Benefits & Features:
Provides preformed vitamin A, which bypasses genetic variations that limit conversion of beta-carotene
Supports optical lens health and macular pigment density
Provides antioxidant defenses to protect retinal health
Part of the PureGenomics® product line
Made with high-quality ingredients backed by verifiable science
Directions / Usage:
As a dietary supplement, take 1 capsule daily, with a meal.
Indications:
Ages 18 and up
Eye health
Immune function support
Science & Research:
The ability to convert provitamin A carotenoids, like beta carotene, into active vitamin A varies from one person to the next, owing to genetic variations that can limit enzyme activity. Single nucleotide polymorphisms (SNPs) in the gene encoding the enzyme BCMO1 (β-Carotene 15, 15'-monooxygenase 1) can decrease the conversion efficacy of carotenoids into retinal, the immediate precursor of vitamin A, by up to 69%.1 These common variations can be bypassed with dietary retinol (vitamin A).2 Since variations in the BCMO1 gene have also been associated with macular pigment density, this formula includes a blend of lutein, zeaxanthin and astaxanthin to promote macular health.3 Lutein and zeaxanthin are the two carotenoids found in macular pigment; as such, they act to support the integrity and density of the pigment, as well as optical lens health.4 Astaxanthin offers support for antioxidant defenses to protect retinal health.5
References:
1. Lietz G, et al. *J Nutr.*2012 Jan;142(1):161S-5S.
2. Leung WC, et al.*FASEB J.*2009 Apr;23(4):1041-53.
3. Feigl B, et al.*PLoS One.* 2014 Feb 19;9(2):e89069.
4. Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew EY, Clemons TE, et al. *JAMA Ophthalmol.* 2014 Feb;132(2):142-9.
5. Piermarocchi S, et al. *Eur J Ophthalmol.* 2012 Mar-Apr;22(2):216-25.
Warning:
Vitamin A at levels above 3, 000 mcg (10, 000 IU) can lead to adverse side effects, including birth defects. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Storage:
Store in a cool, dry place.
Source:
Vitamin A and zeaxanthin are synthetic
Lutein is derived from marigold flower extract
Astaxanthin is derived from *Haematococcus pluvialis* algae extract
Red beet powder is derived from *Beta vulgaris* root
Hypoallergenic plant fiber is derived from pine cellulose
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