Deldicque L. *Nutrients*. 2021 Apr 27;13(5):1473. doi: 10.3390\/nu13051473.\u003cbr\u003e6. Lopresti AL, Smith SJ, Metse AP, Drummond PD. *J Clin Sleep Med.* 2020 Jun 15;16(6):937-947. doi: 10.5664\/jcsm.8376.\u003cbr\u003e7. Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. *Cureus*. 2019 Sep 28;11(9):e5797. doi: 10.7759\/cureus.5797.\u003cbr\u003e8. Salve J, Pate S, Debnath K, Langade D. *Cureus*. 2019 Dec 25;11(12):e6466.\u003cbr\u003e9. Kelgane SB, Salve J, Sampara P, Debnath K. Cureus 2020; 12(2): e7083.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ashwagandha extract is derived from *Withania somnifera* root and standardized for withanolides\u003cbr\u003e* GABA (gamma-aminobutyric acid) and L-theanine are synthetic\u003cbr\u003e* Saffron is derived from *Crocus sativus* stigma extract and standardized for Lepticrosalides®\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300917444,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dcm6-1_1_1.avif?v=1781888648"},{"product_id":"rapid-calm-30ct","title":"Rapid Calm 30ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps to moderate general feelings of stress and occasional anxiety\u003cbr\u003e* Provides vitamin B6, a cofactor in the biosynthesis of serotonin\u003cbr\u003e* Contains clinically studied Zembrin®\u003cbr\u003e* Contains Suntheanine®, a clinically studied L-theanine\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Support for occasional anxiety in less than one hour\u003cbr\u003e* Support for occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRapid Calm delivers rapid-acting support for occasional anxiety in less than one hour. Zembrin®, a patented extract of *Sceletium tortuosum* , has been clinically studied and shown to help moderate general feelings of stress and occasional anxiety. In a clinical trial, a single dose of 25 mg Zembrin® reduced perceived levels of occasional anxiety and its physical symptoms, such as elevated heart rate, in healthy volunteers, within 1 hour.1 In another randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using pharmaco-fMRI.2 The amygdala is a part of the brain that reacts to threats and communicates with the rest of the related areas of the brain to regulate feelings of fear and nervousness in threatening situations. In vitro evidence indicates that Zembrin® might work by inhibiting serotonin reuptake, prolonging the effects of serotonin.3 Serotonin is a neurotransmitter involved in relaxation and mood. L-theanine complements Zembrin® by supporting a relaxed and alert mental state.4 Vitamin B6 is a cofactor in the biosynthesis of serotonin.5 This formula is ideal for as-needed relief from occasional everyday stressors.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Reay J, Wetherell MA, Morton E. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002\/hup.2753. Epub 2020 Aug 6. PMID: 32761980.\u003cbr\u003e2. Terburg D, Syal S, Rosenberger LA, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16. doi: 10.1038\/npp.2013.183.\u003cbr\u003e3. Harvey AL, Young LC, Viljoen AM, Gericke NP. J Ethnopharmacol. 2011 Oct 11;137(3):1124-9. doi: 10.1016\/j.jep.2011.07.035.\u003cbr\u003e4. Hidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390\/nu11102362.\u003cbr\u003e5. Blau N, Pearson TS, Kurian MA, et al. 2023 Oct 12. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach out children.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Vitamin B6 and L-theanine are synthetic\u003cbr\u003e* *Sceletium tortuosum* is derived from aerial parts extract\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275300950212,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/rcm3_rgb.avif?v=1781888719"},{"product_id":"amino-replete-8-5oz","title":"Amino Replete 8.5oz","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports athletic activity, cognitive function and daily wellness\u003cbr\u003e* Promotes immune function\u003cbr\u003e* Convenient powder formula for easy dispensing\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 scoop daily, mixed with 8 ounces of water or juice, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Daily wellness support\u003cbr\u003e* Athletic activity support\u003cbr\u003e* Immune and positive mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eOffers a comprehensive blend of free-form amino acids, provided in the ratios found naturally in high biological value (BV) protein sources. Maintains daily wellness with amino acid building blocks to support protein synthesis.1 Supports athletic training, including muscle performance, energy production and recovery.2 Enhances healthy neurotransmitter synthesis with amino acid precursors to support cognitive function and positive mood.3 Promotes immune function, in part by supporting healthy glutamine and glutathione levels.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Bukhari SS, et al. *Am J Physiol Endocrinol Metab.* 2015 Jun 15;308(12):E1056-65.\u003cbr\u003e2. Ohtani M, et al. *J Nutr*. 2006. 136: 538-43.\u003cbr\u003e3. Lehnert H, et al. *Psychother Psychosom*. 1993;60(1):18-32.\u003cbr\u003e4. Bassit RA, et al. *Med Sci Sports Exerc*. 2000 Jul;32(7):1214-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003ePHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* L-arginine, L-glutamine, L-histidine, L-lysine, L-threonine, L-phenylalanine, L-tryptophan, L-methionine, L-serine, L-Isoleucine, L-valine and L-leucine are produced by fermentation\u003cbr\u003e* L-alanine is derived from enzymatic synthesis from aspartic acid\u003cbr\u003e* L-tyrosine is derived from corn\u003cbr\u003e* Glycine and L-methionine are produced synthetically\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275301507268,"sku":null,"price":53.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/b95a0ee4c16243caabe95460433b635cc5e4a9da87e774dba32588abad03c75a.avif?v=1781889173"},{"product_id":"lithium-orotate-1-mg-90ct","title":"Lithium (orotate) 1 mg 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy mood, memory and behavior\u003cbr\u003e* Supports neurotransmitter activity\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003e* Part of the PureSYNAPSE™ product line\u003cbr\u003e* Made with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional wellness and mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLithium (orotate) 1 mg provides the nutritionally essential trace element lithium Lithium is an essential micronutrient with some chemical properties similar to calcium and magnesium. It is present in all organs and tissues in the body. Lithium has a long history of clinical use for supporting healthy mood and behavior, possibly through dopamine- and serotonin- mediated mechanisms.1-3 Lithium supports neurotransmitter systems and signaling cascades involved in brain health and behavior.1, 3 Several studies suggest that lithium supports memory and mood.1, 4, 5 A 12-month, randomized, double-blind trial involving 45 individuals suggests that low-dose lithium supplementation promotes cognitive performance.6 In cultured neurons, lithiumenhanced gene expression of glutathione-S-transferase (GST), a natural detoxification enzyme with neuroprotective functions.7 Lithium also has been shown to promote healthy brain-derived neurotrophic factor (BDNF) levels in animal models and humans.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Szklarska D, Rzymski P. Biol Trace Elem Res 189, 18-27 (2019).\u003cbr\u003e2. Beaulieu JM, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104.\u003cbr\u003e3. Schrauzer GN, et al. Biol Trace Elem Res. 1994 Jan;40(1):89-101.\u003cbr\u003e4. Nunes MA, et al. Curr Alzheimer Res. 2013 Jan;10(1):104-7.\u003cbr\u003e5. Forlenza OV, et al. Br J Psychiatry. 2011 May;198(5):351-6.\u003cbr\u003e6. Straten G. Curr Alzheimer Res. 2011 Dec;8(8):853-9.\u003cbr\u003e7. Shao L, et al. Neuroscience. 2008 Jan 24;151(2):518-24.\u003cbr\u003e8. Leyhe T, et al. J Alzheimers Dis. 2009;16(3):649-56.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Lithium is mined and refined\u003cbr\u003e* Orotate and N-acetyl-l-cysteine are synthetically derived\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypo-allergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275302850756,"sku":null,"price":17.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/a820b6161929e39d19507e512d737508d03ea36b896d60f067faae6b73b31de4.avif?v=1781891322"},{"product_id":"adr-formula-60ct","title":"ADR Formula® 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Support for the adrenal glands\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Helps maintain a healthy immune response\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis formula combines whole adrenal and adrenal cortex with a blend of herbs and nutrients to support the function of the adrenal glands. Whole adrenal and adrenal cortex nutritionally support the proper functioning of the adrenal glands. Both *Eleutherococcus senticosus* and *Panax ginseng* have adaptogenic properties to help balance physiological functions in the body's including adrenal gland function.1, 2 Licorice extract helps to maintain healthy cortisol metabolism, while calcium pantothenate promotes healthy adrenal gland activity.3 *Eleutherococcus senticosus* and *Panax ginseng* also support a healthy stress response and immune function.2, 4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kim HG, et. al. *PLOS One* 2013 Apr 17;8(4):e61271.\u003cbr\u003e2. Gaffney BT, et. al. *Life Sci.*. 2001 Dec 14;70(4):431-42.\u003cbr\u003e3. Al-Dujaili EA, et. al. *Mol Cell Endocrinol*. 2011 Apr 10;336(1-2):102-9.\u003cbr\u003e4. Nguyen NH, Nguyen CT. *Inflammopharmacology.* 2019 Oct;27(5):871-3.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Whole adrenal and adrenal cortex are derived from pasture-fed, pesticide-free bovine herds. These glandular extracts are freeze-dried and vacuum-dried.\u003cbr\u003e* *Panax ginseng* extract is derived from the root and standardized to contain 5% total ginsenosides.\u003cbr\u003e* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutherosides.\u003cbr\u003e* Licorice extract is derived from the root and standardized to contain 20% glycyrrhizic acid.\u003cbr\u003e* Calcium pantothenate (vitamin B5 ) is synthetic.\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275304194244,"sku":null,"price":46.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/1ed2f0b25a80761cd83dd529f55520a5a277c667449cfe4b0b25a230c05cf25b_1.avif?v=1781951864"},{"product_id":"adr-formula-120ct","title":"ADR Formula® 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Support for the adrenal glands\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Helps maintain a healthy immune response\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis formula combines whole adrenal and adrenal cortex with a blend of herbs and nutrients to support the function of the adrenal glands. Whole adrenal and adrenal cortex nutritionally support the proper functioning of the adrenal glands. Both *Eleutherococcus senticosus* and *Panax ginseng* have adaptogenic properties to help balance physiological functions in the body's including adrenal gland function.1, 2 Licorice extract helps to maintain healthy cortisol metabolism, while calcium pantothenate promotes healthy adrenal gland activity.3 *Eleutherococcus senticosus* and *Panax ginseng* also support a healthy stress response and immune function.2, 4‡\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kim HG, et. al. *PLOS One* 2013 Apr 17;8(4):e61271.\u003cbr\u003e2. Gaffney BT, et. al. *Life Sci.*. 2001 Dec 14;70(4):431-42.\u003cbr\u003e3. Al-Dujaili EA, et. al. *Mol Cell Endocrinol*. 2011 Apr 10;336(1-2):102-9.\u003cbr\u003e4. Nguyen NH, Nguyen CT. *Inflammopharmacology.* 2019 Oct;27(5):871-3.