{"product_id":"phyto-4-60ct","title":"Phyto-4 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003ePromotes joint health \u0026amp; comfort\u003cbr\u003eSupports healthy immune response\u003cbr\u003eProvides support for connective tissue structural composition\u003cbr\u003eIncludes clinically researched botanicals\u003cbr\u003eMade with high-quality vegan ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 2 capsules daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eJoint health and comfort\u003cbr\u003eImmune function and tissue health\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePerluxan® is a clinically studied extract of hops specifically developed to promote joint health. In a randomized, double-blind, placebo-controlled trial of 36 subjects, the benefits of Perluxan® on joint comfort reached statistical significance within two hours of the first dose and were sustained over the 14-day period. Perluxan® is free of sleep-inducing and phytoestrogenic compounds typically associated with hops extracts.1 The alpha and iso-alpha acids in Perluxan® maintain healthy NF-kappa B-associated expression of COX-2 and cytokines such as IL-6 and TNFα in connective tissue.2 Curcumin complements Perluxan® through its extensively characterized effects on cytokine-mediated signal transduction, matrix metalloproteinase (MMP) expression and multiple components of the arachidonic acid cascade.3 Curcumin C3 Complex® is the subject of extensive ongoing clinical investigations at numerous hospitals and universities.4 Ginger promotes joint health through maintaining healthy cytokine signaling in cartilage and the synovium.5 5LOXIN® *Boswellia serrata* extract provides the highly bioactive triterpenoid AKBA, which supports connective tissue structural composition and comfort through supporting healthy immune responses, 5-lipoxygenase activity and synovial matrix metalloproteinase 3 (MMP-3) levels.6, 7 In a 3-month double-blind, placebo-controlled study of 75 subjects, significant functional support and comfort scores were evident as early as day 7.8\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. R Jager, et al. *Pharmachem Laboratories,* Kearny, NJ.\u003cbr\u003e2. an Cleemput M, et al.*Mol Nutr Food Res.* 2009 Sep;53(9):1143-55.\u003cbr\u003e3. Panahi Y, et al. *Biomed Pharmacother.* 2016 Aug;82:578-82.\u003cbr\u003e4. Chandran B, et al.*Phytother Res.* 2012 Nov;26(11):1719-25.\u003cbr\u003e5. Altman RD, et al. *Arthritis Rheum.* 2001 Nov;44(11):2531-8.\u003cbr\u003e6. Roy S, et al. *DNA Cell Biol.* 2005 Apr;24(4):244-55.\u003cbr\u003e7. Krishanu S, et al. *Int J Med Sci.*2010; 7(6): 366?77.\u003cbr\u003e8. Krishanu S, et al. *Arthritis Res Ther.*2008; 10(4): R85.\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eNot to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eStore in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003eProprietary hops extract is derived from *Humulus lupulus* cone\u003cbr\u003eCurcumin C3 Complex® turmeric extract is derived from *Curcuma longa* root and standardized to contain 95% curcuminoids\u003cbr\u003eGinger extract is derived from *Zingiber officinale* root and standardized to contain 5% gingerols\u003cbr\u003e5-LOXIN® *Boswellia serrata* extract is derived from the gum resin and standardized to contain 30% 3-acetyl-11-Keto-beta-boswellic acid (AKBA)\u003cbr\u003eAscorbyl palmitate is derived from corn dextrose fermentation and palm oil\u003cbr\u003eMaltodextrin is derived from corn\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275343515844,"sku":null,"price":49.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e43781078afc788a65e2ff00f0a9065e1d88cebf5dc1ca894b2b5bf6d01955c3.avif?v=1782137225","url":"https:\/\/valvistapharmacy.com\/products\/phyto-4-60ct","provider":"Val Vista Pharmacy","version":"1.0","type":"link"}