{"product_id":"folate-5-000-60ct","title":"Folate 5,000 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003e\nProvides the active form of folate, directly bioavailable without metabolic activation\u003cbr\u003e\nProvides cardiovascular, cellular and neural protection‡\u003cbr\u003e\n5, 000 mcg of activated folate per capsule\u003cbr\u003e\nContains Metafolin® , the universally metabolized and biologically active form of folate\u003cbr\u003e\nMade with high-quality, vegan ingredients backed by verifiable science\u003c\/p\u003e\n\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003e\nAs a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eIndications:\u003cbr\u003e\nAges 18 and up\u003cbr\u003e\nCardiovascular, cellular and neuronal support‡\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003e\nFolate 5, 000 provides 5, 000 mcg of folate as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate. ^1, 2^ Genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent.^3^ Through bypassing several enzymatic activation steps catalyzed by DHFR (dihydrofolate reductase) and MTHFR (methylenetetrahydrofolate reductase), 5-MTHF is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations in these enzymes.^4^ At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues.^5, 6^ In addition, folate promotes the production of healthy DNA.^7‡^\u003c\/p\u003e\n\n\u003cp\u003eReferences:\u003cbr\u003e\n1. Prinz-Langenohl R, et al. *Br J Pharmacol.* 2009 Dec; 158(8): 2014â€\"2021.\u003cbr\u003e\n2. Lamers Y\u003c\/p\u003e\n\n\u003cp\u003eWarning:\u003cbr\u003e\net al. *Am J Clin Nutr.* 2006 Jul;84(1):156-61.\u003cbr\u003e\n3. Yang Q\u003c\/p\u003e\n\n\u003cp\u003eStorage:\u003cbr\u003e\net al. *Am J Clin Nutr.* 2012;95(5):1245-1253.\u003cbr\u003e\n4. Seremak-Mrozikiewicz A. *Ginekol Pol.* 2013 Jul;84(7):641-6.\u003cbr\u003e\n5. Terry MB\u003c\/p\u003e\n\n\u003cp\u003eSource:\u003cbr\u003e\net al. *Epigenetics.* 2011. 6(7); 828-37.\u003cbr\u003e\n6. Stanhewicz AE\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275326640324,"sku":null,"price":73.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/4421b8549a0ecf5139822b91a6a0f85299ac2e1f437934bd3e1fffa01d82fb2f.avif?v=1781968864","url":"https:\/\/valvistapharmacy.com\/products\/folate-5-000-60ct","provider":"Val Vista Pharmacy","version":"1.0","type":"link"}