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Whole adrenal and adrenal cortex are derived from pasture-fed, pesticide-free bovine herds. These glandular extracts are freeze-dried and vacuum-dried.\u003cbr\u003e* *Panax ginseng* extract is derived from the root and standardized to contain 5% total ginsenosides.\u003cbr\u003e* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutherosides.\u003cbr\u003e* Licorice extract is derived from the root and standardized to contain 20% glycyrrhizic acid.\u003cbr\u003e* Calcium pantothenate (vitamin B5 ) is synthetic.\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275304227012,"sku":null,"price":80.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/1ed2f0b25a80761cd83dd529f55520a5a277c667449cfe4b0b25a230c05cf25b_2.avif?v=1781951945"},{"product_id":"adrenal-60-s-60ct","title":"Adrenal 60's 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eAdrenal is a supplement designed to provide support to your adrenal glands and promote proper gland function.\u003cbr\u003e* Maintains adrenal gland function\u003cbr\u003e* Supports healthy cortisol levels\u003cbr\u003e* Whole adrenal and adrenal cortex are sourced from pasture-fed, pesticide-free bovine herds\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis formula offers a blend of whole adrenal and adrenal cortex. Whole adrenal and adrenal cortex are included for their potential to nutritionally support the adrenal gland.1\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Natural Medicines Comprehensive Database. Adrenal Extract Entry.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eWhole adrenal and adrenal cortex are sourced from pasture-fed, pesticide-free bovine herds. The extracts are freeze-dried and vacuum-dried\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275305406660,"sku":null,"price":21.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dad25765225911d1cad1a51e982070ee4e31d23c44743bba51d984070d8b4161.avif?v=1781953928"},{"product_id":"ashwagandha-60ct","title":"Ashwagandha 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps to counteract the effects of occasional stress\u003cbr\u003e* May support cardiovascular, immune, cognitive and joint function\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional stress\u003cbr\u003e* Overall physical and mental well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eAshwagandha is one of the most revered and widely used Ayurvedic herbs. Withanolides are key constituents of this herb and play an important role in its physical and mental health benefits.1, 2 In animal studies, ashwagandha has been shown to support the activity of lymphocytes and macrophages, moderate occasional stress, enhance memory and provide neuroprotection by scavenging free radicals and support thyroid function.3, 4, 5 A small human clinical trial demonstrated the ability of ashwagandha to support healthy glucose and lipid metabolism.6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Wankhede S, et al. *J Int Soc Sports Nutr.* 2015 Nov 25;12:43.\u003cbr\u003e2. Auddy B, et al. *JANA*. 2008 11(1): 50-6.\u003cbr\u003e3. Mikolai J, et al. *J Altern Complement Med.* 2009 Apr;15(4):423-30.\u003cbr\u003e4. Chandrasekhar K, et al. *Indian J Psychol Med.* 2012 Jul-Sep; 34(3): 255â€\"262.\u003cbr\u003e5. Bhattacharya SK\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eet al. *Phytomedicine.* 2000 Dec;7(6):463-9.\u003cbr\u003e6. Andallu B\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eet al. *Indian J Exp Biol.* 2000 Jun;38(6):607-9.,Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003econsult your health professional before use.,Store in a cool\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275305472196,"sku":null,"price":29.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/459fc61e0a842d888edc2011d16429856f3d277cf22d2a624f225ae716f3a3ef.avif?v=1781954078"},{"product_id":"ashwagandha-120ct","title":"Ashwagandha 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps to counteract the effects of occasional stress\u003cbr\u003e* May support cardiovascular, immune, cognitive and joint function\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional stress\u003cbr\u003e* Overall physical and mental well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eAshwagandha is one of the most revered and widely used Ayurvedic herbs. Withanolides are key constituents of this herb and play an important role in its physical and mental health benefits.1, 2 In animal studies, ashwagandha has been shown to support the activity of lymphocytes and macrophages, moderate occasional stress, enhance memory and provide neuroprotection by scavenging free radicals and support thyroid function.3, 4, 5 A small human clinical trial demonstrated the ability of ashwagandha to support healthy glucose and lipid metabolism.6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Wankhede S, et al. *J Int Soc Sports Nutr.* 2015 Nov 25;12:43.\u003cbr\u003e2. Auddy B, et al. *JANA*. 2008 11(1): 50-6.\u003cbr\u003e3. Mikolai J, et al. *J Altern Complement Med.* 2009 Apr;15(4):423-30.\u003cbr\u003e4. Chandrasekhar K, et al. *Indian J Psychol Med.* 2012 Jul-Sep; 34(3): 255â€\"262.\u003cbr\u003e5. Bhattacharya SK\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eet al. *Phytomedicine.* 2000 Dec;7(6):463-9.\u003cbr\u003e6. Andallu B\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eet al. *Indian J Exp Biol.* 2000 Jun;38(6):607-9.,Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003econsult your health professional before use.,Store in a cool\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275305504964,"sku":null,"price":52.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/459fc61e0a842d888edc2011d16429856f3d277cf22d2a624f225ae716f3a3ef_1.avif?v=1781954136"},{"product_id":"daily-stress-formula-90ct","title":"Daily Stress Formula‡ 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e\n* Supports the body's resilience when faced with occasional stress^‡^\u003cbr\u003e\n* Supports cognitive function^‡^\u003cbr\u003e\n* Helps moderate mild fatigue under stressful conditions^‡^\u003cbr\u003e\n* Chamomile and lemon balm promote calmness and relaxation^‡^\u003cbr\u003e\n* Supports energy metabolism and immune defense^‡^\u003cbr\u003e\n* Blend of botanicals, herbs and other nutrients\u003cbr\u003e\n* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e\nAs a dietary supplement, take 3 capsules daily, with or between meals.\u003c\/p\u003e\n\n\u003cp\u003eIndications:\u003cbr\u003e\n* Ages 18 and up\u003cbr\u003e\n* Occasional stress support^‡^\u003cbr\u003e\n* Relaxation support^‡^\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e\nIn addition to promoting memory and cognitive function, preclinical investigation shows *Bacopa monnieri* maintains healthy enzyme activity in the brain^1^ , supporting the ability to deal with stress.^2^ A double-blind crossover trial suggested that rhodiola may help to moderate mild fatigue under stressful conditions.^3^ In a separate, double-blind, placebo-controlled pilot study, rhodiola provided support for physical and mental stress in students.^4^ Similarly, the amino acid l-tyrosine has indicated the potential to promote cognitive function and memory under stressful conditions.^5^ *Eleutherococcus senticosus* , or eleuthero, is used as an adaptogen to help bolster adrenal function and stress resistance. Like ashwagandha, it is highly revered for promoting energy, vitality and immune defense.^6^ Chamomile and lemon balm provide traditional support for calmness and relaxation.^7, 8^ B vitamins and magnesium are included to help counter the effects of stress on healthy nutritional status.^9^ B-complex vitamins have also been associated with healthy neurotransmitter function and energy metabolism.^10^ Vitamin B^5^ is especially important for boosting healthy adrenal gland function to strengthen the body's ability to withstand stress.^11^ Vitamin C provides important support for neutralizing free radicals generated by the stress response.^12‡^\u003c\/p\u003e\n\n\u003cp\u003eReferences:\u003cbr\u003e\n1. Roodenrys S, et al. *Neuropsychopharmacology.*2002 Aug;27(2):279-81.\u003cbr\u003e\n2. Calabrese C, et al.*J Altern Complement Med.*2008 Jul;14(6):707-13.\u003cbr\u003e\n3. Darbinyan V, et al. *Phytomedicine.*2000 Oct;7(5):365-71.\u003cbr\u003e\n4. Spasov AA, et al.*Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e\n5. Steenbergen L, et al. *Neuropsychologia.* 2015 Mar;69:50-5.\u003cbr\u003e\n6. Kuo J, et al.*Chin J Physiol.* 2010 Apr 30;53(2):105-11.\u003cbr\u003e\n7. Amsterdam JD, et al.*J Clin Psychopharmacol.* 2009 Aug;29(4):378-82.\u003cbr\u003e\n8. Kennedy DO, et al.*Psychosom Med.* 2004 Jul-Aug;66(4):607-13.\u003cbr\u003e\n9. Stough C, et al.*Hum Psychopharmacol.* 2011 Oct;26(7):470-6.\u003cbr\u003e\n10. Stough C, et al. *Hum Psychopharmacol.*2011 Oct;26(7):470-6.\u003cbr\u003e\n11. Bean WB, et al. *J Clin Invest.* 1955 Jul; 34(7 Pt 1): 1073-84.\u003cbr\u003e\n12. Clarkson PM, et al. *Am J Clin Nutr.*2000 Aug;72(2 Suppl):637S-46S.\u003c\/p\u003e\n\n\u003cp\u003eWarning:\u003cbr\u003e\nNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\n\u003cp\u003eStorage:\u003cbr\u003e\nStore in a cool, dry place.\u003c\/p\u003e\n\n\u003cp\u003eSource:\u003cbr\u003e\n* Ascorbic acid, riboflavin (B~2~ ) and methylcobalamin (B~12~ ) are derived from corn dextrose fermentation\u003cbr\u003e\n* Thiamine HCl (B~1~ ), niacinamide, pantothenic acid (calcium pantothenate) (B~5~) and pyridoxine HCl (B~6~ ) are synthetically derived\u003cbr\u003e\n* Magnesium is derived from the lime of rock\u003cbr\u003e\n* l-Tyrosine (free-form) is derived from soy\u003cbr\u003e\n* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutheroside E \u0026amp; B\u003cbr\u003e\n* *Bacopa monniera* extract is derived from the leaf and standardized to contain 20% bacosides\u003cbr\u003e\n* *Rhodiola rosea* extract is derived from the root and standardized to contain 3% total rosavins and a minimum of 1% salidrosides\u003cbr\u003e\n* Chamomile is derived from *Matricaria recutita* flowers\u003cbr\u003e\n* Lemon balm is derived from *Melissa officinalis* leaves and standardized to contain 5% rosemarinic acid\u003cbr\u003e\n* Ashwagandha extract is derived from the root of *Withania somnifera* and standardized to contain 5% withanolides\u003cbr\u003e\n* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e\n* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275323429060,"sku":null,"price":41.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dsf1-1.avif?v=1781965252"},{"product_id":"daily-stress-formula-180ct","title":"Daily Stress Formula‡ 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports the body's resilience when faced with occasional stress\u003cbr\u003e* Supports cognitive function\u003cbr\u003e* Helps moderate mild fatigue under stressful conditions\u003cbr\u003e* Chamomile and lemon balm promote calmness and relaxation\u003cbr\u003e* Supports energy metabolism and immune defense\u003cbr\u003e* Blend of botanicals, herbs and other nutrients\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 3 capsules daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional stress support\u003cbr\u003e* Relaxation support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eIn addition to promoting memory and cognitive function, preclinical investigation shows *Bacopa monnieri* maintains healthy enzyme activity in the brain1 , supporting the ability to deal with stress.2 A double-blind crossover trial suggested that rhodiola may help to moderate mild fatigue under stressful conditions.3 In a separate, double-blind, placebo-controlled pilot study, rhodiola provided support for physical and mental stress in students.4 Similarly, the amino acid l-tyrosine has indicated the potential to promote cognitive function and memory under stressful conditions.5 *Eleutherococcus senticosus* , or eleuthero, is used as an adaptogen to help bolster adrenal function and stress resistance. Like ashwagandha, it is highly revered for promoting energy, vitality and immune defense.6 Chamomile and lemon balm provide traditional support for calmness and relaxation.7, 8 B vitamins and magnesium are included to help counter the effects of stress on healthy nutritional status.9 B-complex vitamins have also been associated with healthy neurotransmitter function and energy metabolism.10 Vitamin B5 is especially important for boosting healthy adrenal gland function to strengthen the body's ability to withstand stress.11 Vitamin C provides important support for neutralizing free radicals generated by the stress response.12\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Roodenrys S, et al. *Neuropsychopharmacology.