Optimal D3 5,000 IU with K2 pairs high-potency cholecalciferol with 90 mcg of menaquinone-7 (MK-7), the most bioavailable form of vitamin K2, to support bone strength, cardiovascular health, and proper calcium utilization from the same daily capsule.*
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We always prefer D3 paired with K2 because vitamin K2 (as MK-7) directs calcium to the bones where it belongs, rather than allowing it to deposit in arterial walls. This combination reflects best evidence for patients looking to optimize both bone density and cardiovascular health simultaneously.
"We always recommend D3 paired with K2. Vitamin K2 acts as the traffic director — it tells calcium to go to your bones, not your arteries. Taking D3 alone without K2 is only half the equation for patients focused on bone density and heart health." – Staff Pharmacist
Serving Size: 1 Capsule | Servings Per Container: 60 or 120
Capsule (hypromellose and water), microcrystalline cellulose, ascorbyl palmitate, and silica.
Take one capsule daily, preferably at mealtime, or as directed by your healthcare professional. Both vitamin D and vitamin K2 are fat-soluble, so taking this supplement alongside a meal that contains some dietary fat supports absorption of both nutrients.
5,000 IU is a commonly used dose for adults addressing a measured vitamin D deficiency or maintaining levels in an optimal range. The right dose for you depends on your current serum 25-hydroxyvitamin D levels, which your provider can assess through a standard blood test. If you haven’t been tested recently, it’s worth asking. Our pharmacists can also help you think through the results at (480) 887-0244.
Consult your healthcare professional before use. This product contains vitamin K2, which can interact with blood thinners, including warfarin. If you’re taking any anticoagulant medication, please speak with your prescriber before starting. Individuals taking other medications should also discuss potential interactions with their healthcare professional. Do not use if the tamper seal is damaged.
Optimal D3 5,000 IU with K2 supports two of the most clinically important nutritional priorities for long-term health: vitamin D status and calcium metabolism.
Vitamin D3 supports calcium absorption, and vitamin K2 as MK-7 activates osteocalcin, the protein that binds calcium into the bone mineral matrix. Research has shown MK-7 at 45–90 mcg per day increases osteocalcin carboxylation and improves the ratio of carboxylated to uncarboxylated osteocalcin, a recognized marker of bone health. A three-year study of postmenopausal women found low-dose MK-7 supplementation helped decrease bone loss compared to placebo. Adequate vitamin D throughout life, as part of a well-balanced diet, may also reduce the risk of osteoporosis.*
Vitamin K2 activates matrix GLA protein (MGP), the body’s primary inhibitor of arterial calcification. Research has shown that higher long-term intake of long-chain menaquinones is inversely associated with coronary calcification, and that supplementation with vitamin K reduces arterial calcium deposits. At a 5,000 IU D3 dose, where calcium absorption is meaningfully supported, the presence of K2 helps ensure that absorbed calcium is directed toward skeletal tissue rather than soft tissue.*
The K2-D3 5000 formulation carries 90 mcg of MK-7, which is at the higher end of the range used in bone health research (typically 45–90 mcg/d). This amount is supported by published studies on osteocalcin carboxylation and bone density in postmenopausal women. It’s worth noting that the XYMOGEN research sheet flags that MK-7 supplements above 50 mcg/d may interfere with oral anticoagulant treatment for sensitive individuals. If you’re taking a blood thinner, please see the important considerations section above and speak with your provider before starting.*
Beyond bone health, maintaining optimal vitamin D levels supports immune function, cardiovascular health, healthy blood glucose metabolism, neurologic function, and musculoskeletal comfort. Vitamin D3 (cholecalciferol) is approximately 87% more potent than D2 at raising and maintaining serum vitamin D concentrations, which is why D3 is the preferred supplemental form.*
When you buy a supplement from Val Vista Pharmacy, you’re buying from a licensed, practicing pharmacy, not a marketplace, not a fulfillment warehouse. That distinction matters for a few reasons.
Every supplement we carry has been evaluated by our pharmacists for ingredient quality, formulation rationale, and manufacturer standards. Optimal D3 5,000 IU with K2 uses Vitamk7â„¢, a naturally derived and solvent-free MK-7 produced through a patent-granted biofermentation process. The formula meets or exceeds current good manufacturing practice (cGMP) quality standards.
Most supplement retailers can’t answer a clinical question about their products. We can. If you want to know whether 5,000 IU is the right dose for your labs, how this formula compares to our 10,000 IU option, or how it fits alongside your other medications or compounded prescriptions, call us at (480) 887-0244 and we’ll give you a straight answer.
All supplement orders over $149 ship free.
Val Vista Pharmacy is a family-owned, independent pharmacy in Gilbert, AZ. We built our practice around the idea that people deserve more than a transaction when it comes to their health. Whether you’re filling a compounded prescription or ordering supplements for the first time, you’ll be treated like a person, not an order number.
If you are ready to work with a personalized medication pharmacy in Gilbert, AZ that puts consistency, communication, and accountability first, we would love to be your partner in care. Let's connect.
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