{"product_id":"puregenomics-multivitamin-60ct","title":"PureGenomics® Multivitamin 60ct","description":"\u003cp\u003eBenefits \u0026amp; Features:\u003cbr\u003eSupports optimal nutrient intakes for individuals with common genetic variations\u003cbr\u003eSupports methylation, which maintains healthy neurotransmission, DNA synthesis and gene regulation2\u003cbr\u003ePromotes macular and retinal health\u003cbr\u003eSupports overall wellness\u003cbr\u003eProvides vitamins A, B, C, D, E and K in highly bioavailable forms\u003cbr\u003eIncludes Metafolin®, the naturally occurring, universally metabolized form of folate\u003cbr\u003eOffers vitamin B12 as a unique blend of the two active isomers (adenosylcobalamin and hydroxycobalamin)\u003cbr\u003ePart of the PureGenomics® product line\u003cbr\u003eConvenient one-capsule-per-day dosing\u003cbr\u003eMade with high-quality vegetarian ingredients backed by verifiable science\u003c\/p\u003e\n\u003cp\u003eDirections \/ Usage:\u003cbr\u003eAs a dietary supplement, take 1 capsule daily, with a meal.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eAges 18 and up\u003cbr\u003eDaily wellness\u003cbr\u003eFormula targeting common genetic polymorphisms\u003c\/p\u003e\n\u003cp\u003eScience \u0026amp; Research:\u003cbr\u003ePureGenomics® Multivitamin is a once-daily multivitamin\/mineral formula designed to address the nutrient requirements associated with common genetic variations. Activated B vitamins, including pyridoxal-5- phosphate, riboflavin-5-phosphate and the enhanced-retention thiamin derivative, benfotiamine. Methylation plays many roles including neurotransmission, DNA synthesis and gene regulation.1, 2 Riboflavin is an essential cofactor for MTHFR, a genetically polymorphic enzyme that supports the methylation of homocysteine and other substrates as part of the methylation pathway. Individuals with the rs1801133 TT variant exhibited enhanced cardiovascular benefits from supplemental riboflavin in multiple clinical trials.3, 4 Since the MTHFR T allele also reduces the activation of folate to L-5-methyltetrahydrofolate (L-5-MTHF), this formula provides 800 mcg of Metafolin® (L-5-MTHF), a naturally occurring, universally metabolized form of folate that does not require MTHFR for activation.5 PureGenomics® Multivitamin provides vitamin B12 as a blend of adenosylcobalamin and hydroxycobalamin to support both mitochondrial function and methylation.1, 6 Choline is a critical methyl donor that plays important roles in neuronal maintenance and cognitive function.1 Certain genetic variations in MTHFR and PEMT, enzymes that play critical roles in methylation and choline synthesis, respectively, have been associated with increased dietary choline needs.7-9 Since many genetic variations influence vitamin D metabolism, transport and receptor function, PureGenomics® Multivitamin provides 25 mcg (1, 000 IU) vitamin D to support optimal dietary intakes.^10^ Pre-formed vitamin A is also included to allow efficient assimilation of retinol in individuals with BCMO1 polymorphisms, which may reduce the conversion of beta-carotene to active vitamin A.11 Lutein and zeaxanthin are included to support macular and retinal health.12\u003c\/p\u003e\n\u003cp\u003eReferences:\u003cbr\u003e1. Glier MB, et al. *Mol Nutr Food Res.* 2014;58(1):172-82.\u003cbr\u003e2. Gropper SS, Smith JL, Groff JL. *Advanced Nutrition and Human Metabolism.* 5th ed. Belmont, CA: Wadsworth; 2009.\u003cbr\u003e3. McNulty H, et al. *Mol Aspects Med.* 2017;53:2-9.\u003cbr\u003e4. Horigan G, et al. *J Hypertens.* 2010;28(3):478-86.\u003cbr\u003e5. Prinz-Langenohl R, et al. *Br J Pharmacol.* 2009; 158(8): 2014â€\"21.\u003cbr\u003e6. Kok\u003c\/p\u003e\n\u003cp\u003eWarning:\u003cbr\u003eD.E.G.\u003c\/p\u003e\n\u003cp\u003eStorage:\u003cbr\u003eet al. *Clin Epigenet.* 2015;7\u003c\/p\u003e\n\u003cp\u003eSource:\u003cbr\u003e121.\u003cbr\u003e7. Zeisel SH et al. *J Nutr.* 2011;141(3):531-4.\u003cbr\u003e8. Ivanov A\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":46275343483076,"sku":null,"price":46.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0734\/7168\/8900\/files\/e4271f60b91732d513095fac816634710fea92cab7baa9d1679fa7650bdbe41b.avif?v=1782137166","url":"https:\/\/valvistapharmacy.com\/products\/puregenomics-multivitamin-60ct","provider":"Val Vista Pharmacy","version":"1.0","type":"link"}