*2002 Aug;27(2):279-81.\u003cbr\u003e2. Calabrese C, et al.*J Altern Complement Med.*2008 Jul;14(6):707-13.\u003cbr\u003e3. Darbinyan V, et al. *Phytomedicine.*2000 Oct;7(5):365-71.\u003cbr\u003e4. Spasov AA, et al.*Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e5. Steenbergen L, et al. *Neuropsychologia.* 2015 Mar;69:50-5.\u003cbr\u003e6. Kuo J, et al.*Chin J Physiol.* 2010 Apr 30;53(2):105-11.\u003cbr\u003e7. Amsterdam JD, et al.*J Clin Psychopharmacol.* 2009 Aug;29(4):378-82.\u003cbr\u003e8. Kennedy DO, et al.*Psychosom Med.* 2004 Jul-Aug;66(4):607-13.\u003cbr\u003e9. Stough C, et al.*Hum Psychopharmacol.* 2011 Oct;26(7):470-6.\u003cbr\u003e10. Stough C, et al. *Hum Psychopharmacol.*2011 Oct;26(7):470-6.\u003cbr\u003e11. Bean WB, et al. *J Clin Invest.* 1955 Jul; 34(7 Pt 1): 1073-84.\u003cbr\u003e12. Clarkson PM, et al. *Am J Clin Nutr.*2000 Aug;72(2 Suppl):637S-46S.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ascorbic acid, riboflavin (B2 ) and methylcobalamin (B12 ) are derived from corn dextrose fermentation\u003cbr\u003e* Thiamine HCl (B1), niacinamide, pantothenic acid (calcium pantothenate) (B5) and pyridoxine HCl (B6 ) are synthetically derived\u003cbr\u003e* Magnesium is derived from the lime of rock\u003cbr\u003e* l-Tyrosine (free-form) is derived from soy\u003cbr\u003e* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutheroside E \u0026amp; B\u003cbr\u003e* *Bacopa monniera* extract is derived from the leaf and standardized to contain 20% bacosides\u003cbr\u003e* *Rhodiola rosea* extract is derived from the root and standardized to contain 3% total rosavins and a minimum of 1% salidrosides\u003cbr\u003e* Chamomile is derived from *Matricaria recutita* flowers\u003cbr\u003e* Lemon balm is derived from *Melissa officinalis* leaves and standardized to contain 5% rosemarinic acid\u003cbr\u003e* Ashwagandha extract is derived from the root of *Withania somnifera* and standardized to contain 5% withanolides\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275323461828,"sku":null,"price":74.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/dsf1-1_1.avif?v=1781966666"},{"product_id":"emotional-wellness-60ct","title":"Emotional Wellness 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes positive mood and healthy emotional outlook\u003cbr\u003e* Supports cognitive function and memory under stressful conditions\u003cbr\u003e* Promotes relaxation and healthy sleep\/wake cycles\u003cbr\u003e* A blend of amino acids, herbs and vitamin cofactors\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional and mental well-being\u003cbr\u003e* Support for occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eEmotional Wellness combines amino acids, herbs and vitamin cofactors to promote healthy emotional well-being and cognitive function while moderating occasional stress. 5-hydroxytryptophan and l-tyrosine are key precursors for the synthesis of several neurotransmitters responsible for a healthy emotional outlook, including serotonin, dopamine, epinephrine and norepinephrine. These neurotransmitters are involved in the regulation of endocrine and brain activity in addition to sleep\/wake cycles.1 Research suggests that l-tyrosine may also support cognitive function and memory under stressful conditions.2 A healthy level of the inhibitory neurotransmitter GABA is also associated with positive mood.3 Research suggests that both GABA and l-theanine enhance alpha wave production in the brain, promoting relaxation.4, 5 Complementary support for relaxation is provided by passionflower, while Rhodiola rosea supports cognitive and mental function under stressful conditions.6, 7 Vitamin B6 is a cofactor that plays an important role in supporting positive emotional health.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Banderet LE, Lieberman HR. *Brain Res Bull.* 1989 Apr;22(4):759-62.\u003cbr\u003e2. Thomas JR, et al. *Pharmacol Biochem Behav.* 1999 Nov;64(3):495-500.\u003cbr\u003e3. Sanacora G, et al. *Arch Gen Psychiatry.* 2004 Jul;61(7):705-13.\u003cbr\u003e4. Abdou AM, et al.*Biofactors.* 2006;26(3):201-8.\u003cbr\u003e5. Song CH, et al. *Korean J Nutr.* 2003 Nov;36(9):918-923.\u003cbr\u003e6. Movafegh A, et al.*Anesth Analg.* 2008 Jun;106(6):1728-32. doi: 10.1213\/ane.0b013e318172c3f9.\u003cbr\u003e7. Spasov AA, et al.*Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e8. Wyatt KM, et al.*BMJ.* 1999 May 22; 318(7195): 1375â€\"1381.,Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eparticularly psychiatric medications\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003econsult your health professional before use. Do not use concurrently with antidepressants.,Store in a cool\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003edry place.,* Pyridoxal 5'phosphate (activated B6 )\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275324346564,"sku":null,"price":89.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/79e8750220a1ee870960430976612dd285b78c33cee8fca9c5b6afc4253ffcfc.avif?v=1781968032"},{"product_id":"emotional-wellness-120ct","title":"Emotional Wellness 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes positive mood and healthy emotional outlook\u003cbr\u003e* Supports cognitive function and memory under stressful conditions\u003cbr\u003e* Promotes relaxation and healthy sleep\/wake cycles\u003cbr\u003e* A blend of amino acids, herbs and vitamin cofactors\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional and mental well-being\u003cbr\u003e* Support for occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eEmotional Wellness combines amino acids, herbs and vitamin cofactors to promote healthy emotional well-being and cognitive function while moderating occasional stress. 5-hydroxytryptophan and l-tyrosine are key precursors for the synthesis of several neurotransmitters responsible for a healthy emotional outlook, including serotonin, dopamine, epinephrine and norepinephrine. These neurotransmitters are involved in the regulation of endocrine and brain activity in addition to sleep\/wake cycles.1 Research suggests that l-tyrosine may also support cognitive function and memory under stressful conditions.2 A healthy level of the inhibitory neurotransmitter GABA is also associated with positive mood.3 Research suggests that both GABA and l-theanine enhance alpha wave production in the brain, promoting relaxation.4, 5 Complementary support for relaxation is provided by passionflower, while Rhodiola rosea supports cognitive and mental function under stressful conditions.6, 7 Vitamin B6 is a cofactor that plays an important role in supporting positive emotional health.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Banderet LE, Lieberman HR. *Brain Res Bull.* 1989 Apr;22(4):759-62.\u003cbr\u003e2. Thomas JR, et al. *Pharmacol Biochem Behav.* 1999 Nov;64(3):495-500.\u003cbr\u003e3. Sanacora G, et al. *Arch Gen Psychiatry.* 2004 Jul;61(7):705-13.\u003cbr\u003e4. Abdou AM, et al.*Biofactors.* 2006;26(3):201-8.\u003cbr\u003e5. Song CH, et al. *Korean J Nutr.* 2003 Nov;36(9):918-923.\u003cbr\u003e6. Movafegh A, et al.*Anesth Analg.* 2008 Jun;106(6):1728-32. doi: 10.1213\/ane.0b013e318172c3f9.\u003cbr\u003e7. Spasov AA, et al.*Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e8. Wyatt KM, et al.*BMJ.* 1999 May 22; 318(7195): 1375â€\"1381.,Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eparticularly psychiatric medications\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003econsult your health professional before use. Do not use concurrently with antidepressants.,Store in a cool\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003edry place.,* Pyridoxal 5'phosphate (activated B6 )\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275324379332,"sku":null,"price":155.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/79e8750220a1ee870960430976612dd285b78c33cee8fca9c5b6afc4253ffcfc_3.avif?v=1781968125"},{"product_id":"gaba-60ct","title":"GABA 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e\n* Helps moderate occasional stress‡\u003cbr\u003e\n* Regulates cell-to-cell communication‡\u003cbr\u003e\n* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e\nAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eIndications:\u003cbr\u003e\n* Ages 18 and up\u003cbr\u003e\n* Supports relaxation and moderates occasional stress‡\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e\nGABA is the primary inhibitory neurotransmitter in the central nervous system, playing a central role in regulating cell-to-cell communication.^1^ Healthy levels have been associated with positive mood.^2^ A recent study indicates that GABA also enhances alpha wave production in the brain to promote relaxation and moderate occasional stress. In the same study, it supported healthy IgA levels, suggesting that it may support immune health during occasional stress.^3‡^\u003c\/p\u003e\n\n\u003cp\u003eReferences:\u003cbr\u003e\n1. Yoto A, et al. *Amino Acids.* 2012 Sep;43(3):1331-7.\u003cbr\u003e\n2. Nakamura H, et al. *Int J Food Sci Nutr.* 2009;60 Suppl 5:106-13.\u003cbr\u003e\n3. Abdou AM, et al. *Biofactors.* 2006;26(3):201-8.\u003c\/p\u003e\n\n\u003cp\u003eWarning:\u003cbr\u003e\nIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\n\u003cp\u003eStorage:\u003cbr\u003e\nStore in a cool, dry place.\u003c\/p\u003e\n\n\u003cp\u003eSource:\u003cbr\u003e\n* GABA (gamma-aminobutyric acid) is synthetic\u003cbr\u003e\n* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275328803012,"sku":null,"price":22.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/5423ab4a5b82bc072c2e84d0284d5b8f7a947dfa53d69c66ee5ab9fd05c5e898.avif?v=1781968933"},{"product_id":"gaba-120ct","title":"GABA 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps moderate occasional stress\u003cbr\u003e* Regulates cell-to-cell communication\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Supports relaxation and moderates occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eGABA is the primary inhibitory neurotransmitter in the central nervous system, playing a central role in regulating cell-to-cell communication.1 Healthy levels have been associated with positive mood.2 A recent study indicates that GABA also enhances alpha wave production in the brain to promote relaxation and moderate occasional stress. In the same study, it supported healthy IgA levels, suggesting that it may support immune health during occasional stress.3\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Yoto A, et al. *Amino Acids.* 2012 Sep;43(3):1331-7.\u003cbr\u003e2. Nakamura H, et al. *Int J Food Sci Nutr.* 2009;60 Suppl 5:106-13.\u003cbr\u003e3. Abdou AM, et al. *Biofactors.* 2006;26(3):201-8.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* GABA (gamma-aminobutyric acid) is synthetic\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275329786052,"sku":null,"price":38.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/5423ab4a5b82bc072c2e84d0284d5b8f7a947dfa53d69c66ee5ab9fd05c5e898_2.avif?v=1781969074"},{"product_id":"5-htp-5-hydroxytryptophan-100-mg-60ct","title":"5-HTP (5-Hydroxytryptophan) 100 mg 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e\n* Supports serotonin production \u0026amp; levels^‡^\u003cbr\u003e\n* May improve emotional well-being, appetite control and sleep\/wake cycles^‡^\u003cbr\u003e\n* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e\n* Small capsules for easy swallowing^‡^\u003cbr\u003e\n* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e\n5-HTP 50 mg\u003c\/p\u003e\n\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, before meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003e5-HTP 100 mg\u003c\/p\u003e\n\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, before meals.\u003c\/p\u003e\n\n\u003cp\u003eIndications:\u003cbr\u003e\n* Ages 18 and up\u003cbr\u003e\n* Brain serotonin levels to support emotional well-being^‡^\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e\n5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme.^1^ Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep\/wake cycles.^2, 3^ In clinical studies, administration of 5-HTP supported serotonin production.^4^ The 5-HTP supplied in this supplement is derived from the *Griffonia simplicifolia* plant.^‡^\u003c\/p\u003e\n\n\u003cp\u003eReferences:\u003cbr\u003e\n1. Turner EH, et al. *Pharmacol Ther.* 2006 Mar;109(3):325-38.\u003cbr\u003e\n2. Bruni O, et al. *Eur J Pediatr.* 2004 Jul;163(7):402-7.\u003cbr\u003e\n3. Rondanelli M, et al. *Eat Weight Disord.* 2012 Mar;17(1):e22-8.\u003cbr\u003e\n4. Croonenberghs J, et al. *Life Sci.* 2005 Mar 25;76(19):2171-83.\u003c\/p\u003e\n\n\u003cp\u003eWarning:\u003cbr\u003e\nNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, antidepressants or other psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\n\u003cp\u003eStorage:\u003cbr\u003e\nStore in a cool, dry place.\u003c\/p\u003e\n\n\u003cp\u003eSource:\u003cbr\u003e\n* 5-HTP is derived from the *Griffonia simplicifolia* plant\u003cbr\u003e\n* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275337126084,"sku":null,"price":61.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/984c889a8e65746c34d9ea9673076f3be5afc1d69116ab22b6cc3a1d3a0f11be.avif?v=1781974998"},{"product_id":"5-htp-5-hydroxytryptophan-100-mg-180ct","title":"5-HTP (5-Hydroxytryptophan) 100 mg 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports serotonin production \u0026amp; levels\u003cbr\u003e* May improve emotional well-being, appetite control and sleep\/wake cycles\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Small capsules for easy swallowing\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e5-HTP 50 mg\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, before meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003e5-HTP 100 mg\u003c\/p\u003e\n\u003cp\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, before meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Brain serotonin levels to support emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme.1 Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep\/wake cycles.2, 3 In clinical studies, administration of 5-HTP supported serotonin production.4 The 5-HTP supplied in this supplement is derived from the *Griffonia simplicifolia* plant.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Turner EH, et al. *Pharmacol Ther.* 2006 Mar;109(3):325-38.\u003cbr\u003e2. Bruni O, et al. *Eur J Pediatr.* 2004 Jul;163(7):402-7.\u003cbr\u003e3. Rondanelli M, et al. *Eat Weight Disord.* 2012 Mar;17(1):e22-8.\u003cbr\u003e4. Croonenberghs J, et al. *Life Sci.* 2005 Mar 25;76(19):2171-83.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, antidepressants or other psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* 5-HTP is derived from the *Griffonia simplicifolia* plant\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275337158852,"sku":null,"price":153.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/984c889a8e65746c34d9ea9673076f3be5afc1d69116ab22b6cc3a1d3a0f11be_1.avif?v=1781975110"},{"product_id":"5-htp-5-hydroxytryptophan-50-mg-60ct","title":"5-HTP (5-Hydroxytryptophan) 50 mg 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports serotonin production \u0026amp; levels\u003cbr\u003e* May improve emotional well-being, appetite control and sleep\/wake cycles\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Small capsules for easy swallowing\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e5-HTP 50 mg\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, before meals, or as directed by a health professional.\u003cbr\u003e5-HTP 100 mg\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, before meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Brain serotonin levels to support emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVerifiable Science\u003cbr\u003e5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme.1 Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep\/wake cycles.2, 3 In clinical studies, administration of 5-HTP supported serotonin production.4 The 5-HTP supplied in this supplement is derived from the *Griffonia simplicifolia* plant.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Turner EH, et al. *Pharmacol Ther.* 2006 Mar;109(3):325-38.\u003cbr\u003e2. Bruni O, et al. *Eur J Pediatr.* 2004 Jul;163(7):402-7.\u003cbr\u003e3. Rondanelli M, et al. *Eat Weight Disord.* 2012 Mar;17(1):e22-8.\u003cbr\u003e4. Croonenberghs J, et al. *Life Sci.* 2005 Mar 25;76(19):2171-83.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, antidepressants or other psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e5-HTP is derived from the *Griffonia simplicifolia* plant\u003cbr\u003eHypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275337191620,"sku":null,"price":42.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/012ccf94821124b820a9f996abf2ed62ee2d6d19990a7cc573cb2dc4cbea7b52.avif?v=1781975213"},{"product_id":"5-htp-5-hydroxytryptophan-50-mg-180ct","title":"5-HTP (5-Hydroxytryptophan) 50 mg 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports serotonin production \u0026amp; levels\u003cbr\u003e* May improve emotional well-being, appetite control and sleep\/wake cycles\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Small capsules for easy swallowing\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e5-HTP 50 mg\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, before meals, or as directed by a health professional.\u003cbr\u003e5-HTP 100 mg\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-3 times daily, before meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Brain serotonin levels to support emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eVerifiable Science\u003cbr\u003e5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme.1 Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep\/wake cycles.2, 3 In clinical studies, administration of 5-HTP supported serotonin production.4 The 5-HTP supplied in this supplement is derived from the *Griffonia simplicifolia* plant.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Turner EH, et al. *Pharmacol Ther.* 2006 Mar;109(3):325-38.\u003cbr\u003e2. Bruni O, et al. *Eur J Pediatr.* 2004 Jul;163(7):402-7.\u003cbr\u003e3. Rondanelli M, et al. *Eat Weight Disord.* 2012 Mar;17(1):e22-8.\u003cbr\u003e4. Croonenberghs J, et al. *Life Sci.* 2005 Mar 25;76(19):2171-83.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, antidepressants or other psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e5-HTP is derived from the *Griffonia simplicifolia* plant\u003cbr\u003eHypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275337224388,"sku":null,"price":105.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/012ccf94821124b820a9f996abf2ed62ee2d6d19990a7cc573cb2dc4cbea7b52_1.avif?v=1781975292"},{"product_id":"inositol-powder-8-8oz","title":"Inositol (powder) 8.8oz","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eMay support healthy mood, emotional wellness and behavior\u003cbr\u003eHelps lessen occasional nervous tension\u003cbr\u003eMay support healthy ovulatory activity, ovarian function and reproductive system function\u003cbr\u003eConvenient powder formula for easy dispensing\u003cbr\u003eMade with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 scoop, 1-2 times daily, mixed with water, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eEmotional wellness and ovarian health support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eInositol is a component of the B-complex family. Myo-inositol is the primary form of inositol found in the central nervous system. It plays an important role in cell membrane formation and serves as part of the phosphatidyl inositol secondary messenger system, supporting serotonin, norepinenephrine and cholinergic receptor function.1 As a result, inositol may support healthy mood, emotional wellness and behavior, and help lessen occasional nervous tension.2 Research also suggests that myo-inositol may help to support healthy ovulatory activity, ovarian function and reproductive system function.3, 4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Lucas CT, Call FL 2nd, Williams WJ. *J Clin Invest.*1970 Oct;49(10):1949-55.\u003cbr\u003e2. Carlomagno G, et al. *Hum Psychopharmacol*.2011 Oct;26(7):526-30.\u003cbr\u003e3. Gerli S, et al. *Gynecol Endocrinol.* 2007 Dec;23(12):700-3.\u003cbr\u003e4. Papaleo E, et al. *Fertil Steril.*2009 May;91(5):1750-4.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eMyo-inositol is derived from phytic acid from corn soaking water.\u003cbr\u003eAscorbyl palmitate is derived from corn dextrose fermentation and palm oil.\u003cbr\u003eHypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275337355460,"sku":null,"price":54.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/590de13b4c6c867e022fa88662b2d701fd00563ad1cb237f62da7ce441025b31.avif?v=1781975578"},{"product_id":"lithium-orotate-5-mg-90ct","title":"Lithium (orotate) 5 mg 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports mood, emotional wellness and behavioral health\u003cbr\u003e* Supports cognitive function\u003cbr\u003e* Promotes neurotransmitter activity\u003cbr\u003e* Combination of lithium and N-acetyl-l-cysteine (NAC)\u003cbr\u003e* Part of the PureSYNAPSE™ product line\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional wellness and mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLithium is an essential micronutrient with some chemical properties similar to calcium and magnesium. It is present in all organs and tissues in the body's Lithium has a long history of clinical use for supporting healthy mood and behavior, possibly through dopamine- and serotonin-mediated mechanisms.1-3 Lithium supports neurotransmittersystems and signaling cascades involved in brain health and behavior.1, 3 Several studies suggest that lithium supports memory and mood.1, 4, 5 A 12-month, randomized, double-blind trial involving 45 individuals suggests that low-dose lithium supplementation promotes cognitive performance.6 In cultured neurons, lithium-enhanced gene expression of glutathione-S-transferase (GST), a detoxification enzyme with neuroprotective functions.7Lithium also has been shown to promote healthy brain-derived neurotrophic factor (BDNF) levels in animal models and humans.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. SzklarskaD, Rzymski P.*Biol Trace Elem* Res189, 18-27 (2019).\u003cbr\u003e2. Beaulieu JM, et al.*Proc Natl Acad Sci U S A.* 2004 Apr 6;101(14):5099-104.\u003cbr\u003e3. Schrauzer GN, et al.*Biol Trace Elem Res.* 1994 Jan;40(1):89-101.\u003cbr\u003e4. Nunes MA, et al.*Curr Alzheimer Res.* 2013 Jan;10(1):104-7.\u003cbr\u003e5. Forlenza OV, et al.*Br J Psychiatry.* 2011 May;198(5):351-6.\u003cbr\u003e6. Straten G.*Curr Alzheimer Res.* 2011 Dec;8(8):853-9.\u003cbr\u003e7. Shao L, et al.*Neuroscience.* 2008 Jan 24;151(2):518-24.\u003cbr\u003e8. Leyhe T, et al.*J Alzheimers Dis.* 2009;16(3):649-56.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Lithium is mined and refined\u003cbr\u003e* Orotate and N-acetyl-l-cysteine are synthetically derived\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275338502340,"sku":null,"price":27.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e8b3b8f7e4284b9a1e91620bd867c14cda83c4eea7ab75de104839c4fc16cdf7.avif?v=1782124320"},{"product_id":"lithium-orotate-5-mg-180ct","title":"Lithium (orotate) 5 mg 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports mood, emotional wellness and behavioral health\u003cbr\u003e* Supports cognitive function\u003cbr\u003e* Promotes neurotransmitter activity\u003cbr\u003e* Combination of lithium and N-acetyl-l-cysteine (NAC)\u003cbr\u003e* Part of the PureSYNAPSE™ product line\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional wellness and mood support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eLithium is an essential micronutrient with some chemical properties similar to calcium and magnesium. It is present in all organs and tissues in the body's Lithium has a long history of clinical use for supporting healthy mood and behavior, possibly through dopamine- and serotonin-mediated mechanisms.1-3 Lithium supports neurotransmittersystems and signaling cascades involved in brain health and behavior.1, 3 Several studies suggest that lithium supports memory and mood.1, 4, 5 A 12-month, randomized, double-blind trial involving 45 individuals suggests that low-dose lithium supplementation promotes cognitive performance.6 In cultured neurons, lithium-enhanced gene expression of glutathione-S-transferase (GST), a detoxification enzyme with neuroprotective functions.7 Lithium also has been shown to promote healthy brain-derived neurotrophic factor (BDNF) levels in animal models and humans.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. SzklarskaD, Rzymski P.*Biol Trace Elem* Res189, 18-27 (2019).\u003cbr\u003e2. Beaulieu JM, et al.*Proc Natl Acad Sci U S A.* 2004 Apr 6;101(14):5099-104.\u003cbr\u003e3. Schrauzer GN, et al.*Biol Trace Elem Res.* 1994 Jan;40(1):89-101.\u003cbr\u003e4. Nunes MA, et al.*Curr Alzheimer Res.* 2013 Jan;10(1):104-7.\u003cbr\u003e5. Forlenza OV, et al.*Br J Psychiatry.* 2011 May;198(5):351-6.\u003cbr\u003e6. Straten G.*Curr Alzheimer Res.* 2011 Dec;8(8):853-9.\u003cbr\u003e7. Shao L, et al.*Neuroscience.* 2008 Jan 24;151(2):518-24.\u003cbr\u003e8. Leyhe T, et al.*J Alzheimers Dis.* 2009;16(3):649-56.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Lithium is mined and refined\u003cbr\u003e* Orotate and N-acetyl-l-cysteine are synthetically derived\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275338535108,"sku":null,"price":47.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e8b3b8f7e4284b9a1e91620bd867c14cda83c4eea7ab75de104839c4fc16cdf7_1.avif?v=1782124374"},{"product_id":"dl-phenylalanine-90ct","title":"DL-Phenylalanine 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports emotional well-being\u003cbr\u003e* Promotes memory and learning\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 2-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Supports emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eDL-Phenylalanine is a combination of the well-tolerated essential amino acids, d-phenylalanine and l-phenylalanine. Together, these amino acids have been studied for their potential to promote mental functioning and to support positive mood.1 l-Phenylalanine is a precursor to l-tyrosine, which is converted to the catecholamine neurotransmitters norepinephrine, epinephrine, dopamine and tyramine.2 l-Tyrosine and its metabolites play a role in emotional well-being, memory and learning.3 d-Phenylalanine may promote the levels of certain endorphins, which play a role in maintaining muscle and joint comfort.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. GrevetEH, et al.*J Psychopharmacol.*2002 Mar;16(1):51-5.\u003cbr\u003e2. Burn JH, et al. *Br J Pharmacol Chemother.* 1960 Mar; 15(1): 47 5.\u003cbr\u003e3. Thomas JR, et al. *Pharmacol Biochem Behav.*1999 Nov;64(3):495-500.\u003cbr\u003e4. Kitade T, et al.*Acupunct Electrother Res.* 1990;15(2):121-35.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003ePHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* dl-Phenylalanine (free-form) is synthetically produced\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275339157700,"sku":null,"price":35.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/82fcf145bc204f70e66d9ee01591e3fc33f86d23a834f44c852bd2960e8f8255.avif?v=1782124696"},{"product_id":"dl-phenylalanine-180ct","title":"DL-Phenylalanine 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports emotional well-being\u003cbr\u003e* Promotes memory and learning\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 2-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Supports emotional well-being\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eDL-Phenylalanine is a combination of the well-tolerated essential amino acids, d-phenylalanine and l-phenylalanine. Together, these amino acids have been studied for their potential to promote mental functioning and to support positive mood.1 l-Phenylalanine is a precursor to l-tyrosine, which is converted to the catecholamine neurotransmitters norepinephrine, epinephrine, dopamine and tyramine.2 l-Tyrosine and its metabolites play a role in emotional well-being, memory and learning.3 d-Phenylalanine may promote the levels of certain endorphins, which play a role in maintaining muscle and joint comfort.4\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. GrevetEH, et al.*J Psychopharmacol.*2002 Mar;16(1):51-5.\u003cbr\u003e2. Burn JH, et al. *Br J Pharmacol Chemother.* 1960 Mar; 15(1): 47 5.\u003cbr\u003e3. Thomas JR, et al. *Pharmacol Biochem Behav.*1999 Nov;64(3):495-500.\u003cbr\u003e4. Kitade T, et al.*Acupunct Electrother Res.* 1990;15(2):121-35.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003ePHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* dl-Phenylalanine (free-form) is synthetically produced\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275339190468,"sku":null,"price":63.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/82fcf145bc204f70e66d9ee01591e3fc33f86d23a834f44c852bd2960e8f8255_1.avif?v=1782124760"},{"product_id":"l-tyrosine-90ct","title":"l-Tyrosine 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports dopamine synthesis for emotional wellness and cognitive function\u003cbr\u003e* Promotes healthy neurotransmitter function in response to stress\u003cbr\u003e* Supports mood\u003cbr\u003e* Supports thyroid hormone synthesis\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-4 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Emotional wellness and mood support\u003cbr\u003e* Thyroid support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eIn the body l-phenylalanine is converted to l-tyrosine.1 The amino acid l-tyrosine is a precursor of catecholamine neurotransmitters, including l-dopa, dopamine, epinephrine and norepinephrine.2 These neurotransmitters are responsible for supporting emotional well-being and mental function. l- Tyrosine plays a role in promoting healthy neurotransmitter function in response to environmental and emotional stress. Research has indicated its potential to further support cognitive function and memory under stressful conditions.3 In one study, l-tyrosine helped support mood in subjects with low dopamine levels.4 l-Tyrosine is also a key component in the synthesis of thyroid hormones.5\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Udenfriend S, et al. *J Biol Chem*. 1952Feb;194(2):503-11.\u003cbr\u003e2. Bloemendaal M, et al. *eNeuro*. 2018 Apr30;5(2):ENEURO.0035-17.2018.\u003cbr\u003e3. Steenbergen L, et al. *Neuropsychologia*. 2015Mar;69:50-5.\u003cbr\u003e4. Mouret J, et al. *C R Acad Sci III*. 1988;306(3):93-\u003cbr\u003e5. Maurizis JC, et al. *FEBS*. 1981. 132(1); 29-32.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003el-Tyrosine is extracted from protein and extensively processed and purified in a semisynthetic process\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275339845828,"sku":null,"price":34.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/78e430cea7e2f695ebc720916ea3dae1fc057c910f0d062726b7b4eb023a01ec_1.avif?v=1782125302"},{"product_id":"l-theanine-60ct","title":"l-Theanine 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes relaxation\u003cbr\u003e* Helps moderate occasional stress\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Promotes relaxation without causing drowsiness\u003cbr\u003e* Supports healthy cellular function\u003cbr\u003e* May help moderate the effects of caffeine on the central nervous system\u003cbr\u003e* May promote premenstrual support including healthy mood\u003cbr\u003e* The biologically active constituent of green tea\u003cbr\u003e* Contains clinically researched Suntheanine®\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, children ages 8-18, take 1 capsule, 1-2 times daily, between meals. Adults, take 2 capsules, 1-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Relaxation without drowsiness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eGreen tea has been recognized for centuries as having relaxant properties. l-Theanine, a unique amino acid derived from tea, provides the characteristic taste of green tea. l-Theanine also has also discovered as the biologically active constituent of green tea responsible for promoting relaxation. In a preliminary non-clinical study, an l-theanine solution enhanced alpha wave production in the occipital and parietal regions of the brains of volunteers. These observed patterns are considered to be an index of relaxation. Furthermore, it did so rapidly and without causing drowsiness.1 In two additional studies, alpha waves were also shown to be detectable soon after l-theanine administration.2, 3 l-Theanine also is useful for supporting healthy cellular function.4 Preliminary research suggests that l-theanine may be helpful for premenstrual support including healthy mood.5 Furthermore, l-theanine has been reported to moderate the effects of caffeine on the central nervous system.6 l-Theanine's safety is supported in studies and by its long history of safe consumption in tea. Pure Encapsulations's l-Theanine is Suntheanine® , the brand which has been used in scientific studies.7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Juneja LR, et al. *Trends in Food Science \u0026amp; Technology.*1999. 10; 199-204.\u003cbr\u003e2. Song CH, et al. *Korean J Nutr.* 2003 Nov;36(9):918-923.\u003cbr\u003e3. Kobayashi K, et al. *Nippon N'ei Kagakukaighi.* 1998:72(2):153-7.\u003cbr\u003e4. Kim TI, et al. *Free Radic Biol Med.*2009 Dec 1;47(11):1601-10.\u003cbr\u003e5. Timmcke JQ, et al. *FASEB J.* 2008. 22; 760.\u003cbr\u003e6. Giles GE, et al. *Can J Physiol Pharmacol.* 2017 Jan;95(1):93-100\u003cbr\u003e7. Lyon MR, et al. *Altern Med Rev.* 2011 Dec;16(4):348-54.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* l-Theanine is the most abundant free-form amino acid found in tea leaves. Suntheanine® l-Theanine is produced from enzymatic fermentation\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275339878596,"sku":null,"price":65.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/bc8714c51d3bb59ad4527adc928ae33456c1a78a5367f9f0b29f672a6c62f45b.avif?v=1782125360"},{"product_id":"l-theanine-120ct","title":"l-Theanine 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Promotes relaxation\u003cbr\u003e* Helps moderate occasional stress\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Promotes relaxation without causing drowsiness\u003cbr\u003e* Supports healthy cellular function\u003cbr\u003e* May help moderate the effects of caffeine on the central nervous system\u003cbr\u003e* May promote premenstrual support including healthy mood\u003cbr\u003e* The biologically active constituent of green tea\u003cbr\u003e* Contains clinically researched Suntheanine®\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, children ages 8-18, take 1 capsule, 1-2 times daily, between meals. Adults, take 2 capsules, 1-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Relaxation without drowsiness\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eGreen tea has been recognized for centuries as having relaxant properties. l-Theanine, a unique amino acid derived from tea, provides the characteristic taste of green tea. l-Theanine also has also discovered as the biologically active constituent of green tea responsible for promoting relaxation. In a preliminary non-clinical study, an l-theanine solution enhanced alpha wave production in the occipital and parietal regions of the brains of volunteers. These observed patterns are considered to be an index of relaxation. Furthermore, it did so rapidly and without causing drowsiness.1 In two additional studies, alpha waves were also shown to be detectable soon after l-theanine administration.2, 3 l-Theanine also is useful for supporting healthy cellular function.4 Preliminary research suggests that l-theanine may be helpful for premenstrual support including healthy mood.5 Furthermore, l-theanine has been reported to moderate the effects of caffeine on the central nervous system.6 l-Theanine's safety is supported in studies and by its long history of safe consumption in tea. Pure Encapsulations's l-Theanine is Suntheanine® , the brand which has been used in scientific studies.7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Juneja LR, et al. *Trends in Food Science \u0026amp; Technology.*1999. 10; 199-204.\u003cbr\u003e2. Song CH, et al. *Korean J Nutr.* 2003 Nov;36(9):918-923.\u003cbr\u003e3. Kobayashi K, et al. *Nippon N'ei Kagakukaighi.* 1998:72(2):153-7.\u003cbr\u003e4. Kim TI, et al. *Free Radic Biol Med.*2009 Dec 1;47(11):1601-10.\u003cbr\u003e5. Timmcke JQ, et al. *FASEB J.* 2008. 22; 760.\u003cbr\u003e6. Giles GE, et al. *Can J Physiol Pharmacol.* 2017 Jan;95(1):93-100\u003cbr\u003e7. Lyon MR, et al. *Altern Med Rev.* 2011 Dec;16(4):348-54.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* l-Theanine is the most abundant free-form amino acid found in tea leaves. Suntheanine® l-Theanine is produced from enzymatic fermentation\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275339911364,"sku":null,"price":115.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/bc8714c51d3bb59ad4527adc928ae33456c1a78a5367f9f0b29f672a6c62f45b_1.avif?v=1782125461"},{"product_id":"neuromood-pure-pack-30-pack","title":"NeuroMood Pure Pack 30 pack","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eSupport for healthy neurotransmitter function, positive mood and emotional wellness\u003cbr\u003ePromotes cognitive function and healthy eating behavior\u003cbr\u003eSupports relaxation\u003cbr\u003eVitamins and minerals in highly bioavailable forms\u003cbr\u003eActivated B vitamins, including Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate\u003cbr\u003eEasily tolerated magnesium glycinate for sensitive individuals\u003cbr\u003eConvenient, once-daily packet\u003cbr\u003eMade with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 packet daily (5 capsules), with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eEmotional wellness and positive mood support\u003cbr\u003eRelaxation support\u003cbr\u003eHealthy eating behavior support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eNeuroMood Pure Pack is designed to promote positive mood, neurotransmitter function, relaxation and healthy eating behavior with a comprehensive profile of bioavailable vitamins, chelated minerals, fish oil and other ingredients. B vitamins, chromium, taurine and curcumin promote neurotransmitter function. The B vitamins folate, vitamin B6 and vitamin B12 are critical for proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine and dopamine.1 Chromium supports serotonin receptor sensitivity, as well as memory and healthful patterns of carbohydrate and energy intake.2 Preclinical data suggest that taurine may moderate the effects of stress on mood.3 Curcumin promotes healthy levels of serotonin and dopamine.4 Curcu min also supports neuronal health and emotional balance through immunological mechanisms.5 Omega-3 essential fatty acids, folate, vitamin B6 , zinc and magnesium also play important roles in positive mood and relaxation.6 Omega-3 fatty acids may also moderate appetite by supporting healthy cholecystokinin (CCK) release.7 Optimal levels of zinc also help to maintain healthy eating behaviors, possibly by moderating appetite-stimulating hormones such as neuropeptide Y (NPY) and ghrelin.8‡\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Merete C, et al.J Am Coll Nutr. 2008 Jun; 27(3): 421-27.\u003cbr\u003e2. Docherty JP, et al. J Psychiatr Pract.2005 Sep;11(5):302-14.\u003cbr\u003e3. Wu GF, et al. Sci Rep.2017 Jul 10;7(1):4989.\u003cbr\u003e4. Kulkarni SK, et al. Psychopharmacology (Berl).2008 Dec;201(3):435-42.\u003cbr\u003e5. Ramaholimihaso T, et al. Front Psychiatry.2020 Nov 27;11:572533.\u003cbr\u003e6. Sinn N, et al. Br J Nutr.2012 Jun;107(11):1682-93.\u003cbr\u003e7. Harden CJ, et al. Br J Nutr.2012 Aug;108(4):755-8.\u003cbr\u003e8. Yin J, et al.J Nutr Biochem.2009 Oct;20(10):783-90.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.PHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275342270660,"sku":null,"price":78.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/088f3e2b54adc83f7793f2a69c6cac94708f62e4f6053684cd819eb507ab4046.avif?v=1782131570"},{"product_id":"neuropure-120ct","title":"NeuroPure 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eProvides enhanced support for emotional balance and mood stability\u003cbr\u003eSupports overall neurotransmitter function and neuronal health\u003cbr\u003eContains a blend of neurotransmitter precursors\u003cbr\u003ePart of the PureSYNAPSE™ product line\u003cbr\u003eMade with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eSupports emotional wellness and positive mood\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eNeuroPure promotes the production of serotonin and dopamine to support emotional balance and mood stability. This formula includes the serotonin and dopamine neurotransmitter precursors 5-HTP and DL-phenylalanine, together with the essential cofactors vitamin B6 , Metafolin® L-5-MTHF and zinc that support neurotransmitter production.1-3 Optimal zinc and folate status is associated with positive mood in studies.4, 5 Phenylalanine supports phenylethylamine (PEA) activity, which plays important roles in emotional wellness.6 Curcumin supports healthy serotonin receptor function and maintains cytokine balance.7 In preclinical models, quercetin moderates the activity of monoamine oxidase, potentially enhancing synaptic levels of monoamine neurotransmitters.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Emanuele E, et al. *Neuro Endocrinol Lett*.2010;31(5):663-6.\u003cbr\u003e2. Skarupski KA, etal. *Am J Clin Nutr*.2010 Aug;92(2):330-5.\u003cbr\u003e3. Maes M, et al. *Biol Psychiatry*.1997 Sep 1;42(5):349-58.\u003cbr\u003e4. Mashayekh A, et al. *Neuroradiology*. 2011 Mar;53(3):185-91.\u003cbr\u003e5. Vishwanathan R, et al. *Age Ageing*. 2014 Mar;43(2):271-5.\u003cbr\u003e6. Zhang L, et al. *J Alzheimers Dis*. 2006 Sep;10(1):1-7.\u003cbr\u003e7. Witte AV, et al. *J Neurosci*.2014 Jun 4;34(23):7862-70.\u003cbr\u003e8. Kennedy DO, et al. *Psychosom Med*.2004 Jul-Aug;66(4):607-13.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003ePHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003ePyridoxal 5'phosphate, folate (Metafolin® , L-5-MTHF) and DL-Phenylalanine are synthetic\u003cbr\u003eMagnesium and zinc are derived from the lime of rock\u003cbr\u003e5-Hydroxytryptophan is derived from *Griffonia simplicifolia* seeds\u003cbr\u003eTurmeric extractis derived from *Curcuma longa* root and standardized to contain 18% curcuminoids\u003cbr\u003ePhospholipids are derived from soy\u003cbr\u003eQuercetin is derived from the Fava d'anta tree (*Dimorphandra mollis* ) pods and Cat's claw (*Uncaria tormentosa*) leaves\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275342303428,"sku":null,"price":70.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/001d882a101d974203fc144b8df0cc83415567b8d223c93ab55e32c7272d33ae_1.avif?v=1782131641"},{"product_id":"panax-ginseng-120ct","title":"Panax Ginseng 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps the body mediate stress response\u003cbr\u003e* Promotes adrenal gland health\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Standardized to contain 12% ginsenosides\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2-3 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Support for occasional stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePanax ginseng has long been utilized to assist the body in adapting to physical and emotional stress. During prolonged exercise, Panax ginseng promotes endurance and stamina.1 Panax ginseng also encourages adrenal gland health in times of occasional stress by maintaining healthy levels of certain adrenal hormones, such as corticosterone.2 This versatile herb has shown potential support for testosterone and spermatozoa levels in animal studies, and may also support male reproductive health as demonstrated in several human studies.3-5\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Wang LC, et al. *Planta Med*. 1998 Mar;64(2):130-3.\u003cbr\u003e2. Hiai S, et al. *Endocrinol Jpn.* 1979 Dec;26(6):661-5.\u003cbr\u003e3. Sawiress FA, et al. *Endocr Regul.* 2011 Jul;45(3):139-48.\u003cbr\u003e4. Choi HK, et al. *Int J Impot Res*. 1995 Sep;7(3):181-6.\u003cbr\u003e5. de Andrade E, et al. *Asian J Androl.* 2007 Mar;9(2):241-4.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003ePanax ginseng is sourced from the root of the *Panax Ginseng C.A. Meyer*plant. It is standardized to contain 12% ginsenosides\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275343384772,"sku":null,"price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/9797f1b8c8dd2420275cf4cc19ceb0f718bec34dd5b7d612768f10015970a940.avif?v=1782136989"},{"product_id":"phyto-adr-60ct","title":"Phyto-ADR 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports the health and activity of the adrenal glands\u003cbr\u003e* Promotes physiological balance and moderating occasional emotional stress\u003cbr\u003e* Supports optimal energy reserves\u003cbr\u003e* Promotes immune function\u003cbr\u003e* May help to moderate mild fatigue under stressful conditions\u003cbr\u003e* Formulated with a blend of standardized botanicals\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Adrenal support\u003cbr\u003e* Occasional stress support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis vegetarian formula provides wide range herbal and nutritional support for the adrenal glands. Panax ginseng and *Eleutherococcus senticosus* , or eleuthero, are highly recognized adaptogens, promoting physiological balance and moderating occasional stress. In part, they help to moderate the production of adrenocorticotrophic hormone (ACTH) and ultimately corticosterone activity.1, 2 Corticosterone promotes the conversion of amino acids into carbohydrates and glycogen by the liver and stimulates glycogen formation in the tissues, supporting optimal energy reserves.3 *Rhodiola rosea* , containing rosavins and salidrosides, also acts to balance hypothalamic-pituitary-adrenal activity. Rhodiola can have a calming effect on the central nervous system and supports healthy adrenal gland function.4 In particular, rhodiola may moderate the effects of occasional physical and emotional stress.5 Recently, a double-blind, crossover study suggested that rhodiola may help to moderate mild fatigue under stressful conditions.6 Astragalus and ashwagandha promote immune function and complement the adaptogenic activity of this formula.7, 8 Pantothenate, also known as vitamin B5 , is essential for healthy adrenal function.9 Collectively, these ingredients support the health and activity of the adrenal glands.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Hiai S, et al. *Endocrinol Jpn.* 1979 Dec;26(6):661-5.\u003cbr\u003e2. Gaffney BT, et al. *Life Sci*. 2001 Dec 14;70(4):431-42.\u003cbr\u003e3. Mornagui B, et al. *Horm Metab Res.* 2011 Jun;43(6):369-73.\u003cbr\u003e4. Darbinyan V, et al. *Phytomedicine.* 2000 Oct;7(5):365-71.\u003cbr\u003e5. Bystritsky A, et al. *J Altern Complement Med.*2008 Mar;14(2):175-80.\u003cbr\u003e6. Olsson EM, et al. *Planta Med*. 2009 Feb;75(2):105-12.\u003cbr\u003e7. Huang ZQ, et al. *Zhongguo Zhong Xi Yi Jie He Za*Zhi. 1995 Jun;15(6):328-30.\u003cbr\u003e8. Mikolai J, et al. *J Altern Complement Med*. 2009 Apr;15(4):423-30.\u003cbr\u003e9. Tarasov IuA, et al. *Vopr Pitan*. 1985 Jul-Aug;(4):51-4.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Calcium pantothenate (vitamin B5) is synthetic\u003cbr\u003e* Panax ginseng extract is derived from the root and standardized to contain 5% total ginsenosides\u003cbr\u003e* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutheroside E \u0026amp; B\u003cbr\u003e* Ashwagandha extract is derived from *Withania* *somnifera* and standardized to contain 5% withanolides\u003cbr\u003e* *Rhodiola rosea* extract is derived from the root and standardized to contain 3% total rosavins and min. 1% salidrosides\u003cbr\u003e* *Astragalus membranaceus* extract (8:1) is derived from the root\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275343745220,"sku":null,"price":31.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/phy1-1.avif?v=1782137654"},{"product_id":"phyto-adr-180ct","title":"Phyto-ADR 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports the health and activity of the adrenal glands\u003cbr\u003e* Promotes physiological balance and moderating occasional emotional stress\u003cbr\u003e* Supports optimal energy reserves\u003cbr\u003e* Promotes immune function\u003cbr\u003e* May help to moderate mild fatigue under stressful conditions\u003cbr\u003e* Formulated with a blend of standardized botanicals\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Adrenal support\u003cbr\u003e* Occasional stress support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eThis vegetarian formula provides wide range herbal and nutritional support for the adrenal glands. Panax ginseng and *Eleutherococcus senticosus* , or eleuthero, are highly recognized adaptogens, promoting physiological balance and moderating occasional stress. In part, they help to moderate the production of adrenocorticotrophic hormone (ACTH) and ultimately corticosterone activity.1, 2 Corticosterone promotes the conversion of amino acids into carbohydrates and glycogen by the liver and stimulates glycogen formation in the tissues, supporting optimal energy reserves.3 *Rhodiola rosea* , containing rosavins and salidrosides, also acts to balance hypothalamic-pituitary-adrenal activity. Rhodiola can have a calming effect on the central nervous system and supports healthy adrenal gland function.4 In particular, rhodiola may moderate the effects of occasional physical and emotional stress.5 Recently, a double-blind, crossover study suggested that rhodiola may help to moderate mild fatigue under stressful conditions.6 Astragalus and ashwagandha promote immune function and complement the adaptogenic activity of this formula.7, 8 Pantothenate, also known as vitamin B5 , is essential for healthy adrenal function.9 Collectively, these ingredients support the health and activity of the adrenal glands.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Hiai S, et al. *Endocrinol Jpn.* 1979 Dec;26(6):661-5.\u003cbr\u003e2. Gaffney BT, et al. *Life Sci*. 2001 Dec 14;70(4):431-42.\u003cbr\u003e3. Mornagui B, et al. *Horm Metab Res.* 2011 Jun;43(6):369-73.\u003cbr\u003e4. Darbinyan V, et al. *Phytomedicine.* 2000 Oct;7(5):365-71.\u003cbr\u003e5. Bystritsky A, et al. *J Altern Complement Med.*2008 Mar;14(2):175-80.\u003cbr\u003e6. Olsson EM, et al. *Planta Med*. 2009 Feb;75(2):105-12.\u003cbr\u003e7. Huang ZQ, et al. *Zhongguo Zhong Xi Yi Jie He Za*Zhi. 1995 Jun;15(6):328-30.\u003cbr\u003e8. Mikolai J, et al. *J Altern Complement Med*. 2009 Apr;15(4):423-30.\u003cbr\u003e9. Tarasov IuA, et al. *Vopr Pitan*. 1985 Jul-Aug;(4):51-4.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Calcium pantothenate (vitamin B5 ) is synthetic\u003cbr\u003e* Panax ginseng extract is derived from the root and standardized to contain 5% total ginsenosides\u003cbr\u003e* *Eleutherococcus senticosus* extract is derived from the root and standardized to contain 0.8% eleutheroside E \u0026amp; B\u003cbr\u003e* Ashwagandha extract is derived from *Withania* *somnifera* and standardized to contain 5% withanolides\u003cbr\u003e* *Rhodiola rosea* extract is derived from the root and standardized to contain 3% total rosavins and min. 1% salidrosides\u003cbr\u003e* *Astragalus membranaceus* extract (8:1) is derived from the root\u003cbr\u003e* Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275343777988,"sku":null,"price":84.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/phy1-1_1.avif?v=1782137703"},{"product_id":"pure-tranquility-liquid-116-ml","title":"Pure Tranquility liquid 116 ml","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports relaxation without drowsiness\u003cbr\u003e* Helps moderate occasional stress while maintaining immune health\u003cbr\u003e* Maintains healthy IgA levels\u003cbr\u003e* Contains combination of GABA, glycine and l-theanine\u003cbr\u003e* Convenient, great-tasting liquid formula for easy dispensing\u003cbr\u003e* Made with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 4 ml (4 full droppers), 1-2 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Relaxation support\u003cbr\u003e* Occasional stress support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePure Tranquility liquid offers calming support with the main inhibitory neurotransmitters, GABA and glycine.1 Both GABA and l-theanine enhance alpha wave production in the brain to promote relaxation and moderate occasional stress. In an open trial, GABA promoted alpha waves and moderated beta waves within 1 hour of administration.2 Several studies indicate that l-theanine enhances alpha wave production in the occipital and parietal regions of the brain, an indicator of relaxation, without causing drowsiness.3, 4 Evidence suggests that GABA and l-theanine also maintain healthy IgA levels, potentially supporting immune health during occasional stress.5, 6\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Sanacora G, et al. *Arch Gen Psychiatry.* 2004Jul;61(7):705-13.\u003cbr\u003e2. Yoto A, et al. *A Acids.* 2012 Sep;43(3):1331-7.\u003cbr\u003e3. Nobre AC, et al. *Asia Pac J Clin Nutr.* 2008;17 Supl 1:167-8.\u003cbr\u003e4. Song CH, et al. *Korean J Nutr.* 2003 Nov;36(9):918-923.\u003cbr\u003e5. Abdou AM, et al. *Biofactors.* 2006;26(3):201-8.\u003cbr\u003e6. Kimura K, et al. *Biol Psychol.* 2007 Jan;74(1):39-45.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* GABA (gamma-aminobutyric acid) and glycine are synthetic\u003cbr\u003e* Suntheanine® l-Theanine is produced from enzymatic fermentation\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275345547460,"sku":null,"price":51.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/341ab94215d0c4c7d301200eebbb892b497987a5d633bafe5f27137390e288a1.avif?v=1782141845"},{"product_id":"relora-60ct","title":"Relora® 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps moderate occasional stress\u003cbr\u003e* Promotes relaxation\u003cbr\u003e* Helps support healthful eating habits and moderate appetite and snack cravings\u003cbr\u003e* Promotes emotional well-being\u003cbr\u003e* A proprietary blend of *Magnolia officinalis* and *Phellodendron amurense*\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional stress and muscle tension\u003cbr\u003e* Healthy eating behavior\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRelora® is a proprietary blend of *Magnolia officinalis* and *Phellodendron amurense* . This clinically studied combination of extracts supports positive mood and helps to moderate everyday stress. It also promotes healthy eating behavior and muscle relaxation.1 Certain magnolia and phellodendron constituents may bind to GABA receptors and serotonin transporters in the central nervous system, which encourage feelings of satiety and relaxation.2, 3 A pilot clinical trial reported that Relora® was well tolerated in promoting emotional well-being.4 A follow-up trial reported similar results, additionally showing that Relora® may help diminish stress related sugary snack cravings and promote healthful eating habits.5 An animal study further demonstrated the supplement's ability to support mood and relaxation.6 A recent pilot clinical trial performed in Cincinnati, Ohio, suggested that magnolia and phellodendron helped to maintain healthy cortisol and DHEA production and metabolism, which helped support healthy body fat distribution.7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kalman DS, et al. *Nutr J.* 2008 Apr 21;7:11.\u003cbr\u003e2. Garrison R, et al. *Altern Ther Health Med.* 2006 Jan-Feb;12(1):50-4.\u003cbr\u003e3. Chen CR, et al. *Neuropharmacology.* 2012 Nov;63(6):1191-9.\u003cbr\u003e4. Talbott SM, et al. *J Int Soc Sports Nutr.* 2013 Aug 7;10(1):37.\u003cbr\u003e5. Unpublished clinical trial on Relora® treating stressed-induced overeating.\u003cbr\u003e6. Sufka KJ, et al. *Psychopharmacology (Berl).* 2001 Jan 1;153(2):219-24.\u003cbr\u003e7. LaValle J, et al. *Living Longer Clinic*, Cincinnati, Ohio. 2001.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medication, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Relora® is a proprietary blend of *Magnolia officinalis* (bark) and *Phellodendron amurense* (bark). Relora® is a trademark of Next Pharmaceuticals, Inc. U.S. Patent No. 6, 582, 735\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275347022020,"sku":null,"price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/9732ff21a68c494cb854231055384fe85d9afdca966ab2cfdbedd181206b9482.avif?v=1782143358"},{"product_id":"relora-180ct","title":"Relora® 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps moderate occasional stress\u003cbr\u003e* Promotes relaxation\u003cbr\u003e* Helps support healthful eating habits and moderate appetite and snack cravings\u003cbr\u003e* Promotes emotional well-being\u003cbr\u003e* A proprietary blend of *Magnolia officinalis* and *Phellodendron amurense*\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 2 times daily, with or between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Occasional stress and muscle tension\u003cbr\u003e* Healthy eating behavior\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRelora^®^ is a proprietary blend of *Magnolia officinalis* and *Phellodendron amurense* . This clinically studied combination of extracts supports positive mood and helps to moderate everyday stress. It also promotes healthy eating behavior and muscle relaxation.1 Certain magnolia and phellodendron constituents may bind to GABA receptors and serotonin transporters in the central nervous system, which encourage feelings of satiety and relaxation.2, 3 A pilot clinical trial reported that Relora® was well tolerated in promoting emotional well-being.4 A follow-up trial reported similar results, additionally showing that Relora® may help diminish stress related sugary snack cravings and promote healthful eating habits.5 An animal study further demonstrated the supplement's ability to support mood and relaxation.6 A recent pilot clinical trial performed in Cincinnati, Ohio, suggested that magnolia and phellodendron helped to maintain healthy cortisol and DHEA production and metabolism, which helped support healthy body fat distribution.7\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Kalman DS, et al. *Nutr J.* 2008 Apr 21;7:11.\u003cbr\u003e2. Garrison R, et al. *Altern Ther Health Med.* 2006 Jan-Feb;12(1):50-4.\u003cbr\u003e3. Chen CR, et al. *Neuropharmacology.* 2012 Nov;63(6):1191-9.\u003cbr\u003e4. Talbott SM, et al. *J Int Soc Sports Nutr.* 2013 Aug 7;10(1):37.\u003cbr\u003e5. Unpublished clinical trial on Relora® treating stressed-induced overeating.\u003cbr\u003e6. Sufka KJ, et al. *Psychopharmacology (Berl).* 2001 Jan 1;153(2):219-24.\u003cbr\u003e7. LaValle J, et al. *Living Longer Clinic*, Cincinnati, Ohio. 2001.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medication, consult your health professional before use. Do not use concurrently with antidepressants.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Relora® is a proprietary blend of *Magnolia officinalis* (bark) and *Phellodendron amurense* (bark). Relora® is a trademark of Next Pharmaceuticals, Inc. U.S. Patent No. 6, 582, 735\u003cbr\u003e* Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275347153092,"sku":null,"price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/9732ff21a68c494cb854231055384fe85d9afdca966ab2cfdbedd181206b9482_1.avif?v=1782143459"},{"product_id":"rhodiola-rosea-90ct","title":"Rhodiola Rosea 90ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps moderate occasional mental and physical stress\u003cbr\u003e* Supports cardiovascular health\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Standardized to contain 3% total rosavins and 1% salidroside\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-2 times daily, between meals\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Support for occasional mental and physical stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRhodiola rosea, a Siberian plant also known as Golden root, has been used traditionally for hundreds of years to help lessen mental and physical stress and to promote endurance.1, 2 Animal studies indicate that the extract also appears to maintain healthy adrenal catecholamine activity during stress and provide cardioprotection by moderating stress-induced catecholamine release in the myocardium.3 Furthermore, Rhodiola rosea has demonstrated the potential to support healthy glucose metabolism.4 Rhodiola may be contraindicated for individuals taking adrenergic-blocking and anti-arrhythmic medications.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Spasov AA, et al. *Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e2. De Bock K, et al. *Int J Sport Nutr Exerc Metab.* 2004 Jun;14(3):298-307.\u003cbr\u003e3. Maslova LV, et al. *Eksp Klin Farmakol.*1994 Nov-Dec;57(6):61-3.\u003cbr\u003e4. Li HB, et al. *Eur J Pharmacol.* 2008 Jul 7;588(2-3):165-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Rhodiola rosea is derived from the root and standardized to contain 3% total rosavins and 1% salidroside\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275347316932,"sku":null,"price":23.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/ed66f4c686336a108e96488b1695e6333191d62d8b82e0294904e8bb58624abc.avif?v=1782146615"},{"product_id":"rhodiola-rosea-180ct","title":"Rhodiola Rosea 180ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Helps moderate occasional mental and physical stress\u003cbr\u003e* Supports cardiovascular health\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003cbr\u003e* Standardized to contain 3% total rosavins and 1% salidroside\u003cbr\u003e* Made with high-quality ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-2 times daily, between meals\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Support for occasional mental and physical stress\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eRhodiola rosea, a Siberian plant also known as Golden root, has been used traditionally for hundreds of years to help lessen mental and physical stress and to promote endurance.1, 2 Animal studies indicate that the extract also appears to maintain healthy adrenal catecholamine activity during stress and provide cardioprotection by moderating stress-induced catecholamine release in the myocardium.3 Furthermore, Rhodiola rosea has demonstrated the potential to support healthy glucose metabolism.4 Rhodiola may be contraindicated for individuals taking adrenergic-blocking and anti-arrhythmic medications.\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Spasov AA, et al. *Phytomedicine.* 2000 Apr;7(2):85-9.\u003cbr\u003e2. De Bock K, et al. *Int J Sport Nutr Exerc Metab.* 2004 Jun;14(3):298-307.\u003cbr\u003e3. Maslova LV, et al. *Eksp Klin Farmakol.*1994 Nov-Dec;57(6):61-3.\u003cbr\u003e4. Li HB, et al. *Eur J Pharmacol.* 2008 Jul 7;588(2-3):165-9.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Rhodiola rosea is derived from the root and standardized to contain 3% total rosavins and 1% salidroside\u003cbr\u003e* Hypoallergenic plant fiber is derived from pine cellulose\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275347382468,"sku":null,"price":42.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/ed66f4c686336a108e96488b1695e6333191d62d8b82e0294904e8bb58624abc_1.avif?v=1782146674"},{"product_id":"same-s-adenosylmethionine-60ct","title":"SAMe (S-Adenosylmethionine) 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports methylation and glutathione production\u003cbr\u003e* Promotes cognitive health and positive mood\u003cbr\u003e* Enhances joint comfort, flexibility and integrity\u003cbr\u003e* Provides support for neurotransmitter synthesis, cell membrane fluidity and healthy cell growth\u003cbr\u003e* Provides enhanced stability SAMe\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Cognitive and positive mood support\u003cbr\u003e* Joint health and comfort support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eSAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and\/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins.1 Methyl groups act as a signal throughout the body regulating genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism.2 SAMe also functions as a precursor molecule for glutathione and promotes polyamine synthesis to promote healthy cellular function. The polyamines spermidine and spermine maintain healthy cell growth and cytokine balance. Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells.3 SAMe also supports cognitive function and mood. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood.4 While the exact mechanism for this benefit has not been determined, it is believed that SAMe supports neurotransmitter monoamine synthesis and function, including dopamine and serotonin, through SAMe-dependent methylation reactions.5 By supporting methylation, SAMe promotesphosphatidylcholine production and cellular membrane integrity and fluidity.6 Multiple clinical trials indicate that SAMe supports joint comfort and flexibility.7 In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function.8 In another 16-week, randomized, double-blind, placebo-controlled trial involving 56 subjects, SAMe offered statistically significant support for joint comfort. It is believed that SAMe enhances joint comfort and function by supporting proteoglycan synthesis, and by helping to stabilize and protect the proteoglycans.9\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Pfalzer AC, et. al. *Physiol Genomics.* 2014 Sep 1;46(17):617-23.\u003cbr\u003e2. Luo H, et. al. *Plos Biology* March 11 2019\u003cbr\u003e3. Loguercio C, et. al. *Alcohol Alcohol.* 1994 Sep;29(5):597-604.\u003cbr\u003e4. Bressa GM. *Acta Neurol Scand Sup.* 1994;154:7-14.\u003cbr\u003e5. Levkovitz Y, et. al. *J Affect Disord.* 2012 Feb;136(3):1174-8.\u003cbr\u003e6. Boger R, et. al. *Circ Res.* 2000;87-99-015\u003cbr\u003e7. Najm W, et. al. *BMC Musculoskelet Disord.* 2004; 5: 6.\u003cbr\u003e8. Soeken KL, et. al. *J Fam Pract.* 2002 May;51(5):425-30.\u003cbr\u003e9. Najm WI, et. al. *BMC Musculoskelet Disord.* 2004 Feb 26;5:6.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eSAMe is derived from fermentation\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275347480772,"sku":null,"price":84.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/48fb4405852461a19b3eeebd5d190453d37ae51c57cbf474fbd32eef87d9c4f4.avif?v=1782146781"},{"product_id":"seroplus-120ct","title":"SeroPlus 120ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e* Supports healthy serotonin productio\u003cbr\u003e* Promotes relaxation and helps moderate occasional stress\u003cbr\u003e* Made with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules, 1-2 times daily, between meals.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003e* Ages 18 and up\u003cbr\u003e* Positive mood and relaxation support\u003cbr\u003e* Healthy eating behavior support\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003eSeroPlus promotes serotonin synthesis to support relaxation, moderate occasional stress and maintain healthy eating behavior. This formula provides the serotonin precursor, 5-HTP, and inositol, which supports healthy sensitization of serotonin receptors.2 Taurine also supports healthy serotonin activity, potentially by maintaining healthy reuptake.3 Niacinamide and zinc enhance 5-HTP availability.4, 5 This formula includes the cofactors magnesium, vitamin C, vitamin B6 and Metafolin® L-5-MTHF to support serotonin production and positive mood.6, 7, 8 In a randomized, controlled trial involving elderly individuals, magnesium offered statistically significant support for positive mood.9 In another double-blind, randomized and placebo-controlled trial involving young women, zinc supplementation offered statistically significant support for positive mood.10\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Emanuele E, et al. *Neuro Endocrinol Lett*. 2010;31(5):663-6.\u003cbr\u003e2. Gianfranco C, et al. *Hum Psychopharmacol*. 2011 Oct;26(7):526-30\u003cbr\u003e3. Becquet D, et al. *Neurochem Int*. 1993 Sep;23(3):269-83.\u003cbr\u003e4. Prousky JE. *J of Orthomolecular Medicine*. 2005. 20(3); 167-178.\u003cbr\u003e5. Nowak G, et al. *Pol J Pharmacol*. 2003 Nov-Dec;55(6):1143-7.\u003cbr\u003e6. de Oliveira IJ, et al. *Pak J Biol Sci*. 2015 Jan;18(1):11-8.\u003cbr\u003e7. Doll H, et al. *J R Coll Gen Pract*. 1989 Sep;39(326):364-8.\u003cbr\u003e8. Papakostas GI, et. al. *J Clin Psychiatry*. 2014 Aug;75(8):855-63.\u003cbr\u003e9. Jacka FN, et al. *Aust N Z J Psychiatry*. 2009 Jan;43(1):45-52.\u003cbr\u003e10. Sawada T, et al. *Eur J Clin Nutr*. 2010 Mar;64(3):331-3.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.PHENYLKETONURICS: CONTAINS PHENYLALANINE\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e* Ascorbic acid is derived from corn dextrose fermentation\u003cbr\u003e* Niacinamide, pyridoxal 5' phosphate, folate (Metafolin® , L-5-MTHF) and taurine are synthetic\u003cbr\u003e* Magnesium and zinc are derived from the lime of rock\u003cbr\u003e* 5-Hydroxytryptophan is derived from *Griffonia simplicifolia* seeds\u003cbr\u003e* Myo-inositol is derived from rice bran\"]\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275348070596,"sku":null,"price":58.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/d7a4da84a946ef5b67d25ca1869298c5cd828d13dc40391f549ad93cba5a979f.avif?v=1782147618"}],"url":"https:\/\/valvistapharmacy.com\/collections\/mental-health-stress-support.oembed","provider":"Val Vista Pharmacy","version":"1.0","type":"link"}